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PDBsum entry 2xew
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Contents |
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* Residue conservation analysis
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PDB id:
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Cell cycle
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Title:
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Crystal structure of k11-linked diubiquitin
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Structure:
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Ubiquitin. Chain: a, b, c, d, e, f, g, h, i, j, k, l. Engineered: yes. Other_details: ubiquitin polymer linked through lys11 in an isopeptide linkage
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.20Å
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R-factor:
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0.207
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R-free:
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0.252
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Authors:
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A.Bremm,S.M.V.Freund,D.Komander
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Key ref:
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A.Bremm
et al.
(2010).
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.
Nat Struct Biol,
17,
939-947.
PubMed id:
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Date:
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18-May-10
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Release date:
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14-Jul-10
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PROCHECK
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Headers
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References
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P0CG48
(UBC_HUMAN) -
Polyubiquitin-C from Homo sapiens
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Seq:
Struc:
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685 a.a.
76 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Nat Struct Biol
17:939-947
(2010)
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PubMed id:
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Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.
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A.Bremm,
S.M.Freund,
D.Komander.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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J.D.Licchesi,
J.Mieszczanek,
T.E.Mevissen,
T.J.Rutherford,
M.Akutsu,
S.Virdee,
F.El Oualid,
J.W.Chin,
H.Ovaa,
M.Bienz,
and
D.Komander
(2012).
An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.
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Nat Struct Mol Biol,
19,
62-71.
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PDB code:
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A.Hay-Koren,
M.Caspi,
A.Zilberberg,
and
R.Rosin-Arbesfeld
(2011).
The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin.
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Mol Biol Cell,
22,
399-411.
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C.Behrends,
and
J.W.Harper
(2011).
Constructing and decoding unconventional ubiquitin chains.
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Nat Struct Mol Biol,
18,
520-528.
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E.W.Harhaj,
and
V.M.Dixit
(2011).
Deubiquitinases in the regulation of NF-κB signaling.
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Cell Res,
21,
22-39.
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J.R.McLean,
D.Chaix,
M.D.Ohi,
and
K.L.Gould
(2011).
State of the APC/C: organization, function, and structure.
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Crit Rev Biochem Mol Biol,
46,
118-136.
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K.E.Wickliffe,
S.Lorenz,
D.E.Wemmer,
J.Kuriyan,
and
M.Rape
(2011).
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2.
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Cell,
144,
769-781.
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M.Akutsu,
Y.Ye,
S.Virdee,
J.W.Chin,
and
D.Komander
(2011).
Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
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Proc Natl Acad Sci U S A,
108,
2228-2233.
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PDB codes:
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B.A.Malynn,
and
A.Ma
(2010).
Ubiquitin makes its mark on immune regulation.
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Immunity,
33,
843-852.
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F.El Oualid,
R.Merkx,
R.Ekkebus,
D.S.Hameed,
J.J.Smit,
A.de Jong,
H.Hilkmann,
T.K.Sixma,
and
H.Ovaa
(2010).
Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin.
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Angew Chem Int Ed Engl,
49,
10149-10153.
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F.Ikeda,
N.Crosetto,
and
I.Dikic
(2010).
What determines the specificity and outcomes of ubiquitin signaling?
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Cell,
143,
677-681.
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J.N.Dynek,
T.Goncharov,
E.C.Dueber,
A.V.Fedorova,
A.Izrael-Tomasevic,
L.Phu,
E.Helgason,
W.J.Fairbrother,
K.Deshayes,
D.S.Kirkpatrick,
and
D.Vucic
(2010).
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.
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EMBO J,
29,
4198-4209.
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S.Virdee,
Y.Ye,
D.P.Nguyen,
D.Komander,
and
J.W.Chin
(2010).
Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase.
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Nat Chem Biol,
6,
750-757.
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PDB code:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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Links
