UniProt functional annotation for P55290



	UniProt functional annotation for P55290

UniProt code: P55290.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. {ECO:0000269|PubMed:10737605}.

Subunit: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1- EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape. {ECO:0000250}.

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.

Tissue specificity: Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord. {ECO:0000269|PubMed:10737605, ECO:0000269|PubMed:8673923}.

Developmental stage: Expressed at higher levels in adult brain than in developing brain. {ECO:0000269|PubMed:10737605}.

Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO:0000250}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. {ECO:0000269\|PubMed:10737605}.


Subunit:		By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1- EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape. {ECO:0000250}.
Subcellular location:		Cell membrane; Lipid-anchor, GPI-anchor.
Tissue specificity:		Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord. {ECO:0000269\|PubMed:10737605, ECO:0000269\|PubMed:8673923}.
Developmental stage:		Expressed at higher levels in adult brain than in developing brain. {ECO:0000269\|PubMed:10737605}.
Domain:		Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO:0000250}.