UniProt functional annotation for P0C6E9

UniProt code: P0C6E9.

Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio.
 
Function: Cleaves the terminal sialic acid (N-acetyl neuraminic acid) from carbohydrate chains in glycoproteins providing free sialic acid which can be used as carbon and energy sources. Sialidases have been suggested to be pathogenic factors in microbial infections. Facilitates cholera toxin binding to host intestinal epithelial cells by converting cell surface polysialogangliosides to GM1 monogangliosides.
 
Catalytic activity: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Cofactor: Calcium.
Subunit: Monomer. {ECO:0000305}.
Subcellular location: Secreted.
Induction: May be controlled by sialic acid availability and a growth-phase-dependent mechanism.
Similarity: Belongs to the glycosyl hydrolase 33 family. {ECO:0000305}.
Similarity: Contains 4 BNR repeats. {ECO:0000305}.
Sequence caution: Sequence=AAF94933.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.