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PDBsum entry 2x5h
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Viral protein
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PDB id
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2x5h
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References listed in PDB file
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Key reference
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Title
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The scottish structural proteomics facility: targets, Methods and outputs.
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Authors
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M.Oke,
L.G.Carter,
K.A.Johnson,
H.Liu,
S.A.Mcmahon,
X.Yan,
M.Kerou,
N.D.Weikart,
N.Kadi,
M.A.Sheikh,
S.Schmelz,
M.Dorward,
M.Zawadzki,
C.Cozens,
H.Falconer,
H.Powers,
I.M.Overton,
C.A.Van niekerk,
X.Peng,
P.Patel,
R.A.Garrett,
D.Prangishvili,
C.H.Botting,
P.J.Coote,
D.T.Dryden,
G.J.Barton,
U.Schwarz-Linek,
G.L.Challis,
G.L.Taylor,
M.F.White,
J.H.Naismith.
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Ref.
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J Struct Funct Genomics, 2010,
11,
167-180.
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PubMed id
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Abstract
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The Scottish Structural Proteomics Facility was funded to develop a laboratory
scale approach to high throughput structure determination. The effort was
successful in that over 40 structures were determined. These structures and the
methods harnessed to obtain them are reported here. This report reflects on the
value of automation but also on the continued requirement for a high degree of
scientific and technical expertise. The efficiency of the process poses
challenges to the current paradigm of structural analysis and publication. In
the 5 year period we published ten peer-reviewed papers reporting structural
data arising from the pipeline. Nevertheless, the number of structures solved
exceeded our ability to analyse and publish each new finding. By reporting the
experimental details and depositing the structures we hope to maximize the
impact of the project by allowing others to follow up the relevant biology.
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