UniProt functional annotation for O94829



	UniProt functional annotation for O94829

UniProt code: O94829.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. {ECO:0000250, ECO:0000269|PubMed:11447110, ECO:0000269|PubMed:15143176}.

Subunit: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6. {ECO:0000269|PubMed:11447110, ECO:0000269|PubMed:15143176, ECO:0000269|PubMed:20122403, ECO:0000269|PubMed:21139563}.

Subcellular location: Cytoplasm. Nucleus.

Tissue specificity: Expressed in fetal brain, heart, intestine and kidney. {ECO:0000269|PubMed:10745026}.

Similarity: Belongs to the importin beta family. {ECO:0000305}.

Sequence caution: Sequence=BAA34444.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14575.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. {ECO:0000250, ECO:0000269\|PubMed:11447110, ECO:0000269\|PubMed:15143176}.


Subunit:		Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6. {ECO:0000269\|PubMed:11447110, ECO:0000269\|PubMed:15143176, ECO:0000269\|PubMed:20122403, ECO:0000269\|PubMed:21139563}.
Subcellular location:		Cytoplasm. Nucleus.
Tissue specificity:		Expressed in fetal brain, heart, intestine and kidney. {ECO:0000269\|PubMed:10745026}.
Similarity:		Belongs to the importin beta family. {ECO:0000305}.
Sequence caution:		Sequence=BAA34444.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14575.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};