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PDBsum entry 2xir
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PDB id:
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Transferase
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Title:
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Crystal structure of the vegfr2 kinase domain in complex with pf- 00337210 (n,2-dimethyl-6-(7-(2-morpholinoethoxy)quinolin-4-yloxy) benzofuran-3-carboxamide)
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Structure:
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Vascular endothelial growth factor receptor 2. Chain: a. Fragment: kinase domain, residues 806-939,990-1171. Synonym: vegfr-2, kinase insert domain receptor, protein-tyrosine kinase receptor flk-1, fetal liver kinase 1, flk-1, cd309. Engineered: yes. Mutation: yes
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Source:
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Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
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Resolution:
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1.50Å
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R-factor:
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0.219
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R-free:
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0.238
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Authors:
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M.Mctigue,J.Wickersham,C.Pinko,Y.Hong,T.Marrone
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Key ref:
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M.Mctigue
et al.
Discovery of the selective vegfr inhibitor pf- 003372.
To be published,
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Date:
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30-Jun-10
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Release date:
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13-Apr-11
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PROCHECK
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Headers
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References
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P35968
(VGFR2_HUMAN) -
Vascular endothelial growth factor receptor 2 from Homo sapiens
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Seq:
Struc:
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1356 a.a.
296 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
