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PDBsum entry 2w4o
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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Crystal structure of human camk4 in complex with 4-amino(sulfamoyl- phenylamino)-triazole-carbothioic acid (2,6-difluoro-phenyl)-amide)
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Structure:
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Calcium/calmodulin-dependent protein kinase type iv. Chain: a. Fragment: residues 15-340. Synonym: cam kinase-gr, camk4a. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: calm.
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Resolution:
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2.17Å
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R-factor:
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0.216
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R-free:
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0.237
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Authors:
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J.R.C.Muniz,P.Rellos,O.Gileadi,O.Fedorov,P.Filippakopoulos,E.Salah, A.Pike,C.Phillips,F.Niesen,L.Shrestha,N.Burgess-Brown,A.Bullock, G.Berridge,F.Von Delft,A.M.Edwards,C.Bountra,C.H.Arrowsmith, J.Weigelt,S.Knapp
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Key ref:
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J.R.C.Muniz
et al.
Crystal structure of human camk4 in complex with 4-Amino(sulfamoyl-Phenylamino)-Triazole- Carbothioic acid (2,6-Difluoro-Phenyl)-Amide).
To be published,
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Date:
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28-Nov-08
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Release date:
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20-Jan-09
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PROCHECK
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Headers
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References
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Q16566
(KCC4_HUMAN) -
Calcium/calmodulin-dependent protein kinase type IV from Homo sapiens
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Seq:
Struc:
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473 a.a.
278 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.7.11.17
- calcium/calmodulin-dependent protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Cofactor:
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Ca(2+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
