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PDBsum entry 2wd2

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Lyase PDB id
2wd2
Jmol
Contents
Protein chain
254 a.a.
Ligands
MS5
FMT ×3
Metals
_ZN ×2
Waters ×245

References listed in PDB file
Key reference
Title Chimeric microtubule disruptors.
Authors M.P.Leese, F.L.Jourdan, M.R.Kimberley, G.E.Cozier, N.Thiyagarajan, C.Stengel, S.Regis-Lydi, P.A.Foster, S.P.Newman, K.R.Acharya, E.Ferrandis, A.Purohit, M.J.Reed, B.V.L.Potter.
Ref. Chem.Commun.(Camb.), 2010, 46, 2907-2909. [DOI no: 10.1039/c002558e]
PubMed id 20386818
Abstract
A chimeric approach is used to discover microtubule disruptors with excellent in vitro activity and oral bioavailability; a ligand-protein interaction with carbonic anhydrase that enhances bioavailability is characterised by protein X-ray crystallography. Dosing of a representative chimera in a tumour xenograft model confirms the excellent therapeutic potential of the class.
PROCHECK
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 Headers