UniProt functional annotation for P07149

UniProt code: P07149.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
 
Function: Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
 
Catalytic activity: Acetyl-CoA + n malonyl-CoA + 2n NADPH = long- chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+).
Catalytic activity: Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].
Catalytic activity: Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].
Catalytic activity: A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O.
Catalytic activity: An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.
Catalytic activity: Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl- carrier-protein] + oleate.
Subunit: [Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).
Miscellaneous: Present with 91800 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity: Belongs to the fungal fatty acid synthetase subunit beta family. {ECO:0000305}.
Similarity: Contains 1 MaoC-like domain. {ECO:0000305}.
Sequence caution: Sequence=CAA27616.1; Type=Frameshift; Positions=1845, 1948, 2017; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.