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PDBsum entry 2vn9
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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Crystal structure of human calcium calmodulin dependent protein kinase ii delta isoform 1, camkd
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Structure:
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Calcium/calmodulin-dependent protein kinase type ii delta chain. Chain: a, b. Fragment: kinase domain, residues 11-309. Synonym: cam-kinase ii delta chain, cam kinase ii subunit delta, camk-ii subunit delta, calcium calmodulin dependent protein kinase ii delta isoform 1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: r3-prare2.
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Resolution:
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2.30Å
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R-factor:
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0.213
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R-free:
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0.248
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Authors:
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A.K.Roos,P.Rellos,E.Salah,A.C.W.Pike,O.Fedorov,E.S.Pilka,F.Von Delft, C.H.Arrowsmith,J.Weigelt,A.Edwards,C.Bountra,S.Knapp
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Key ref:
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P.Rellos
et al.
(2010).
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
Plos Biol,
8,
e1000426.
PubMed id:
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Date:
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31-Jan-08
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Release date:
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26-Feb-08
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PROCHECK
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Headers
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References
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Q13557
(KCC2D_HUMAN) -
Calcium/calmodulin-dependent protein kinase type II subunit delta from Homo sapiens
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Seq:
Struc:
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499 a.a.
301 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.2.7.11.17
- calcium/calmodulin-dependent protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Cofactor:
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Ca(2+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Plos Biol
8:e1000426
(2010)
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PubMed id:
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Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
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P.Rellos,
A.C.Pike,
F.H.Niesen,
E.Salah,
W.H.Lee,
F.von Delft,
S.Knapp.
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ABSTRACT
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Links
