 |
PDBsum entry 2vev
|
|
|
|
References listed in PDB file
|
 |
|
Key reference
|
|
|
Title
|
|
Isothiazolidinone inhibitors of ptp1b containing imidazoles and imidazolines.
|
|
|
Authors
|
|
B.Douty,
B.Wayland,
P.J.Ala,
M.J.Bower,
J.Pruitt,
L.Bostrom,
M.Wei,
R.Klabe,
L.Gonneville,
R.Wynn,
T.C.Burn,
P.C.Liu,
A.P.Combs,
E.W.Yue.
|
|
|
Ref.
|
|
Bioorg Med Chem Lett, 2008,
18,
66-71.
[DOI no: ]
|
|
|
PubMed id
|
|
|
|
|
|
|
|
|
Abstract
|
|
|
The structure-based design and synthesis of isothiazolidinone (IZD) inhibitors
of PTP1B containing imidazoles and imidazolines and their modification to
interact with the B site of PTP1B are described here. The X-ray crystal
structures of 3I and 4I complexed with PTP1B were solved and revealed the
inhibitors are interacting extensively with the B site of the enzyme.
|
|
|
|
|
|
|
