PDBsum entry 2vx0

Transferase

PDB id: 2vx0

Contents

Protein chain

273 a.a.

Ligands

7X7

Metals

_MG ×3

Waters ×205

References listed in PDB file

Key reference

• Title: Inhibitors of the tyrosine kinase ephb4. Part 1: structure-Based design and optimization of a series of 2,4-Bis-Anilinopyrimidines.
• Authors: C.Bardelle, D.Cross, S.Davenport, J.G.Kettle, E.J.Ko, A.G.Leach, A.Mortlock, J.Read, N.J.Roberts, P.Robins, E.J.Williams.
• Ref.: Bioorg Med Chem Lett, 2008, 18, 2776-2780.
• PubMed id: 18434142

Note: In the PDB file this reference is annotated as "TO BE PUBLISHED". The citation details given above have been manually determined.

Abstract

A series of bis-anilinopyrimidines have been identified as potent inhibitors of the tyrosine kinase EphB4. Structural information from two alternative series identified from screening efforts was combined to identify the initial leads.

Secondary reference #1

• Title: Inhibitors of the tyrosine kinase ephb4. Part 2: structure-Based discovery and optimisation of 3,5-Bis substituted anilinopyrimidines.
• Authors: C.Bardelle, T.Coleman, D.Cross, S.Davenport, J.G.Kettle, E.J.Ko, A.G.Leach, A.Mortlock, J.Read, N.J.Roberts, P.Robins, E.J.Williams.
• Ref.: Bioorg Med Chem Lett, 2008, 18, 5717-5721.
• PubMed id: 18851911