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PDBsum entry 2xjz

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protein metals Protein-protein interface(s) links
Oncoprotein PDB id
2xjz

 

 

 

 

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Contents
Protein chains
125 a.a. *
112 a.a. *
29 a.a. *
31 a.a. *
21 a.a. *
26 a.a. *
Metals
_ZN ×20
_CL ×2
Waters ×57
* Residue conservation analysis
PDB id:
2xjz
Name: Oncoprotein
Title: Crystal structure of the lmo2:ldb1-lid complex, c2 crystal form
Structure: Rhombotin-2. Chain: a, b, c, d, e. Fragment: residues 26-156. Synonym: lim domain only protein 2, cysteine-rich protein ttg-2, t- cell translocation protein 2, lmo-2. Engineered: yes. Lim domain-binding protein 1. Chain: i, j, k, l, m. Fragment: residues 334-368.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Resolution:
2.80Å     R-factor:   0.229     R-free:   0.244
Authors: K.El Omari,D.Karia,C.Porcher,E.J.Mancini
Key ref: K.El Omari et al. (2011). Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex. Blood, 117, 2146-2156. PubMed id: 21076045
Date:
06-Jul-10     Release date:   21-Jul-10    
PROCHECK
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 Headers
 References

Protein chains
P25791  (RBTN2_HUMAN) -  Rhombotin-2 from Homo sapiens
Seq:
Struc:
158 a.a.
125 a.a.
Protein chain
P25791  (RBTN2_HUMAN) -  Rhombotin-2 from Homo sapiens
Seq:
Struc:
158 a.a.
112 a.a.*
Protein chains
Q86U70  (LDB1_HUMAN) -  LIM domain-binding protein 1 from Homo sapiens
Seq:
Struc:
411 a.a.
29 a.a.
Protein chain
Q86U70  (LDB1_HUMAN) -  LIM domain-binding protein 1 from Homo sapiens
Seq:
Struc:
411 a.a.
31 a.a.*
Protein chain
Q86U70  (LDB1_HUMAN) -  LIM domain-binding protein 1 from Homo sapiens
Seq:
Struc:
411 a.a.
21 a.a.
Protein chain
Q86U70  (LDB1_HUMAN) -  LIM domain-binding protein 1 from Homo sapiens
Seq:
Struc:
411 a.a.
26 a.a.
Key:    Secondary structure  CATH domain
* PDB and UniProt seqs differ at 5 residue positions (black crosses)

 

 
Blood 117:2146-2156 (2011)
PubMed id: 21076045  
 
 
Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex.
K.El Omari, S.J.Hoosdally, K.Tuladhar, D.Karia, P.Vyas, R.Patient, C.Porcher, E.J.Mancini.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23303138 J.M.Matthews, K.Lester, S.Joseph, and D.J.Curtis (2012).
LIM-domain-only proteins in cancer.
  Nat Rev Cancer, 13, 111-122.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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