UniProt functional annotation for O60763



	UniProt functional annotation for O60763

UniProt code: O60763.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}.

Subunit: Homodimer. Dimerizes by parallel association of the tails, resulting in an elongated structure with two globular head domains side by side, and a long rod-like tail structure (Probable). Interacts with MIF. {ECO:0000269|PubMed:19247479, ECO:0000269|PubMed:19454686, ECO:0000305}.

Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:9478999}. Golgi apparatus membrane {ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:9478999}; Peripheral membrane protein {ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:9478999}. Note=Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes. {ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:9478999}.

Domain: Composed of a globular head, an elongated tail (coiled-coil) and a highly acidic C-terminal domain. {ECO:0000269|PubMed:19247479}.

Ptm: Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells. Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation. {ECO:0000269|PubMed:9478999}.

Similarity: Belongs to the VDP/USO1/EDE1 family. {ECO:0000305}.

Sequence caution: Sequence=AAH06398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250\|UniProtKB:P41542}.


Subunit:		Homodimer. Dimerizes by parallel association of the tails, resulting in an elongated structure with two globular head domains side by side, and a long rod-like tail structure (Probable). Interacts with MIF. {ECO:0000269\|PubMed:19247479, ECO:0000269\|PubMed:19454686, ECO:0000305}.
Subcellular location:		Cytoplasm, cytosol {ECO:0000269\|PubMed:19454686, ECO:0000269\|PubMed:9478999}. Golgi apparatus membrane {ECO:0000269\|PubMed:19454686, ECO:0000269\|PubMed:9478999}; Peripheral membrane protein {ECO:0000269\|PubMed:19454686, ECO:0000269\|PubMed:9478999}. Note=Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes. {ECO:0000269\|PubMed:19454686, ECO:0000269\|PubMed:9478999}.
Domain:		Composed of a globular head, an elongated tail (coiled-coil) and a highly acidic C-terminal domain. {ECO:0000269\|PubMed:19247479}.
Ptm:		Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells. Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation. {ECO:0000269\|PubMed:9478999}.
Similarity:		Belongs to the VDP/USO1/EDE1 family. {ECO:0000305}.
Sequence caution:		Sequence=AAH06398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};