UniProt functional annotation for P26039



	UniProt functional annotation for P26039

UniProt code: P26039.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.

Subunit: Part of a complex composed of THSD1, PTK2/FAK1, TLN1 and VCL (By similarity). Interacts with THSD1; this promotes interaction with PTK2/FAK1 and VCL (By similarity). Interacts with NRAP and LAYN (By similarity). Interacts with SYNM (By similarity). Interacts with ITGB1; the interaction is prevented by competitive binding of ITGB1BP1 (By similarity). Binds with high affinity to VCL and with low affinity to integrins (PubMed:23389036, PubMed:20610383, PubMed:15642262, PubMed:15272303). Interacts with APBB1IP; this inhibits VCL binding (PubMed:23389036). Interacts with PTK2/FAK1 (PubMed:7622520). Interacts with PIP5K1C (PubMed:15623515). Interacts with F-actin (PubMed:20610383). {ECO:0000250|UniProtKB:P54939, ECO:0000250|UniProtKB:Q9Y490, ECO:0000269|PubMed:15272303, ECO:0000269|PubMed:15623515, ECO:0000269|PubMed:15642262, ECO:0000269|PubMed:20610383, ECO:0000269|PubMed:23389036, ECO:0000269|PubMed:7622520}.

Subcellular location: Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000269|PubMed:21768292}. Cell junction, focal adhesion {ECO:0000269|PubMed:21768292}. Note=Colocalizes with LAYN at the membrane ruffles (By similarity). Localized preferentially in focal adhesions than fibrillar adhesions. {ECO:0000250}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.


Subunit:		Part of a complex composed of THSD1, PTK2/FAK1, TLN1 and VCL (By similarity). Interacts with THSD1; this promotes interaction with PTK2/FAK1 and VCL (By similarity). Interacts with NRAP and LAYN (By similarity). Interacts with SYNM (By similarity). Interacts with ITGB1; the interaction is prevented by competitive binding of ITGB1BP1 (By similarity). Binds with high affinity to VCL and with low affinity to integrins (PubMed:23389036, PubMed:20610383, PubMed:15642262, PubMed:15272303). Interacts with APBB1IP; this inhibits VCL binding (PubMed:23389036). Interacts with PTK2/FAK1 (PubMed:7622520). Interacts with PIP5K1C (PubMed:15623515). Interacts with F-actin (PubMed:20610383). {ECO:0000250\|UniProtKB:P54939, ECO:0000250\|UniProtKB:Q9Y490, ECO:0000269\|PubMed:15272303, ECO:0000269\|PubMed:15623515, ECO:0000269\|PubMed:15642262, ECO:0000269\|PubMed:20610383, ECO:0000269\|PubMed:23389036, ECO:0000269\|PubMed:7622520}.
Subcellular location:		Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000269\|PubMed:21768292}. Cell junction, focal adhesion {ECO:0000269\|PubMed:21768292}. Note=Colocalizes with LAYN at the membrane ruffles (By similarity). Localized preferentially in focal adhesions than fibrillar adhesions. {ECO:0000250}.