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UniProt functional annotation for Q03774 | ||
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| UniProt code: Q03774. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. {ECO:0000255|HAMAP-Rule:MF_03056, ECO:0000269|PubMed:15811913, ECO:0000269|PubMed:16387656, ECO:0000269|PubMed:17382321, ECO:0000269|PubMed:18184583, ECO:0000269|PubMed:26416026}. |
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| Pathway: | |
tRNA modification; N(7)-methylguanine-tRNA biosynthesis. {ECO:0000269|PubMed:26416026}. |
| Subunit: | |
Forms a heterodimer with the catalytic subunit TRM8. {ECO:0000255|HAMAP-Rule:MF_03056, ECO:0000269|PubMed:18184583}. |
| Subcellular location: | |
Nucleus {ECO:0000255|HAMAP-Rule:MF_03056, ECO:0000269|PubMed:14562095}. |
| Miscellaneous: | |
Present with 5910 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the WD repeat TRM82 family. {ECO:0000255|HAMAP- Rule:MF_03056}. |
Annotations taken from UniProtKB at the EBI.