UniProt functional annotation for Q10714

UniProt code: Q10714.

Organism: Drosophila melanogaster (Fruit fly).
Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
 
Function: May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.
 
Catalytic activity: Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
Cofactor: Binds 1 zinc ion per subunit.
Enzyme regulation: Inhibited by captopril and, to a lesser extent, by lisinopril, trandolaprilat, fosinoprilat and enalaprilat.
Biophysicochemical properties: Kinetic parameters: KM=33.5 uM for angiotensin I; KM=53.4 uM for N-acetyl-Ser-Asp-Lys-Pro; KM=2.59 mM for Hip-His-Leu; KM=10.26 mM for Hip-His-Leu-NH(2); KM=372 uM for (Leu5)enkephalin; KM=1.88 mM for (Leu5)enkephalinamide;
Subcellular location: Secreted, extracellular space.
Tissue specificity: Expressed in vesicular structures in spermatocytes and early spermatids (at protein level).
Developmental stage: Expressed in the amnioserosa during germ band elongation, shortening and heart morphogenesis. Expressed in midgut throughout embryogenesis.
Ptm: Glycosylated.
Disruption phenotype: Male flies are sterile.
Similarity: Belongs to the peptidase M2 family.

Annotations taken from UniProtKB at the EBI.