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PDBsum entry 2vwn
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Blood clotting
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PDB id
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2vwn
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References listed in PDB file
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Key reference
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Title
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Design of novel aminopyrrolidine factor xa inhibitors from a screening hit.
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Authors
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K.G.Zbinden,
L.Anselm,
D.W.Banner,
J.Benz,
F.Blasco,
G.Décoret,
J.Himber,
B.Kuhn,
N.Panday,
F.Ricklin,
P.Risch,
D.Schlatter,
M.Stahl,
S.Thomi,
R.Unger,
W.Haap.
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Ref.
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Eur J Med Chem, 2009,
44,
2787-2795.
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PubMed id
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Abstract
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Starting from a hit identified by focused screening, 3-aminopyrrolidine factor
Xa inhibitors were designed. The binding mode as determined by X-ray structural
analysis as well as the pharmacokinetic behaviour of selected compounds is
discussed.
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