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PDBsum entry 2xae
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PDB id:
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Cell cycle
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Title:
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Crystal structure of human kinesin eg5 in complex with (r)-2-amino-3- ((s)-2-methyl-1,1-diphenylbutylthio)propanoic acid
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Structure:
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Kinesin-like protein kif11. Chain: a, b, c. Fragment: motor domain, residues 1-368. Synonym: eg5, kinesin-related motor protein eg5, kinesin-like spindle protein hksp, thyroid receptor-interacting protein 5, tr-interacting protein 5, trip-5, kinesin-like protein 1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss
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Resolution:
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2.60Å
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R-factor:
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0.185
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R-free:
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0.257
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Authors:
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H.Y.K.Kaan,J.Weiss,D.Menger,V.Ulaganathan,K.Tkocz,C.Laggner, F.Popowycz,B.Joseph,F.Kozielski
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Key ref:
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H.Y.Kaan
et al.
(2011).
Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.
J Med Chem,
54,
1576-1586.
PubMed id:
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Date:
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31-Mar-10
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Release date:
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30-Mar-11
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PROCHECK
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Headers
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References
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P52732
(KIF11_HUMAN) -
Kinesin-like protein KIF11 from Homo sapiens
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Seq:
Struc:
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1056 a.a.
328 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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J Med Chem
54:1576-1586
(2011)
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PubMed id:
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Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.
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H.Y.Kaan,
J.Weiss,
D.Menger,
V.Ulaganathan,
K.Tkocz,
C.Laggner,
F.Popowycz,
B.Joseph,
F.Kozielski.
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ABSTRACT
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