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UniProt functional annotation for Q9JJV2 | ||
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| UniProt code: Q9JJV2. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. |
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| Subunit: | |
Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio (By similarity). Interacts with PFN2 (PubMed:19403918). {ECO:0000250|UniProtKB:P35080, ECO:0000269|PubMed:19403918}. |
| Subcellular location: | |
Cytoplasm, cytoskeleton. |
| Tissue specificity: | |
Isoform IIa is the main isoform and is abundant in brain. Isoform IIb is a minor isoform. |
| Similarity: | |
Belongs to the profilin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.