PDBsum entry 2xjy

Oncoprotein

PDB id

2xjy

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Contents

			Protein chains

					131 a.a. *


					35 a.a. *

			Metals

					_ZN ×4

			Waters ×33

* Residue conservation analysis

PDB id:

2xjy

Links

Name:

Oncoprotein

Title:

Crystal structure of the lmo2:ldb1-lid complex, p21 crystal form

Structure:

Rhombotin-2. Chain: a. Fragment: residues 26-156. Synonym: lim domain only protein 2, cysteine-rich protein ttg-2, t- cell translocation protein 2, lmo-2. Engineered: yes. Lim domain-binding protein 1. Chain: b. Fragment: residues 334-368.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Resolution:

2.40Å

R-factor:

0.202

R-free:

0.229

Authors:

K.El Omari,D.Karia,C.Porcher,E.J.Mancini

Key ref:

K.El Omari et al. (2011). Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex. Blood, 117, 2146-2156. PubMed id: 21076045

Date:

06-Jul-10

Release date:

21-Jul-10

PROCHECK

	Headers

	References

Protein chain

P25791 (RBTN2_HUMAN) - Rhombotin-2 from Homo sapiens

Seq: Struc:					158 a.a. 131 a.a.

Protein chain

Q86U70 (LDB1_HUMAN) - LIM domain-binding protein 1 from Homo sapiens

Seq: Struc:					411 a.a. 35 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

	Blood 117:2146-2156 (2011)
PubMed id: 21076045

Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex.
K.El Omari, S.J.Hoosdally, K.Tuladhar, D.Karia, P.Vyas, R.Patient, C.Porcher, E.J.Mancini.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23303138

J.M.Matthews, K.Lester, S.Joseph, and D.J.Curtis (2012).
LIM-domain-only proteins in cancer.

Nat Rev Cancer, 13, 111-122.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.