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UniProt functional annotation for Q7ZZM2 | ||
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| UniProt code: Q7ZZM2. |
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| Organism: | |
Protobothrops jerdonii (Jerdon's pitviper) (Trimeresurus jerdonii). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Protobothrops. |
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| Function: | |
Recombinant protein inhibits the adhesion of alpha-1/beta-1- K562 (ITGA1/ITGB1) cells to collagen IV with an IC(50) of 80 nM. {ECO:0000269|PubMed:16215260, ECO:0000269|PubMed:21656569}. |
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| Subunit: | |
Monomer. {ECO:0000250}. |
| Subcellular location: | |
Secreted {ECO:0000305|PubMed:16215260}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000305|PubMed:21656569}. |
| Ptm: | |
Two conformers are found, they may differ by their disulfide bond connectivities. Conformer 2 is 33 times less active than conformer 1. Conformer 2 may represent a non-native protein (PubMed:16215260). {ECO:0000269|PubMed:16215260}. |
| Ptm: | |
The C-terminal dipeptide may be post-translationally removed, as seen in disintegrins that possess a KTS integrin-binding motif. |
| Miscellaneous: | |
Does not show inhibitory activity toward alpha-IIb/beta- 3 (ITGA2B/ITGB3), alpha-V/beta-3 (ITGAV/ITGB3), alpha-2/beta-1 (ITGA2/ITGB1), alpha-5/beta-1 (ITGA5/ITGB1), alpha-4/beta-1 (ITGA4/ITGB1), alpha-6/beta-1 (ITGA6/ITGB1), and alpha-9/beta-1 (ITGA9/ITGB1). {ECO:0000305|PubMed:16215260}. |
| Similarity: | |
Belongs to the disintegrin family. Short disintegrin subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.