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PDBsum entry 2vh6
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References listed in PDB file
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Key reference
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Title
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Structure and property based design of factor xa inhibitors: pyrrolidin-2-Ones with biaryl p4 motifs.
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Authors
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R.J.Young,
A.D.Borthwick,
D.Brown,
C.L.Burns-Kurtis,
M.Campbell,
C.Chan,
M.Charbaut,
C.W.Chung,
M.A.Convery,
H.A.Kelly,
N.Paul king,
S.Kleanthous,
A.M.Mason,
A.J.Pateman,
A.N.Patikis,
I.L.Pinto,
D.R.Pollard,
S.Senger,
G.P.Shah,
J.R.Toomey,
N.S.Watson,
H.E.Weston.
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Ref.
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Bioorg Med Chem Lett, 2008,
18,
23-27.
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PubMed id
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Abstract
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Structure and property based drug design was exploited in the synthesis of
sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating
biaryl P4 groups, producing highly potent inhibitors with encouraging oral
pharmacokinetic profiles and significant but sub-optimal anticoagulant
activities.
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