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PDBsum entry 2wd1
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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Human c-met kinase in complex with azaindole inhibitor
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Structure:
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Hepatocyte growth factor receptor. Chain: a. Fragment: kinase domain, residues 1055-1346. Synonym: scatter factor receptor, hgf/sf receptor, met proto-oncogene tyrosine kinase, c-met. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
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Resolution:
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2.00Å
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R-factor:
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0.212
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R-free:
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0.265
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Authors:
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J.Porter,S.Lumb,R.J.Franklin,J.M.Gascon-Simorte,M.Calmiano,K.Le Riche,B.Lallemand,J.Keyaerts,H.Edwards,A.Maloney,J.Delgado,L.King, A.Foley,F.Lecomte,J.Reuberson,C.Meier,M.Batchelor
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Key ref:
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J.Porter
et al.
(2009).
Discovery of 4-azaindoles as novel inhibitors of c-Met kinase.
Bioorg Med Chem Lett,
19,
2780-2784.
PubMed id:
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Date:
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19-Mar-09
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Release date:
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28-Apr-09
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PROCHECK
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Headers
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References
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P08581
(MET_HUMAN) -
Hepatocyte growth factor receptor from Homo sapiens
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Seq:
Struc:
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1390 a.a.
289 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Bioorg Med Chem Lett
19:2780-2784
(2009)
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PubMed id:
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Discovery of 4-azaindoles as novel inhibitors of c-Met kinase.
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J.Porter,
S.Lumb,
R.J.Franklin,
J.M.Gascon-Simorte,
M.Calmiano,
K.L.Riche,
B.Lallemand,
J.Keyaerts,
H.Edwards,
A.Maloney,
J.Delgado,
L.King,
A.Foley,
F.Lecomte,
J.Reuberson,
C.Meier,
M.Batchelor.
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ABSTRACT
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A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated
binding mode was confirmed by an X-ray crystal structure and series optimisation
was performed on the basis of this structure. Future directions for series
development are discussed.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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J.Caballero,
M.Quiliano,
J.H.Alzate-Morales,
M.Zimic,
and
E.Deharo
(2011).
Docking and quantitative structure-activity relationship studies for 3-fluoro-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yloxy)aniline, 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline, and 4-(4-amino-2-fluorophenoxy)-2-pyridinylamine derivatives as c-Met kinase inhibitors.
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J Comput Aided Mol Des,
25,
349-369.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
