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PDBsum entry 2uyl
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Immune system
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PDB id
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2uyl
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References listed in PDB file
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Key reference
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Title
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Crystal structure of a monoclonal antibody directed against an antigenic determinant common to ogawa and inaba serotypes of vibrio cholerae o1.
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Authors
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F.Ahmed,
G.André-Leroux,
A.Haouz,
A.Boutonnier,
M.Delepierre,
F.Qadri,
F.Nato,
J.M.Fournier,
P.M.Alzari.
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Ref.
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Proteins, 2008,
70,
284-288.
[DOI no: ]
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PubMed id
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Abstract
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No abstract given.
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Figure 1.
Figure 1. Crystal structure of Fab F-22-30. (a) Final electron
density map (contoured at 1.2  )
of a segment from the H3 hypervariable loop (Ser105H-Trp109H).
(b) Molecular surface of the antibody recombination site. The
positions of some hypervariable loops are indicated. Note a deep
pocket delimited by the L1, L3, and H3 hypervariable loops. (c)
A difference Fourier (F[o] - F[c]) map contoured at 3 suggests
that an unidentified molecule binds to this pocket in the
crystal.
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Figure 2.
Figure 2. Putative model of 3-deoxy-L-glycero-tetronic acid
docked into the antigen-binding site. Amino acid residues that
could participate in protein-ligand H-bonds are indicated. The
direction of the O-PS homopolymer would be roughly perpendicular
to the plane of the figure.
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The above figures are
reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2008,
70,
284-288)
copyright 2008.
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