PDBsum entry 2xeu

Transcription

PDB id

2xeu

Loading ...

Contents

			Protein chain

					64 a.a. *

			Ligands

					GLC-FRU


					SO4 ×2

			Metals

					_ZN ×2

			Waters ×54

* Residue conservation analysis

PDB id:

2xeu

Links

Name:

Transcription

Title:

Ring domain

Structure:

Ring finger protein 4. Chain: a. Fragment: ring domain, residues 130-190. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.50Å

R-factor:

0.170

R-free:

0.197

Authors:

A.Plechanovova,S.A.Mcmahon,K.A.Johnson,I.Navratilova,J.H.Naismith, R.T.Hay

Key ref:

A.Plechanovová et al. (2011). Mechanism of ubiquitylation by dimeric RING ligase RNF4. Nat Struct Biol, 18, 1052-1059. PubMed id: 21857666

Date:

18-May-10

Release date:

28-Jul-10

PROCHECK

	Headers

	References

Protein chain

P78317 (RNF4_HUMAN) - E3 ubiquitin-protein ligase RNF4 from Homo sapiens

Seq: Struc:					190 a.a. 64 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 3 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine

	Nat Struct Biol 18:1052-1059 (2011)
PubMed id: 21857666

Mechanism of ubiquitylation by dimeric RING ligase RNF4.
A.Plechanovová, E.G.Jaffray, S.A.McMahon, K.A.Johnson, I.Navrátilová, J.H.Naismith, R.T.Hay.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22902369

H.Dou, L.Buetow, G.J.Sibbet, K.Cameron, and D.T.Huang (2012).
BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.

Nat Struct Mol Biol, 19, 876-883.

PDB code:

4auq

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.