PDBsum entry 2xmy

Transferase

PDB id: 2xmy

Contents

Protein chain

295 a.a. *

Ligands

CDK

Waters ×255

* Residue conservation analysis

PDB id:

2xmy

Name:

Transferase

Title:

Discovery and characterisation of 2-anilino-4-(thiazol-5-yl) pyrimidine transcriptional cdk inhibitors as anticancer agents

Structure:

Cell division protein kinase 2. Chain: a. Synonym: p33 protein kinase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Resolution:

1.90Å R-factor: 0.192 R-free: 0.271

Authors:

S.Wang,G.Griffiths,C.A.Midgley,A.L.Barnett,M.Cooper,J.Grabarek, L.Ingram,W.Jackson,G.Kontopidis,S.J.Mcclue,C.Mcinnes,J.Mclachlan, C.Meades,M.Mezna,I.Stuart,M.P.Thomas,D.I.Zheleva,D.P.Lane, R.C.Jackson,D.M.Glover,D.G.Blake,P.M.Fischer

Key ref:

S.Wang et al. (2010). Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents. Chem Biol, 17, 1111-1121. PubMed id: 21035734

Date:

29-Jul-10 Release date: 10-Nov-10

Protein chain

P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2 from Homo sapiens

Seq: 298 a.a.

Struc: 295 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.22 - cyclin-dependent kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Chem Biol 17:1111-1121 (2010)

PubMed id: 21035734

Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents.

S.Wang, G.Griffiths, C.A.Midgley, A.L.Barnett, M.Cooper, J.Grabarek, L.Ingram, W.Jackson, G.Kontopidis, S.J.McClue, C.McInnes, J.McLachlan, C.Meades, M.Mezna, I.Stuart, M.P.Thomas, D.I.Zheleva, D.P.Lane, R.C.Jackson, D.M.Glover, D.G.Blake, P.M.Fischer.

ABSTRACT

No abstract given.