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* Residue conservation analysis
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PDB id:
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Immune system
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Title:
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Anti citrullinated collagen type 2 antibody acc4 in complex with a citrullinated peptide
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Structure:
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Anti-citrullinated collagen type ii fab acc4. Chain: a, c. Anti-citrullinated collagen type ii fab acc4. Chain: b, d. Collagen derived peptide pcii-cit1. Chain: e, f. Engineered: yes. Other_details: based on the c1 (359-367) epitope of collagen type ii with a cirulline at position 360
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Source:
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Mus musculus. Mouse. Organism_taxid: 10090. Strain: dba/1. Cell_line: monoclonal b cell hybridoma. Organ: spleen. Synthetic: yes. Organism_taxid: 10090
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Resolution:
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2.21Å
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R-factor:
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0.237
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R-free:
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0.285
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Authors:
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H.Uysal,R.Bockermann,K.S.Nandakumar,B.Sehnert,E.Bajtner,A.Engstrom, G.Serre,H.Burkhardt,M.M.G.M.Thunnissen,R.Holmdahl
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Key ref:
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H.Uysal
et al.
(2009).
Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
J Exp Med,
206,
449-462.
PubMed id:
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Date:
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17-Dec-08
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Release date:
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24-Feb-09
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PROCHECK
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Headers
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References
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J Exp Med
206:449-462
(2009)
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PubMed id:
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Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
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H.Uysal,
R.Bockermann,
K.S.Nandakumar,
B.Sehnert,
E.Bajtner,
A.Engström,
G.Serre,
H.Burkhardt,
M.M.Thunnissen,
R.Holmdahl.
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ABSTRACT
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Antibodies to citrulline-modified proteins have a high diagnostic value in
rheumatoid arthritis (RA). However, their biological role in disease development
is still unclear. To obtain insight into this question, a panel of mouse
monoclonal antibodies was generated against a major triple helical collagen type
II (CII) epitope (position 359-369; ARGLTGRPGDA) with or without arginines
modified by citrullination. These antibodies bind cartilage and synovial tissue,
and mediate arthritis in mice. Detection of citrullinated CII from RA patients'
synovial fluid demonstrates that cartilage-derived CII is indeed citrullinated
in vivo. The structure determination of a Fab fragment of one of these
antibodies in complex with a citrullinated peptide showed a surprising beta-turn
conformation of the peptide and provided information on citrulline recognition.
Based on these findings, we propose that autoimmunity to CII, leading to the
production of antibodies specific for both native and citrullinated CII, is an
important pathogenic factor in the development of RA.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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B.E.Gilliam,
M.R.Reed,
A.K.Chauhan,
A.B.Dehlendorf,
and
T.L.Moore
(2011).
Evidence of fibrinogen as a target of citrullination in IgM rheumatoid factor-positive polyarticular juvenile idiopathic arthritis.
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Pediatr Rheumatol Online J,
9,
8.
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H.Yu,
Y.H.Yang,
R.Rajaiah,
and
K.D.Moudgil
(2011).
Nicotine-induced differential modulation of autoimmune arthritis in the Lewis rat involves changes in interleukin-17 and anti-cyclic citrullinated peptide antibodies.
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Arthritis Rheum,
63,
981-991.
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L.A.Trouw,
and
T.W.Huizinga
(2011).
Which elements of the criteria for RA are stable over time?
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Rheumatology (Oxford),
50,
248-249.
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|
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L.Klareskog,
V.Malmström,
K.Lundberg,
L.Padyukov,
and
L.Alfredsson
(2011).
Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis.
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Semin Immunol,
23,
92-98.
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N.A.Daha,
and
R.E.Toes
(2011).
Rheumatoid arthritis: Are ACPA-positive and ACPA-negative RA the same disease?
|
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Nat Rev Rheumatol,
7,
202-203.
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A.Ercan,
J.Cui,
D.E.Chatterton,
K.D.Deane,
M.M.Hazen,
W.Brintnell,
C.I.O'Donnell,
L.A.Derber,
M.E.Weinblatt,
N.A.Shadick,
D.A.Bell,
E.Cairns,
D.H.Solomon,
V.M.Holers,
P.M.Rudd,
and
D.M.Lee
(2010).
Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis.
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Arthritis Rheum,
62,
2239-2248.
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A.J.Schuerwegh,
A.Ioan-Facsinay,
A.L.Dorjée,
J.Roos,
I.M.Bajema,
E.I.van der Voort,
T.W.Huizinga,
and
R.E.Toes
(2010).
Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis.
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Proc Natl Acad Sci U S A,
107,
2586-2591.
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A.M.Croxford,
D.Crombie,
D.McNaughton,
R.Holmdahl,
K.S.Nandakumar,
and
M.J.Rowley
(2010).
Specific antibody protection of the extracellular cartilage matrix against collagen antibody-induced damage.
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Arthritis Rheum,
62,
3374-3384.
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D.L.Scott,
F.Wolfe,
and
T.W.Huizinga
(2010).
Rheumatoid arthritis.
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Lancet,
376,
1094-1108.
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H.Uysal,
K.S.Nandakumar,
C.Kessel,
S.Haag,
S.Carlsen,
H.Burkhardt,
and
R.Holmdahl
(2010).
Antibodies to citrullinated proteins: molecular interactions and arthritogenicity.
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Immunol Rev,
233,
9.
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J.A.O'Daly,
J.P.Gleason,
G.Peña,
and
I.Colorado
(2010).
Purified proteins from Leishmania amastigotes-induced delayed type hypersensitivity reactions and remission of collagen-induced arthritis in animal models.
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Arch Dermatol Res,
302,
567-581.
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K.D.Deane,
J.M.Norris,
and
V.M.Holers
(2010).
Preclinical rheumatoid arthritis: identification, evaluation, and future directions for investigation.
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Rheum Dis Clin North Am,
36,
213-241.
|
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K.S.Nandakumar
(2010).
Pathogenic antibody recognition of cartilage.
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Cell Tissue Res,
339,
213-220.
|
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K.S.Nandakumar,
A.Jansson,
B.Xu,
N.Rydell,
A.M.Blom,
and
R.Holmdahl
(2010).
A recombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritis.
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PLoS One,
5,
e13511.
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M.Behrens,
T.Trejo,
H.Luthra,
M.Griffiths,
C.S.David,
and
V.Taneja
(2010).
Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice.
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J Autoimmun,
35,
1-9.
|
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N.Wegner,
K.Lundberg,
A.Kinloch,
B.Fisher,
V.Malmström,
M.Feldmann,
and
P.J.Venables
(2010).
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis.
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Immunol Rev,
233,
34-54.
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P.Mydel,
Z.Wang,
M.Brisslert,
A.Hellvard,
L.E.Dahlberg,
S.L.Hazen,
and
M.Bokarewa
(2010).
Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis.
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J Immunol,
184,
6882-6890.
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S.S.Deo,
R.R.Shetty,
K.J.Mistry,
and
A.R.Chogle
(2010).
Detection of Viral Citrullinated Peptide Antibodies Directed Against EBV or VCP: In Early Rheumatoid Arthritis Patients of Indian Origin.
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J Lab Physicians,
2,
93-99.
|
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|
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|
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T.M.Lindstrom,
and
W.H.Robinson
(2010).
Rheumatoid arthritis: a role for immunosenescence?
|
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J Am Geriatr Soc,
58,
1565-1575.
|
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|
|
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|
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H.U.Scherer,
and
G.R.Burmester
(2009).
A clinical perspective of rheumatoid arthritis.
|
| |
Eur J Immunol,
39,
2044-2048.
|
|
|
|
|
|
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J.J.Goronzy,
and
C.M.Weyand
(2009).
Developments in the scientific understanding of rheumatoid arthritis.
|
| |
Arthritis Res Ther,
11,
249.
|
|
|
|
|
|
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L.A.Trouw,
E.M.Haisma,
E.W.Levarht,
D.van der Woude,
A.Ioan-Facsinay,
M.R.Daha,
T.W.Huizinga,
and
R.E.Toes
(2009).
Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways.
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| |
Arthritis Rheum,
60,
1923-1931.
|
|
|
|
|
|
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W.B.van den Berg
(2009).
Lessons from animal models of arthritis over the past decade.
|
| |
Arthritis Res Ther,
11,
250.
|
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
