|
|
||
|
|
|
|
|
UniProt functional annotation for P49765 | ||
|
|
|
|
|
|
||
| UniProt code: P49765. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. |
|
||
| Subunit: | |
Homodimer; disulfide-linked. Can also form heterodimer with VEGF. {ECO:0000269|PubMed:16616187}. |
| Subcellular location: | |
Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin. |
| Tissue specificity: | |
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. |
| Ptm: | |
VEGF-B186 is O-glycosylated. {ECO:0000250}. |
| Similarity: | |
Belongs to the PDGF/VEGF growth factor family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.