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PDBsum entry 2wpl
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protein ligands Protein-protein interface(s) links
Blood clotting PDB id
2wpl

 

 

 

 

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Contents
Protein chains
59 a.a. *
235 a.a. *
Ligands
DPN-PRO-ARG
Waters ×287
* Residue conservation analysis
PDB id:
2wpl
Name: Blood clotting
Title: Factor ixa superactive triple mutant, edta-soaked
Structure: Coagulation factor ixa light chain. Chain: e. Fragment: egf2 domain, residues 133-191. Synonym: human coagulation factor ixa, christmas factor, plasma thromboplastin component, ptc. Engineered: yes. D-phe-pro-arg-chloromethyl ketone. Chain: l. Engineered: yes.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630.
Resolution:
1.82Å     R-factor:   0.227     R-free:   0.289
Authors: T.Zogg,H.Brandstetter
Key ref: T.Zögg and H.Brandstetter (2009). Structural basis of the cofactor- and substrate-assisted activation of human coagulation factor IXa. Structure, 17, 1669-1678. PubMed id: 20004170
Date:
06-Aug-09     Release date:   22-Dec-09    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00740  (FA9_HUMAN) -  Coagulation factor IX from Homo sapiens
Seq:
Struc: 		461 a.a.
59 a.a.
Protein chain
Pfam   ArchSchema ?
P00740  (FA9_HUMAN) -  Coagulation factor IX from Homo sapiens
Seq:
Struc: 		461 a.a.
235 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains E, S: E.C.3.4.21.22  - coagulation factor IXa.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Hydrolyzes one Arg-|-Ile bond in factor X to form factor Xa.

 

 
Structure 17:1669-1678 (2009)
PubMed id: 20004170  
 
 
Structural basis of the cofactor- and substrate-assisted activation of human coagulation factor IXa.
T.Zögg, H.Brandstetter.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
20809655 A.D.Vogt, A.Bah, and E.Di Cera (2010).
Evidence of the E*-E equilibrium from rapid kinetics of Na+ binding to activated protein C and factor Xa.
  J Phys Chem B, 114, 16125-16130.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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