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PDBsum entry 2wd1
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References listed in PDB file
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Key reference
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Title
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Discovery of 4-Azaindoles as novel inhibitors of c-Met kinase.
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Authors
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J.Porter,
S.Lumb,
R.J.Franklin,
J.M.Gascon-Simorte,
M.Calmiano,
K.L.Riche,
B.Lallemand,
J.Keyaerts,
H.Edwards,
A.Maloney,
J.Delgado,
L.King,
A.Foley,
F.Lecomte,
J.Reuberson,
C.Meier,
M.Batchelor.
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Ref.
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Bioorg Med Chem Lett, 2009,
19,
2780-2784.
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PubMed id
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Abstract
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A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated
binding mode was confirmed by an X-ray crystal structure and series optimisation
was performed on the basis of this structure. Future directions for series
development are discussed.
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