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UniProt functional annotation for Q7SIB6 | ||
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| UniProt code: Q7SIB6. |
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| Organism: | |
Geobacillus stearothermophilus (Bacillus stearothermophilus). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus. |
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| Function: | |
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. {ECO:0000256|HAMAP-Rule:MF_00051}. |
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| Catalytic activity: | |
Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine; Xref=Rhea:RHEA:15481, ChEBI:CHEBI:15377, ChEBI:CHEBI:15636, ChEBI:CHEBI:33384, ChEBI:CHEBI:57305, ChEBI:CHEBI:57453; EC=2.1.2.1; Evidence={ECO:0000256|HAMAP-Rule:MF_00051}; |
| Cofactor: | |
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000256|ARBA:ARBA00001933, ECO:0000256|HAMAP-Rule:MF_00051, ECO:0000256|PIRSR:PIRSR000412-50}; |
| Pathway: | |
Amino-acid biosynthesis; glycine biosynthesis; glycine from L- serine: step 1/1. {ECO:0000256|ARBA:ARBA00004697, ECO:0000256|HAMAP- Rule:MF_00051}. |
| Pathway: | |
One-carbon metabolism; tetrahydrofolate interconversion. {ECO:0000256|HAMAP-Rule:MF_00051}. |
| Subunit: | |
Homodimer. {ECO:0000256|HAMAP-Rule:MF_00051}. |
| Subcellular location: | |
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00051}. |
| Similarity: | |
Belongs to the SHMT family. {ECO:0000256|ARBA:ARBA00006376, ECO:0000256|HAMAP-Rule:MF_00051}. |
Annotations taken from UniProtKB at the EBI.