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PDBsum entry 2uyl
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Immune system
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PDB id
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2uyl
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Contents |
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* Residue conservation analysis
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PDB id:
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Immune system
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Title:
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Crystal structure of a monoclonal antibody directed against an antigenic determinant common to ogawa and inaba serotypes of vibrio cholerae o1
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Structure:
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Monoclonal antibody f-22-30. Chain: a, m, v, x. Monoclonal antibody f-22-30. Chain: b, n, w, y
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Source:
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Mus musculus. Mouse. Organism_taxid: 10090. Cell_line: f-22-30 murin hybridoma. Cell_line: f-22-30 murin hybridoma
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Resolution:
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2.50Å
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R-factor:
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0.213
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R-free:
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0.257
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Authors:
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F.Ahmed,A.Haouz,F.Nato,J.M.Fournier,P.M.Alzari
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Key ref:
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F.Ahmed
et al.
(2008).
Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1.
Proteins,
70,
284-288.
PubMed id:
DOI:
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Date:
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10-Apr-07
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Release date:
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13-May-08
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PROCHECK
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Headers
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References
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DOI no:
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Proteins
70:284-288
(2008)
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PubMed id:
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Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1.
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F.Ahmed,
G.André-Leroux,
A.Haouz,
A.Boutonnier,
M.Delepierre,
F.Qadri,
F.Nato,
J.M.Fournier,
P.M.Alzari.
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ABSTRACT
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Selected figure(s)
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Figure 1.
Figure 1. Crystal structure of Fab F-22-30. (a) Final electron
density map (contoured at 1.2  )
of a segment from the H3 hypervariable loop (Ser105H-Trp109H).
(b) Molecular surface of the antibody recombination site. The
positions of some hypervariable loops are indicated. Note a deep
pocket delimited by the L1, L3, and H3 hypervariable loops. (c)
A difference Fourier (F[o] - F[c]) map contoured at 3 suggests
that an unidentified molecule binds to this pocket in the
crystal.
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Figure 2.
Figure 2. Putative model of 3-deoxy-L-glycero-tetronic acid
docked into the antigen-binding site. Amino acid residues that
could participate in protein-ligand H-bonds are indicated. The
direction of the O-PS homopolymer would be roughly perpendicular
to the plane of the figure.
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The above figures are
reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2008,
70,
284-288)
copyright 2008.
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Figures were
selected
by the author.
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Links
