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PDBsum entry 2vew

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Hydrolase PDB id
2vew
Jmol
Contents
Protein chain
297 a.a.
Ligands
IZ3
Metals
_MG
Waters ×295

References listed in PDB file
Key reference
Title Isothiazolidinone inhibitors of ptp1b containing imidazoles and imidazolines.
Authors B.Douty, B.Wayland, P.J.Ala, M.J.Bower, J.Pruitt, L.Bostrom, M.Wei, R.Klabe, L.Gonneville, R.Wynn, T.C.Burn, P.C.Liu, A.P.Combs, E.W.Yue.
Ref. Bioorg Med Chem Lett, 2008, 18, 66-71. [DOI no: 10.1016/j.bmcl.2007.11.012]
PubMed id 18037290
Abstract
The structure-based design and synthesis of isothiazolidinone (IZD) inhibitors of PTP1B containing imidazoles and imidazolines and their modification to interact with the B site of PTP1B are described here. The X-ray crystal structures of 3I and 4I complexed with PTP1B were solved and revealed the inhibitors are interacting extensively with the B site of the enzyme.
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 Headers