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PDBsum entry 2vey
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References listed in PDB file
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Key reference
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Title
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Isothiazolidinone inhibitors of ptp1b containing imidazoles and imidazolines.
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Authors
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B.Douty,
B.Wayland,
P.J.Ala,
M.J.Bower,
J.Pruitt,
L.Bostrom,
M.Wei,
R.Klabe,
L.Gonneville,
R.Wynn,
T.C.Burn,
P.C.Liu,
A.P.Combs,
E.W.Yue.
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Ref.
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Bioorg Med Chem Lett, 2008,
18,
66-71.
[DOI no: ]
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PubMed id
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Abstract
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The structure-based design and synthesis of isothiazolidinone (IZD) inhibitors
of PTP1B containing imidazoles and imidazolines and their modification to
interact with the B site of PTP1B are described here. The X-ray crystal
structures of 3I and 4I complexed with PTP1B were solved and revealed the
inhibitors are interacting extensively with the B site of the enzyme.
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