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PDBsum entry 2wzw

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
2wzw
Jmol
Contents
Protein chains
222 a.a. *
Ligands
FMN ×2
NDP
PO4 ×3
Waters ×373
* Residue conservation analysis
PDB id:
2wzw
Name: Oxidoreductase
Title: Crystal structure of the fmn-dependent nitroreductase nfnb from mycobacterium smegmatis in complex with NADPH
Structure: Nfnb protein. Chain: a, b. Synonym: nitroreductase nfnb. Engineered: yes
Source: Mycobacterium smegmatis. Organism_taxid: 246196. Strain: mc2 155. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.80Å     R-factor:   0.150     R-free:   0.172
Authors: M.Bellinzoni,G.Manina,G.Riccardi,P.M.Alzari
Key ref: G.Manina et al. (2010). Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance. Mol Microbiol, 77, 1172-1185. PubMed id: 20624223
Date:
03-Dec-09     Release date:   14-Jul-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
A0R6D0  (A0R6D0_MYCS2) -  NfnB protein
Seq:
Struc:
234 a.a.
222 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     oxidation-reduction process   1 term 
  Biochemical function     nucleotide binding     2 terms  

 

 
Mol Microbiol 77:1172-1185 (2010)
PubMed id: 20624223  
 
 
Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance.
G.Manina, M.Bellinzoni, M.R.Pasca, J.Neres, A.Milano, A.L.Ribeiro, S.Buroni, H.Skovierová, P.Dianišková, K.Mikušová, J.Marák, V.Makarov, D.Giganti, A.Haouz, A.P.Lucarelli, G.Degiacomi, A.Piazza, L.R.Chiarelli, E.De Rossi, E.Salina, S.T.Cole, P.M.Alzari, G.Riccardi.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21346818 P.K.Crellin, R.Brammananth, and R.L.Coppel (2011).
Decaprenylphosphoryl-β-D-Ribose 2'-Epimerase, the Target of Benzothiazinones and Dinitrobenzamides, Is an Essential Enzyme in Mycobacterium smegmatis.
  PLoS One, 6, e16869.  
21129975 S.Ekins, J.S.Freundlich, I.Choi, M.Sarker, and C.Talcott (2011).
Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery.
  Trends Microbiol, 19, 65-74.  
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