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PDBsum entry 2uv8

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Top Page protein ligands Protein-protein interface(s) links
Transferase PDB id
2uv8
Jmol
Contents
Protein chains
1614 a.a.
2033 a.a.
Ligands
FMN ×3
HEADER    TRANSFERASE                             09-MAR-07   2UV8
TITLE     CRYSTAL STRUCTURE OF YEAST FATTY ACID SYNTHASE WITH STALLED
TITLE    2 ACYL CARRIER PROTEIN AT 3.1 ANGSTROM RESOLUTION
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: FATTY ACID SYNTHASE SUBUNIT ALPHA (FAS2);
COMPND   3 CHAIN: A, B, C;
COMPND   4 SYNONYM: FATTY ACID SYNTHASE;
COMPND   5 EC: 2.3.1.86;
COMPND   6 OTHER_DETAILS: PHOSPHOPANTETHEINE PROSTHETIC GROUP
COMPND   7  COVALENTLY LINKED TO SERINE 180 OF CHAIN A, B, C;
COMPND   8 MOL_ID: 2;
COMPND   9 MOLECULE: FATTY ACID SYNTHASE SUBUNIT BETA (FAS1);
COMPND  10 CHAIN: G, H, I;
COMPND  11 SYNONYM: FATTY ACID SYNTHASE;
COMPND  12 EC: 2.3.1.86
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;
SOURCE   3 ORGANISM_COMMON: BAKER'S YEAST;
SOURCE   4 ORGANISM_TAXID: 4932;
SOURCE   5 MOL_ID: 2;
SOURCE   6 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;
SOURCE   7 ORGANISM_COMMON: BAKER'S YEAST;
SOURCE   8 ORGANISM_TAXID: 4932
KEYWDS    FATTY ACID BIOSYNTHESIS, MALONYL/PALMITOYL TRANSFERASE,
KEYWDS   2 PHOSPHOPANTETHEINE, FATTY ACID SYNTHASE, TRANSFERASE,
KEYWDS   3 OXIDOREDUCTASE, LIPID SYNTHESIS, SUBSTRATE SHUTTLING, ACYL
KEYWDS   4 CARRIER PROTEIN, KETOACYL REDUCTASE, ACETYL TRANSFERASE,
KEYWDS   5 ENOYL REDUCTASE, PHOSPHORYLATION, KETOACYL SYNTHASE, FATTY
KEYWDS   6 ACID SYNTHESIS, MULTIFUNCTIONAL ENZYME, NAD, NADP, LYASE,
KEYWDS   7 YEAST, HYDROLASE, DEHYDRATASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.LEIBUNDGUT,S.JENNI,C.FRICK,N.BAN
REVDAT   2   24-FEB-09 2UV8    1       VERSN
REVDAT   1   17-APR-07 2UV8    0
JRNL        AUTH   M.LEIBUNDGUT,S.JENNI,C.FRICK,N.BAN
JRNL        TITL   STRUCTURAL BASIS FOR SUBSTRATE DELIVERY BY ACYL
JRNL        TITL 2 CARRIER PROTEIN IN THE YEAST FATTY ACID SYNTHASE
JRNL        REF    SCIENCE                       V. 316   288 2007
JRNL        REFN                   ISSN 0036-8075
JRNL        PMID   17431182
JRNL        DOI    10.1126/SCIENCE.1138249
REMARK   2
REMARK   2 RESOLUTION.    3.10 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX.REFINE
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER
REMARK   3               : ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.1
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 12.0
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 86.1
REMARK   3   NUMBER OF REFLECTIONS             : 327347
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : NULL
REMARK   3   R VALUE            (WORKING SET) : 0.20
REMARK   3   FREE R VALUE                     : 0.25
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.0
REMARK   3   FREE R VALUE TEST SET COUNT      : 13730
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : NULL
REMARK   3   SOLVENT RADIUS     : NULL
REMARK   3   SHRINKAGE RADIUS   : NULL
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : NULL
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : NULL
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 73.9
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 72.9
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :   NULL           NULL
REMARK   3   ANGLE     :   NULL           NULL
REMARK   3   CHIRALITY :   NULL           NULL
REMARK   3   PLANARITY :   NULL           NULL
REMARK   3   DIHEDRAL  :   NULL           NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 2UV8 COMPLIES WITH FORMAT V. 3.15, 01-DEC-08
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 14-MAR-07.
REMARK 100 THE PDBE ID CODE IS EBI-31837.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : NULL
REMARK 200  TEMPERATURE           (KELVIN) : 100.0
REMARK 200  PH                             : 7.10
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SLS
REMARK 200  BEAMLINE                       : X06SA
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9999
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : CCD
REMARK 200  DETECTOR MANUFACTURER          : MARRESEARCH
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XSCALE
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 341077
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.100
REMARK 200  RESOLUTION RANGE LOW       (A) : 12.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 89.7
REMARK 200  DATA REDUNDANCY                : 5.800
REMARK 200  R MERGE                    (I) : 0.11000
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 12.9000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.10
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.27
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.3
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : 0.63000
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 2.400
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: PDB ENTRIES 2UVB AND 2UVC
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS  (%): 71.38
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 4.33
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: NULL
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 41 21 2
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,-Y,Z+1/2
REMARK 290       3555   -Y+1/2,X+1/2,Z+1/4
REMARK 290       4555   Y+1/2,-X+1/2,Z+3/4
REMARK 290       5555   -X+1/2,Y+1/2,-Z+1/4
REMARK 290       6555   X+1/2,-Y+1/2,-Z+3/4
REMARK 290       7555   Y,X,-Z
REMARK 290       8555   -Y,-X,-Z+1/2
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      392.15000
REMARK 290   SMTRY1   3  0.000000 -1.000000  0.000000      115.30000
REMARK 290   SMTRY2   3  1.000000  0.000000  0.000000      115.30000
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000      196.07500
REMARK 290   SMTRY1   4  0.000000  1.000000  0.000000      115.30000
REMARK 290   SMTRY2   4 -1.000000  0.000000  0.000000      115.30000
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000      588.22500
REMARK 290   SMTRY1   5 -1.000000  0.000000  0.000000      115.30000
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000      115.30000
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000      196.07500
REMARK 290   SMTRY1   6  1.000000  0.000000  0.000000      115.30000
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000      115.30000
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000      588.22500
REMARK 290   SMTRY1   7  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2   7  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   8  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2   8 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000      392.15000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY.  THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 GENERATING THE BIOMOLECULE
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE:  1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DODECAMERIC
REMARK 350 SOFTWARE USED: PQS
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, G, H, I
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350   BIOMT1   2  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT2   2  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     SER A    95
REMARK 465     GLU A    96
REMARK 465     LEU A    97
REMARK 465     ALA A    98
REMARK 465     ALA A    99
REMARK 465     LYS A   100
REMARK 465     GLU A   101
REMARK 465     GLU A   102
REMARK 465     PRO A   103
REMARK 465     ALA A   104
REMARK 465     LYS A   105
REMARK 465     GLU A   106
REMARK 465     GLU A   107
REMARK 465     ALA A   108
REMARK 465     PRO A   109
REMARK 465     ALA A   110
REMARK 465     PRO A   111
REMARK 465     THR A   112
REMARK 465     PRO A   113
REMARK 465     ALA A   114
REMARK 465     ALA A   115
REMARK 465     SER A   116
REMARK 465     ALA A   117
REMARK 465     PRO A   118
REMARK 465     ALA A   119
REMARK 465     PRO A   120
REMARK 465     ALA A   121
REMARK 465     ALA A   122
REMARK 465     ALA A   123
REMARK 465     ALA A   124
REMARK 465     PRO A   125
REMARK 465     ALA A   126
REMARK 465     PRO A   127
REMARK 465     VAL A   128
REMARK 465     ALA A   129
REMARK 465     ALA A   130
REMARK 465     ALA A   131
REMARK 465     ALA A   132
REMARK 465     PRO A   133
REMARK 465     ALA A   134
REMARK 465     ALA A   135
REMARK 465     ALA A   136
REMARK 465     ALA A   137
REMARK 465     ALA A   138
REMARK 465     GLU A   139
REMARK 465     SER A   303
REMARK 465     SER A   304
REMARK 465     ALA A   305
REMARK 465     ALA A   306
REMARK 465     SER A   307
REMARK 465     ALA A   308
REMARK 465     SER A   309
REMARK 465     GLY A   310
REMARK 465     ALA A   311
REMARK 465     ALA A   312
REMARK 465     GLY A   313
REMARK 465     ALA A   314
REMARK 465     GLY A   315
REMARK 465     ALA A   316
REMARK 465     ALA A   317
REMARK 465     ALA A   318
REMARK 465     GLY A   319
REMARK 465     ALA A   320
REMARK 465     ALA A   321
REMARK 465     MET A   322
REMARK 465     ILE A   323
REMARK 465     ASP A   324
REMARK 465     ALA A   325
REMARK 465     GLY A   326
REMARK 465     ALA A   327
REMARK 465     PRO A   541
REMARK 465     THR A   542
REMARK 465     ILE A   543
REMARK 465     GLU A   544
REMARK 465     GLU A   545
REMARK 465     ASP A   546
REMARK 465     LEU A   547
REMARK 465     THR A   548
REMARK 465     ARG A   549
REMARK 465     VAL A   550
REMARK 465     TYR A   551
REMARK 465     LYS A   552
REMARK 465     ALA A   553
REMARK 465     ILE A   554
REMARK 465     SER A   555
REMARK 465     ALA A   556
REMARK 465     GLN A   557
REMARK 465     ALA A   558
REMARK 465     ASP A   559
REMARK 465     LYS A   560
REMARK 465     GLN A   561
REMARK 465     ASP A   562
REMARK 465     ILE A   563
REMARK 465     SER A   564
REMARK 465     SER A   565
REMARK 465     SER A   566
REMARK 465     THR A   567
REMARK 465     ARG A   568
REMARK 465     VAL A   569
REMARK 465     GLU A   570
REMARK 465     PHE A   571
REMARK 465     GLU A   572
REMARK 465     LYS A   573
REMARK 465     LEU A   574
REMARK 465     TYR A   575
REMARK 465     SER A   576
REMARK 465     ASP A   577
REMARK 465     LEU A   578
REMARK 465     MET A   579
REMARK 465     LYS A   580
REMARK 465     PHE A   581
REMARK 465     LEU A   582
REMARK 465     GLU A   583
REMARK 465     SER A   584
REMARK 465     SER A   585
REMARK 465     LYS A   586
REMARK 465     GLU A   587
REMARK 465     ILE A   588
REMARK 465     ASP A   589
REMARK 465     PRO A   590
REMARK 465     SER A   591
REMARK 465     GLN A   592
REMARK 465     THR A   593
REMARK 465     THR A   594
REMARK 465     GLN A   595
REMARK 465     LEU A   596
REMARK 465     ALA A   597
REMARK 465     GLY A   598
REMARK 465     GLY A   876
REMARK 465     LEU A   877
REMARK 465     MET A   878
REMARK 465     SER A   879
REMARK 465     ALA A   880
REMARK 465     ASN A  1748
REMARK 465     THR A  1749
REMARK 465     ILE A  1750
REMARK 465     GLU A  1751
REMARK 465     THR A  1752
REMARK 465     ALA A  1753
REMARK 465     LYS A  1754
REMARK 465     MET A  1755
REMARK 465     ILE A  1756
REMARK 465     GLU A  1757
REMARK 465     ASN A  1758
REMARK 465     MET A  1759
REMARK 465     THR A  1760
REMARK 465     LYS A  1761
REMARK 465     GLU A  1762
REMARK 465     LYS A  1763
REMARK 465     VAL A  1764
REMARK 465     SER A  1765
REMARK 465     ASN A  1766
REMARK 465     GLY A  1767
REMARK 465     GLY A  1768
REMARK 465     VAL A  1769
REMARK 465     GLY A  1770
REMARK 465     VAL A  1771
REMARK 465     ASP A  1772
REMARK 465     VAL A  1773
REMARK 465     GLU A  1774
REMARK 465     LEU A  1775
REMARK 465     ILE A  1776
REMARK 465     THR A  1777
REMARK 465     SER A  1778
REMARK 465     ILE A  1779
REMARK 465     ASN A  1780
REMARK 465     VAL A  1781
REMARK 465     GLU A  1782
REMARK 465     ASN A  1783
REMARK 465     ASP A  1784
REMARK 465     THR A  1785
REMARK 465     PHE A  1786
REMARK 465     ILE A  1787
REMARK 465     GLU A  1788
REMARK 465     ARG A  1789
REMARK 465     ASN A  1790
REMARK 465     PHE A  1791
REMARK 465     THR A  1792
REMARK 465     PRO A  1793
REMARK 465     GLN A  1794
REMARK 465     GLU A  1795
REMARK 465     ILE A  1796
REMARK 465     GLU A  1797
REMARK 465     TYR A  1798
REMARK 465     CYS A  1799
REMARK 465     SER A  1800
REMARK 465     ALA A  1801
REMARK 465     GLN A  1802
REMARK 465     PRO A  1803
REMARK 465     SER A  1804
REMARK 465     VAL A  1805
REMARK 465     GLN A  1806
REMARK 465     SER A  1807
REMARK 465     SER A  1808
REMARK 465     PHE A  1809
REMARK 465     ALA A  1810
REMARK 465     GLY A  1811
REMARK 465     THR A  1812
REMARK 465     TRP A  1813
REMARK 465     SER A  1814
REMARK 465     ALA A  1815
REMARK 465     LYS A  1816
REMARK 465     GLU A  1817
REMARK 465     ALA A  1818
REMARK 465     VAL A  1819
REMARK 465     PHE A  1820
REMARK 465     LYS A  1821
REMARK 465     SER A  1822
REMARK 465     LEU A  1823
REMARK 465     GLY A  1824
REMARK 465     VAL A  1825
REMARK 465     LYS A  1826
REMARK 465     SER A  1827
REMARK 465     LEU A  1828
REMARK 465     GLY A  1829
REMARK 465     GLY A  1830
REMARK 465     GLY A  1831
REMARK 465     ALA A  1832
REMARK 465     ALA A  1833
REMARK 465     LEU A  1834
REMARK 465     LYS A  1835
REMARK 465     ASP A  1836
REMARK 465     ILE A  1837
REMARK 465     GLU A  1838
REMARK 465     ILE A  1839
REMARK 465     VAL A  1840
REMARK 465     ARG A  1841
REMARK 465     VAL A  1842
REMARK 465     ASN A  1843
REMARK 465     LYS A  1844
REMARK 465     ASN A  1845
REMARK 465     ALA A  1846
REMARK 465     PRO A  1847
REMARK 465     ALA A  1848
REMARK 465     VAL A  1849
REMARK 465     GLU A  1850
REMARK 465     LEU A  1851
REMARK 465     HIS A  1852
REMARK 465     GLY A  1853
REMARK 465     ASN A  1854
REMARK 465     ALA A  1855
REMARK 465     LYS A  1856
REMARK 465     LYS A  1857
REMARK 465     ALA A  1858
REMARK 465     ALA A  1859
REMARK 465     GLU A  1860
REMARK 465     GLU A  1861
REMARK 465     ALA A  1862
REMARK 465     GLY A  1863
REMARK 465     VAL A  1864
REMARK 465     THR A  1865
REMARK 465     ASP A  1866
REMARK 465     VAL A  1867
REMARK 465     LYS A  1868
REMARK 465     VAL A  1869
REMARK 465     SER A  1870
REMARK 465     ILE A  1871
REMARK 465     SER A  1872
REMARK 465     HIS A  1873
REMARK 465     ASP A  1874
REMARK 465     ASP A  1875
REMARK 465     LEU A  1876
REMARK 465     GLN A  1877
REMARK 465     ALA A  1878
REMARK 465     VAL A  1879
REMARK 465     ALA A  1880
REMARK 465     VAL A  1881
REMARK 465     ALA A  1882
REMARK 465     VAL A  1883
REMARK 465     SER A  1884
REMARK 465     THR A  1885
REMARK 465     LYS A  1886
REMARK 465     LYS A  1887
REMARK 465     SER B    95
REMARK 465     GLU B    96
REMARK 465     LEU B    97
REMARK 465     ALA B    98
REMARK 465     ALA B    99
REMARK 465     LYS B   100
REMARK 465     GLU B   101
REMARK 465     GLU B   102
REMARK 465     PRO B   103
REMARK 465     ALA B   104
REMARK 465     LYS B   105
REMARK 465     GLU B   106
REMARK 465     GLU B   107
REMARK 465     ALA B   108
REMARK 465     PRO B   109
REMARK 465     ALA B   110
REMARK 465     PRO B   111
REMARK 465     THR B   112
REMARK 465     PRO B   113
REMARK 465     ALA B   114
REMARK 465     ALA B   115
REMARK 465     SER B   116
REMARK 465     ALA B   117
REMARK 465     PRO B   118
REMARK 465     ALA B   119
REMARK 465     PRO B   120
REMARK 465     ALA B   121
REMARK 465     ALA B   122
REMARK 465     ALA B   123
REMARK 465     ALA B   124
REMARK 465     PRO B   125
REMARK 465     ALA B   126
REMARK 465     PRO B   127
REMARK 465     VAL B   128
REMARK 465     ALA B   129
REMARK 465     ALA B   130
REMARK 465     ALA B   131
REMARK 465     ALA B   132
REMARK 465     PRO B   133
REMARK 465     ALA B   134
REMARK 465     ALA B   135
REMARK 465     ALA B   136
REMARK 465     ALA B   137
REMARK 465     ALA B   138
REMARK 465     GLU B   139
REMARK 465     SER B   303
REMARK 465     SER B   304
REMARK 465     ALA B   305
REMARK 465     ALA B   306
REMARK 465     SER B   307
REMARK 465     ALA B   308
REMARK 465     SER B   309
REMARK 465     GLY B   310
REMARK 465     ALA B   311
REMARK 465     ALA B   312
REMARK 465     GLY B   313
REMARK 465     ALA B   314
REMARK 465     GLY B   315
REMARK 465     ALA B   316
REMARK 465     ALA B   317
REMARK 465     ALA B   318
REMARK 465     GLY B   319
REMARK 465     ALA B   320
REMARK 465     ALA B   321
REMARK 465     MET B   322
REMARK 465     ILE B   323
REMARK 465     ASP B   324
REMARK 465     ALA B   325
REMARK 465     GLY B   326
REMARK 465     ALA B   327
REMARK 465     PRO B   541
REMARK 465     THR B   542
REMARK 465     ILE B   543
REMARK 465     GLU B   544
REMARK 465     GLU B   545
REMARK 465     ASP B   546
REMARK 465     LEU B   547
REMARK 465     THR B   548
REMARK 465     ARG B   549
REMARK 465     VAL B   550
REMARK 465     TYR B   551
REMARK 465     LYS B   552
REMARK 465     ALA B   553
REMARK 465     ILE B   554
REMARK 465     SER B   555
REMARK 465     ALA B   556
REMARK 465     GLN B   557
REMARK 465     ALA B   558
REMARK 465     ASP B   559
REMARK 465     LYS B   560
REMARK 465     GLN B   561
REMARK 465     ASP B   562
REMARK 465     ILE B   563
REMARK 465     SER B   564
REMARK 465     SER B   565
REMARK 465     SER B   566
REMARK 465     THR B   567
REMARK 465     ARG B   568
REMARK 465     VAL B   569
REMARK 465     GLU B   570
REMARK 465     PHE B   571
REMARK 465     GLU B   572
REMARK 465     LYS B   573
REMARK 465     LEU B   574
REMARK 465     TYR B   575
REMARK 465     SER B   576
REMARK 465     ASP B   577
REMARK 465     LEU B   578
REMARK 465     MET B   579
REMARK 465     LYS B   580
REMARK 465     PHE B   581
REMARK 465     LEU B   582
REMARK 465     GLU B   583
REMARK 465     SER B   584
REMARK 465     SER B   585
REMARK 465     LYS B   586
REMARK 465     GLU B   587
REMARK 465     ILE B   588
REMARK 465     ASP B   589
REMARK 465     PRO B   590
REMARK 465     SER B   591
REMARK 465     GLN B   592
REMARK 465     THR B   593
REMARK 465     THR B   594
REMARK 465     GLN B   595
REMARK 465     LEU B   596
REMARK 465     ALA B   597
REMARK 465     GLY B   598
REMARK 465     GLY B   876
REMARK 465     LEU B   877
REMARK 465     MET B   878
REMARK 465     SER B   879
REMARK 465     ALA B   880
REMARK 465     ASN B  1748
REMARK 465     THR B  1749
REMARK 465     ILE B  1750
REMARK 465     GLU B  1751
REMARK 465     THR B  1752
REMARK 465     ALA B  1753
REMARK 465     LYS B  1754
REMARK 465     MET B  1755
REMARK 465     ILE B  1756
REMARK 465     GLU B  1757
REMARK 465     ASN B  1758
REMARK 465     MET B  1759
REMARK 465     THR B  1760
REMARK 465     LYS B  1761
REMARK 465     GLU B  1762
REMARK 465     LYS B  1763
REMARK 465     VAL B  1764
REMARK 465     SER B  1765
REMARK 465     ASN B  1766
REMARK 465     GLY B  1767
REMARK 465     GLY B  1768
REMARK 465     VAL B  1769
REMARK 465     GLY B  1770
REMARK 465     VAL B  1771
REMARK 465     ASP B  1772
REMARK 465     VAL B  1773
REMARK 465     GLU B  1774
REMARK 465     LEU B  1775
REMARK 465     ILE B  1776
REMARK 465     THR B  1777
REMARK 465     SER B  1778
REMARK 465     ILE B  1779
REMARK 465     ASN B  1780
REMARK 465     VAL B  1781
REMARK 465     GLU B  1782
REMARK 465     ASN B  1783
REMARK 465     ASP B  1784
REMARK 465     THR B  1785
REMARK 465     PHE B  1786
REMARK 465     ILE B  1787
REMARK 465     GLU B  1788
REMARK 465     ARG B  1789
REMARK 465     ASN B  1790
REMARK 465     PHE B  1791
REMARK 465     THR B  1792
REMARK 465     PRO B  1793
REMARK 465     GLN B  1794
REMARK 465     GLU B  1795
REMARK 465     ILE B  1796
REMARK 465     GLU B  1797
REMARK 465     TYR B  1798
REMARK 465     CYS B  1799
REMARK 465     SER B  1800
REMARK 465     ALA B  1801
REMARK 465     GLN B  1802
REMARK 465     PRO B  1803
REMARK 465     SER B  1804
REMARK 465     VAL B  1805
REMARK 465     GLN B  1806
REMARK 465     SER B  1807
REMARK 465     SER B  1808
REMARK 465     PHE B  1809
REMARK 465     ALA B  1810
REMARK 465     GLY B  1811
REMARK 465     THR B  1812
REMARK 465     TRP B  1813
REMARK 465     SER B  1814
REMARK 465     ALA B  1815
REMARK 465     LYS B  1816
REMARK 465     GLU B  1817
REMARK 465     ALA B  1818
REMARK 465     VAL B  1819
REMARK 465     PHE B  1820
REMARK 465     LYS B  1821
REMARK 465     SER B  1822
REMARK 465     LEU B  1823
REMARK 465     GLY B  1824
REMARK 465     VAL B  1825
REMARK 465     LYS B  1826
REMARK 465     SER B  1827
REMARK 465     LEU B  1828
REMARK 465     GLY B  1829
REMARK 465     GLY B  1830
REMARK 465     GLY B  1831
REMARK 465     ALA B  1832
REMARK 465     ALA B  1833
REMARK 465     LEU B  1834
REMARK 465     LYS B  1835
REMARK 465     ASP B  1836
REMARK 465     ILE B  1837
REMARK 465     GLU B  1838
REMARK 465     ILE B  1839
REMARK 465     VAL B  1840
REMARK 465     ARG B  1841
REMARK 465     VAL B  1842
REMARK 465     ASN B  1843
REMARK 465     LYS B  1844
REMARK 465     ASN B  1845
REMARK 465     ALA B  1846
REMARK 465     PRO B  1847
REMARK 465     ALA B  1848
REMARK 465     VAL B  1849
REMARK 465     GLU B  1850
REMARK 465     LEU B  1851
REMARK 465     HIS B  1852
REMARK 465     GLY B  1853
REMARK 465     ASN B  1854
REMARK 465     ALA B  1855
REMARK 465     LYS B  1856
REMARK 465     LYS B  1857
REMARK 465     ALA B  1858
REMARK 465     ALA B  1859
REMARK 465     GLU B  1860
REMARK 465     GLU B  1861
REMARK 465     ALA B  1862
REMARK 465     GLY B  1863
REMARK 465     VAL B  1864
REMARK 465     THR B  1865
REMARK 465     ASP B  1866
REMARK 465     VAL B  1867
REMARK 465     LYS B  1868
REMARK 465     VAL B  1869
REMARK 465     SER B  1870
REMARK 465     ILE B  1871
REMARK 465     SER B  1872
REMARK 465     HIS B  1873
REMARK 465     ASP B  1874
REMARK 465     ASP B  1875
REMARK 465     LEU B  1876
REMARK 465     GLN B  1877
REMARK 465     ALA B  1878
REMARK 465     VAL B  1879
REMARK 465     ALA B  1880
REMARK 465     VAL B  1881
REMARK 465     ALA B  1882
REMARK 465     VAL B  1883
REMARK 465     SER B  1884
REMARK 465     THR B  1885
REMARK 465     LYS B  1886
REMARK 465     LYS B  1887
REMARK 465     SER C    95
REMARK 465     GLU C    96
REMARK 465     LEU C    97
REMARK 465     ALA C    98
REMARK 465     ALA C    99
REMARK 465     LYS C   100
REMARK 465     GLU C   101
REMARK 465     GLU C   102
REMARK 465     PRO C   103
REMARK 465     ALA C   104
REMARK 465     LYS C   105
REMARK 465     GLU C   106
REMARK 465     GLU C   107
REMARK 465     ALA C   108
REMARK 465     PRO C   109
REMARK 465     ALA C   110
REMARK 465     PRO C   111
REMARK 465     THR C   112
REMARK 465     PRO C   113
REMARK 465     ALA C   114
REMARK 465     ALA C   115
REMARK 465     SER C   116
REMARK 465     ALA C   117
REMARK 465     PRO C   118
REMARK 465     ALA C   119
REMARK 465     PRO C   120
REMARK 465     ALA C   121
REMARK 465     ALA C   122
REMARK 465     ALA C   123
REMARK 465     ALA C   124
REMARK 465     PRO C   125
REMARK 465     ALA C   126
REMARK 465     PRO C   127
REMARK 465     VAL C   128
REMARK 465     ALA C   129
REMARK 465     ALA C   130
REMARK 465     ALA C   131
REMARK 465     ALA C   132
REMARK 465     PRO C   133
REMARK 465     ALA C   134
REMARK 465     ALA C   135
REMARK 465     ALA C   136
REMARK 465     ALA C   137
REMARK 465     ALA C   138
REMARK 465     GLU C   139
REMARK 465     SER C   303
REMARK 465     SER C   304
REMARK 465     ALA C   305
REMARK 465     ALA C   306
REMARK 465     SER C   307
REMARK 465     ALA C   308
REMARK 465     SER C   309
REMARK 465     GLY C   310
REMARK 465     ALA C   311
REMARK 465     ALA C   312
REMARK 465     GLY C   313
REMARK 465     ALA C   314
REMARK 465     GLY C   315
REMARK 465     ALA C   316
REMARK 465     ALA C   317
REMARK 465     ALA C   318
REMARK 465     GLY C   319
REMARK 465     ALA C   320
REMARK 465     ALA C   321
REMARK 465     MET C   322
REMARK 465     ILE C   323
REMARK 465     ASP C   324
REMARK 465     ALA C   325
REMARK 465     GLY C   326
REMARK 465     ALA C   327
REMARK 465     PRO C   541
REMARK 465     THR C   542
REMARK 465     ILE C   543
REMARK 465     GLU C   544
REMARK 465     GLU C   545
REMARK 465     ASP C   546
REMARK 465     LEU C   547
REMARK 465     THR C   548
REMARK 465     ARG C   549
REMARK 465     VAL C   550
REMARK 465     TYR C   551
REMARK 465     LYS C   552
REMARK 465     ALA C   553
REMARK 465     ILE C   554
REMARK 465     SER C   555
REMARK 465     ALA C   556
REMARK 465     GLN C   557
REMARK 465     ALA C   558
REMARK 465     ASP C   559
REMARK 465     LYS C   560
REMARK 465     GLN C   561
REMARK 465     ASP C   562
REMARK 465     ILE C   563
REMARK 465     SER C   564
REMARK 465     SER C   565
REMARK 465     SER C   566
REMARK 465     THR C   567
REMARK 465     ARG C   568
REMARK 465     VAL C   569
REMARK 465     GLU C   570
REMARK 465     PHE C   571
REMARK 465     GLU C   572
REMARK 465     LYS C   573
REMARK 465     LEU C   574
REMARK 465     TYR C   575
REMARK 465     SER C   576
REMARK 465     ASP C   577
REMARK 465     LEU C   578
REMARK 465     MET C   579
REMARK 465     LYS C   580
REMARK 465     PHE C   581
REMARK 465     LEU C   582
REMARK 465     GLU C   583
REMARK 465     SER C   584
REMARK 465     SER C   585
REMARK 465     LYS C   586
REMARK 465     GLU C   587
REMARK 465     ILE C   588
REMARK 465     ASP C   589
REMARK 465     PRO C   590
REMARK 465     SER C   591
REMARK 465     GLN C   592
REMARK 465     THR C   593
REMARK 465     THR C   594
REMARK 465     GLN C   595
REMARK 465     LEU C   596
REMARK 465     ALA C   597
REMARK 465     GLY C   598
REMARK 465     GLY C   876
REMARK 465     LEU C   877
REMARK 465     MET C   878
REMARK 465     SER C   879
REMARK 465     ALA C   880
REMARK 465     ASN C  1748
REMARK 465     THR C  1749
REMARK 465     ILE C  1750
REMARK 465     GLU C  1751
REMARK 465     THR C  1752
REMARK 465     ALA C  1753
REMARK 465     LYS C  1754
REMARK 465     MET C  1755
REMARK 465     ILE C  1756
REMARK 465     GLU C  1757
REMARK 465     ASN C  1758
REMARK 465     MET C  1759
REMARK 465     THR C  1760
REMARK 465     LYS C  1761
REMARK 465     GLU C  1762
REMARK 465     LYS C  1763
REMARK 465     VAL C  1764
REMARK 465     SER C  1765
REMARK 465     ASN C  1766
REMARK 465     GLY C  1767
REMARK 465     GLY C  1768
REMARK 465     VAL C  1769
REMARK 465     GLY C  1770
REMARK 465     VAL C  1771
REMARK 465     ASP C  1772
REMARK 465     VAL C  1773
REMARK 465     GLU C  1774
REMARK 465     LEU C  1775
REMARK 465     ILE C  1776
REMARK 465     THR C  1777
REMARK 465     SER C  1778
REMARK 465     ILE C  1779
REMARK 465     ASN C  1780
REMARK 465     VAL C  1781
REMARK 465     GLU C  1782
REMARK 465     ASN C  1783
REMARK 465     ASP C  1784
REMARK 465     THR C  1785
REMARK 465     PHE C  1786
REMARK 465     ILE C  1787
REMARK 465     GLU C  1788
REMARK 465     ARG C  1789
REMARK 465     ASN C  1790
REMARK 465     PHE C  1791
REMARK 465     THR C  1792
REMARK 465     PRO C  1793
REMARK 465     GLN C  1794
REMARK 465     GLU C  1795
REMARK 465     ILE C  1796
REMARK 465     GLU C  1797
REMARK 465     TYR C  1798
REMARK 465     CYS C  1799
REMARK 465     SER C  1800
REMARK 465     ALA C  1801
REMARK 465     GLN C  1802
REMARK 465     PRO C  1803
REMARK 465     SER C  1804
REMARK 465     VAL C  1805
REMARK 465     GLN C  1806
REMARK 465     SER C  1807
REMARK 465     SER C  1808
REMARK 465     PHE C  1809
REMARK 465     ALA C  1810
REMARK 465     GLY C  1811
REMARK 465     THR C  1812
REMARK 465     TRP C  1813
REMARK 465     SER C  1814
REMARK 465     ALA C  1815
REMARK 465     LYS C  1816
REMARK 465     GLU C  1817
REMARK 465     ALA C  1818
REMARK 465     VAL C  1819
REMARK 465     PHE C  1820
REMARK 465     LYS C  1821
REMARK 465     SER C  1822
REMARK 465     LEU C  1823
REMARK 465     GLY C  1824
REMARK 465     VAL C  1825
REMARK 465     LYS C  1826
REMARK 465     SER C  1827
REMARK 465     LEU C  1828
REMARK 465     GLY C  1829
REMARK 465     GLY C  1830
REMARK 465     GLY C  1831
REMARK 465     ALA C  1832
REMARK 465     ALA C  1833
REMARK 465     LEU C  1834
REMARK 465     LYS C  1835
REMARK 465     ASP C  1836
REMARK 465     ILE C  1837
REMARK 465     GLU C  1838
REMARK 465     ILE C  1839
REMARK 465     VAL C  1840
REMARK 465     ARG C  1841
REMARK 465     VAL C  1842
REMARK 465     ASN C  1843
REMARK 465     LYS C  1844
REMARK 465     ASN C  1845
REMARK 465     ALA C  1846
REMARK 465     PRO C  1847
REMARK 465     ALA C  1848
REMARK 465     VAL C  1849
REMARK 465     GLU C  1850
REMARK 465     LEU C  1851
REMARK 465     HIS C  1852
REMARK 465     GLY C  1853
REMARK 465     ASN C  1854
REMARK 465     ALA C  1855
REMARK 465     LYS C  1856
REMARK 465     LYS C  1857
REMARK 465     ALA C  1858
REMARK 465     ALA C  1859
REMARK 465     GLU C  1860
REMARK 465     GLU C  1861
REMARK 465     ALA C  1862
REMARK 465     GLY C  1863
REMARK 465     VAL C  1864
REMARK 465     THR C  1865
REMARK 465     ASP C  1866
REMARK 465     VAL C  1867
REMARK 465     LYS C  1868
REMARK 465     VAL C  1869
REMARK 465     SER C  1870
REMARK 465     ILE C  1871
REMARK 465     SER C  1872
REMARK 465     HIS C  1873
REMARK 465     ASP C  1874
REMARK 465     ASP C  1875
REMARK 465     LEU C  1876
REMARK 465     GLN C  1877
REMARK 465     ALA C  1878
REMARK 465     VAL C  1879
REMARK 465     ALA C  1880
REMARK 465     VAL C  1881
REMARK 465     ALA C  1882
REMARK 465     VAL C  1883
REMARK 465     SER C  1884
REMARK 465     THR C  1885
REMARK 465     LYS C  1886
REMARK 465     LYS C  1887
REMARK 465     MET G     1
REMARK 465     ASP G     2
REMARK 465     ALA G     3
REMARK 465     TYR G     4
REMARK 465     ASP G  1110
REMARK 465     VAL G  1111
REMARK 465     GLN G  1112
REMARK 465     SER G  1113
REMARK 465     GLN G  1114
REMARK 465     VAL G  1115
REMARK 465     ASP G  1116
REMARK 465     SER G  1117
REMARK 465     SER G  1118
REMARK 465     SER G  1119
REMARK 465     VAL G  1120
REMARK 465     SER G  1121
REMARK 465     GLU G  1122
REMARK 465     SER G  2051
REMARK 465     MET H     1
REMARK 465     ASP H     2
REMARK 465     ALA H     3
REMARK 465     TYR H     4
REMARK 465     ASP H  1110
REMARK 465     VAL H  1111
REMARK 465     GLN H  1112
REMARK 465     SER H  1113
REMARK 465     GLN H  1114
REMARK 465     VAL H  1115
REMARK 465     ASP H  1116
REMARK 465     SER H  1117
REMARK 465     SER H  1118
REMARK 465     SER H  1119
REMARK 465     VAL H  1120
REMARK 465     SER H  1121
REMARK 465     GLU H  1122
REMARK 465     SER H  2051
REMARK 465     MET I     1
REMARK 465     ASP I     2
REMARK 465     ALA I     3
REMARK 465     TYR I     4
REMARK 465     ASP I  1110
REMARK 465     VAL I  1111
REMARK 465     GLN I  1112
REMARK 465     SER I  1113
REMARK 465     GLN I  1114
REMARK 465     VAL I  1115
REMARK 465     ASP I  1116
REMARK 465     SER I  1117
REMARK 465     SER I  1118
REMARK 465     SER I  1119
REMARK 465     VAL I  1120
REMARK 465     SER I  1121
REMARK 465     GLU I  1122
REMARK 465     SER I  2051
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    MET A 599   N   -  CA  -  C   ANGL. DEV. = -18.7 DEGREES
REMARK 500    PRO A 770   C   -  N   -  CA  ANGL. DEV. =   9.3 DEGREES
REMARK 500    MET B 599   N   -  CA  -  C   ANGL. DEV. = -18.6 DEGREES
REMARK 500    MET C 599   N   -  CA  -  C   ANGL. DEV. = -18.6 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ALA A  23      -60.93    -98.86
REMARK 500    SER A  24      152.79    -46.82
REMARK 500    PRO A  51       39.32    -88.32
REMARK 500    LYS A  64      -30.88   -141.19
REMARK 500    ASP A  84       53.05   -115.13
REMARK 500    SER A 162      156.81    -47.81
REMARK 500    LYS A 170     -177.54    -63.73
REMARK 500    SER A 393      -33.09   -132.53
REMARK 500    ASN A 441        1.05    -66.54
REMARK 500    ASP A 504      171.29    -39.83
REMARK 500    ARG A 520      -40.49   -133.29
REMARK 500    LYS A 537      -91.82    -96.11
REMARK 500    GLU A 538     -176.27    -49.84
REMARK 500    GLU A 602      120.29    -27.13
REMARK 500    ALA A 604       24.95    -79.03
REMARK 500    LEU A 605      -87.66    -56.20
REMARK 500    ASP A 785     -143.32   -146.57
REMARK 500    LEU A 796      -66.62   -141.66
REMARK 500    GLU A 856     -146.39   -100.94
REMARK 500    SER A 857       35.13   -141.43
REMARK 500    LYS A 890        2.67    -65.73
REMARK 500    SER A 920      141.27   -172.75
REMARK 500    PRO A 921      136.78    -36.01
REMARK 500    ASN A 987       72.84   -119.65
REMARK 500    PHE A1111       40.03   -140.38
REMARK 500    ASP A1130      115.66    -24.08
REMARK 500    LEU A1291      -53.07   -123.60
REMARK 500    ALA A1304     -126.52     56.17
REMARK 500    CYS A1305        5.68    -68.46
REMARK 500    ALA A1306       21.54   -141.38
REMARK 500    ALA A1363        0.74    -66.41
REMARK 500    MET A1406      147.47   -178.37
REMARK 500    ASP A1412      -95.72    -95.35
REMARK 500    ARG A1416       -0.71   -147.35
REMARK 500    VAL A1436       42.94   -144.31
REMARK 500    GLU A1476      -25.28   -140.74
REMARK 500    ASP A1481       47.12    -87.48
REMARK 500    SER A1545       16.76     91.36
REMARK 500    ASN A1608       85.22    -59.13
REMARK 500    ALA B  23      -62.56   -100.05
REMARK 500    SER B  24      153.17    -46.26
REMARK 500    PRO B  51       39.88    -88.42
REMARK 500    LYS B  64      -31.07   -141.09
REMARK 500    ASP B  84       56.79   -114.16
REMARK 500    SER B 162      156.05    -48.30
REMARK 500    LYS B 170     -177.29    -63.18
REMARK 500    PRO B 198      170.42    -59.18
REMARK 500    SER B 393      -35.28   -131.98
REMARK 500    LEU B 414        4.36    -69.32
REMARK 500    ASN B 441        0.60    -66.92
REMARK 500    ASP B 504      172.45    -40.27
REMARK 500    ARG B 520      -41.32   -132.51
REMARK 500    LYS B 537      -90.52    -96.44
REMARK 500    GLU B 538     -175.87    -51.43
REMARK 500    GLU B 602      122.15    -26.68
REMARK 500    LEU B 605      -88.86    -56.64
REMARK 500    ARG B 709       72.58   -100.91
REMARK 500    ASP B 785     -144.91   -148.89
REMARK 500    LEU B 796      -67.71   -143.69
REMARK 500    GLU B 856     -146.95    -98.13
REMARK 500    SER B 857       35.17   -141.27
REMARK 500    LYS B 890        1.79    -65.18
REMARK 500    SER B 920      141.04   -173.12
REMARK 500    PRO B 921      135.97    -37.28
REMARK 500    PHE B1111       40.40   -140.32
REMARK 500    ASP B1130      115.35    -25.95
REMARK 500    ASN B1194      111.75   -160.97
REMARK 500    VAL B1240      -35.46    -39.00
REMARK 500    LEU B1291      -52.98   -125.35
REMARK 500    ALA B1304     -128.16     54.83
REMARK 500    CYS B1305        6.81    -68.99
REMARK 500    ALA B1363        1.68    -63.64
REMARK 500    MET B1406      148.43    179.79
REMARK 500    ASP B1412      -96.88    -95.93
REMARK 500    ARG B1416       -1.47   -145.85
REMARK 500    VAL B1436       42.35   -143.28
REMARK 500    GLU B1475        2.52    -69.97
REMARK 500    GLU B1476      -25.15   -142.09
REMARK 500    ASP B1481       48.26    -87.76
REMARK 500    SER B1545       17.90     92.53
REMARK 500    ASN B1608       86.97    -60.57
REMARK 500    LEU B1618        0.44    -61.16
REMARK 500    SER C  24      152.31    -47.91
REMARK 500    PRO C  51       40.79    -88.12
REMARK 500    LYS C  64      -30.59   -142.72
REMARK 500    ASP C  84       54.86   -115.12
REMARK 500    SER C 162      156.21    -48.00
REMARK 500    LYS C 170     -176.85    -63.29
REMARK 500    PRO C 198      170.11    -58.77
REMARK 500    SER C 393      -33.42   -132.75
REMARK 500    ASN C 441        2.94    -64.11
REMARK 500    ARG C 442       34.77   -141.68
REMARK 500    ASP C 504      170.84    -39.01
REMARK 500    ARG C 520      -40.68   -133.39
REMARK 500    LYS C 537      -90.63    -95.75
REMARK 500    GLU C 538     -176.07    -51.44
REMARK 500    GLU C 602      122.20    -24.98
REMARK 500    ALA C 604       27.25    -79.47
REMARK 500    LEU C 605      -89.02    -57.61
REMARK 500    ASP C 785     -142.58   -147.56
REMARK 500    LEU C 796      -68.12   -141.43
REMARK 500    GLU C 856     -146.34    -98.29
REMARK 500    SER C 857       35.08   -142.51
REMARK 500    LYS C 890        2.59    -65.05
REMARK 500    SER C 920      140.10   -172.93
REMARK 500    PRO C 921      137.16    -34.35
REMARK 500    ASP C1130      115.52    -26.82
REMARK 500    ASN C1194      112.36   -161.29
REMARK 500    VAL C1240      -36.02    -35.66
REMARK 500    LEU C1291      -52.54   -124.44
REMARK 500    ALA C1304     -128.18     54.18
REMARK 500    CYS C1305        6.86    -68.43
REMARK 500    ALA C1306       20.91   -141.97
REMARK 500    ALA C1363        0.62    -64.46
REMARK 500    MET C1406      147.77   -178.81
REMARK 500    ASP C1412      -94.64    -95.68
REMARK 500    ARG C1416       -0.72   -146.76
REMARK 500    VAL C1436       43.11   -144.59
REMARK 500    GLU C1476      -24.56   -141.09
REMARK 500    ASP C1481       47.00    -87.48
REMARK 500    SER C1545       17.96     90.46
REMARK 500    ASN C1608       84.21    -61.30
REMARK 500    LEU C1618       -1.94    -57.95
REMARK 500    GLN C1739       30.92     78.54
REMARK 500    THR G  24      -73.74    -67.67
REMARK 500    ALA G  25       61.06    -65.66
REMARK 500    SER G  26      -46.26   -165.52
REMARK 500    PHE G  28      -70.91    -64.11
REMARK 500    THR G  45      116.55   -163.71
REMARK 500    GLN G 110      -70.90    -51.58
REMARK 500    GLU G 111      -71.94    -67.39
REMARK 500    ASN G 112     -151.48    -71.10
REMARK 500    LYS G 134       50.94     37.17
REMARK 500    PRO G 136     -179.00    -54.97
REMARK 500    LYS G 139      112.58   -166.37
REMARK 500    ASN G 142       48.22    -86.74
REMARK 500    ASP G 168       72.24   -102.30
REMARK 500    THR G 179      -72.06    -65.85
REMARK 500    THR G 201      -39.12    -36.42
REMARK 500    LEU G 203      -83.59    -57.61
REMARK 500    SER G 274     -121.04     49.94
REMARK 500    ASP G 287      -86.70   -124.50
REMARK 500    PRO G 335      122.57    -30.06
REMARK 500    VAL G 371       72.03   -101.07
REMARK 500    ALA G 374      -75.93    -54.29
REMARK 500    LYS G 397     -152.79    -93.09
REMARK 500    PRO G 422       69.50    -68.60
REMARK 500    THR G 494       46.76   -108.74
REMARK 500    PHE G 496      161.88    -48.94
REMARK 500    LYS G 544      -34.31    -37.02
REMARK 500    PRO G 591       48.54    -72.54
REMARK 500    THR G 598      -74.74    -61.11
REMARK 500    VAL G 654        5.25    -67.06
REMARK 500    PHE G 678      147.53   -175.12
REMARK 500    PRO G 686      159.99    -48.75
REMARK 500    HIS G 740      155.59    -43.05
REMARK 500    HIS G 741     -151.19   -127.41
REMARK 500    SER G 742      143.62    170.60
REMARK 500    ALA G 823       -5.67    -54.54
REMARK 500    LYS G 831       36.93   -140.97
REMARK 500    LYS G 837      -73.40   -119.84
REMARK 500    THR G 871      -61.00   -107.43
REMARK 500    ALA G 905       46.11    -74.81
REMARK 500    ASN G 936       57.45     32.56
REMARK 500    ILE G 967       73.76   -111.96
REMARK 500    LYS G 975       79.17   -113.01
REMARK 500    PRO G1016       35.67    -82.13
REMARK 500    ASP G1022     -154.41   -150.54
REMARK 500    ASP G1032       70.70     33.36
REMARK 500    HIS G1039       53.11   -146.79
REMARK 500    VAL G1044      -61.09    -24.95
REMARK 500    ASP G1045       46.91   -141.95
REMARK 500    LYS G1064      -53.21   -137.78
REMARK 500    ASP G1067       27.35     49.07
REMARK 500    ASP G1092        4.65     52.49
REMARK 500    GLU G1101      -76.86    -38.64
REMARK 500    SER G1124      118.72   -173.61
REMARK 500    LYS G1163      -18.26     75.02
REMARK 500    PRO G1176      167.43    -47.54
REMARK 500    SER G1177      137.18    160.04
REMARK 500    THR G1228     -166.92   -121.65
REMARK 500    PHE G1275       90.11    -66.60
REMARK 500    LEU G1277       41.03    -92.17
REMARK 500    ASN G1307       36.79    -91.58
REMARK 500    ASP G1316       43.54     74.84
REMARK 500    PRO G1340      160.09    -42.87
REMARK 500    ASP G1418        7.61    -48.27
REMARK 500    ILE G1435       97.34    -69.13
REMARK 500    ALA G1510       39.71     34.18
REMARK 500    ASN G1713      103.67    -46.91
REMARK 500    SER G1808     -100.57     60.87
REMARK 500    PRO G1843      131.78    -34.46
REMARK 500    ASP G1845     -169.74    -76.76
REMARK 500    TRP G1884     -154.22    -92.24
REMARK 500    GLN G1896      -55.92   -138.79
REMARK 500    ASP G1923       99.36    -69.29
REMARK 500    PRO G1955      176.91    -40.37
REMARK 500    ARG G1956      -75.76    -53.23
REMARK 500    LEU G1958      132.49    -33.94
REMARK 500    PRO G1975       44.18    -81.11
REMARK 500    PRO G2012     -168.67    -65.90
REMARK 500    LEU G2014      -71.12    -56.21
REMARK 500    PRO G2018      127.82    -38.18
REMARK 500    GLU G2046       22.09    -77.32
REMARK 500    LYS G2047        8.55    -66.47
REMARK 500    THR H  24      -71.90    -68.63
REMARK 500    ALA H  25       61.20    -67.12
REMARK 500    SER H  26      -46.64   -166.22
REMARK 500    PHE H  28      -72.12    -63.30
REMARK 500    THR H  45      117.51   -162.70
REMARK 500    GLU H 111      -70.78    -68.71
REMARK 500    ASN H 112     -151.14    -72.17
REMARK 500    ALA H 133       30.64    -93.33
REMARK 500    LYS H 134       50.01     36.94
REMARK 500    PRO H 136     -178.19    -55.09
REMARK 500    LYS H 139      110.23   -170.81
REMARK 500    ASN H 142       48.60    -86.28
REMARK 500    ASP H 168       71.82   -102.41
REMARK 500    THR H 179      -72.00    -68.93
REMARK 500    THR H 201      -38.38    -36.24
REMARK 500    LEU H 203      -84.52    -55.12
REMARK 500    SER H 274     -119.00     50.97
REMARK 500    ASP H 287      -86.41   -124.72
REMARK 500    SER H 318      127.92    -39.08
REMARK 500    ASN H 331       13.88     59.43
REMARK 500    PRO H 335      123.62    -30.13
REMARK 500    THR H 345      150.58    -44.44
REMARK 500    VAL H 371       71.46   -102.31
REMARK 500    ALA H 374      -76.19    -54.54
REMARK 500    LYS H 397     -152.15    -94.10
REMARK 500    ASP H 403       70.81     52.77
REMARK 500    PRO H 422       70.08    -67.98
REMARK 500    THR H 494       46.48   -108.69
REMARK 500    LYS H 544      -34.87    -38.39
REMARK 500    PRO H 591       49.73    -72.29
REMARK 500    THR H 598      -75.35    -59.76
REMARK 500    VAL H 654        4.40    -66.58
REMARK 500    PHE H 678      146.85   -173.51
REMARK 500    HIS H 740      155.24    -43.65
REMARK 500    HIS H 741     -151.90   -125.62
REMARK 500    SER H 742      143.22    170.26
REMARK 500    ALA H 823       -4.95    -51.83
REMARK 500    LYS H 831       38.43   -141.30
REMARK 500    LYS H 837      -73.04   -120.99
REMARK 500    THR H 871      -60.58   -106.73
REMARK 500    ALA H 905       47.45    -76.47
REMARK 500    ASN H 936       59.85     31.32
REMARK 500    ILE H 967       74.28   -113.61
REMARK 500    LYS H 975       76.92   -112.79
REMARK 500    PRO H1016       34.49    -80.79
REMARK 500    ASP H1022     -155.86   -152.52
REMARK 500    ASP H1032       71.88     35.49
REMARK 500    HIS H1039       53.14   -149.46
REMARK 500    VAL H1044      -59.16    -25.18
REMARK 500    ASP H1045       46.71   -143.47
REMARK 500    LYS H1064      -52.71   -137.56
REMARK 500    ASP H1067       27.71     49.83
REMARK 500    ASP H1092        3.57     53.50
REMARK 500    GLU H1101      -77.42    -40.50
REMARK 500    SER H1124      120.02   -173.11
REMARK 500    LYS H1163      -21.10     77.88
REMARK 500    PRO H1176      168.06    -48.82
REMARK 500    SER H1177      138.07    160.46
REMARK 500    THR H1228     -167.72   -122.72
REMARK 500    PHE H1275       89.81    -66.20
REMARK 500    LEU H1277       40.32    -92.26
REMARK 500    ASN H1307       37.71    -90.64
REMARK 500    ASP H1316       42.91     73.75
REMARK 500    PRO H1340      158.37    -43.83
REMARK 500    ASP H1418        6.24    -46.92
REMARK 500    PHE H1419      -35.79    -39.48
REMARK 500    ILE H1435       96.49    -68.80
REMARK 500    ALA H1510       41.06     33.28
REMARK 500    ASN H1574       52.34     70.20
REMARK 500    ASN H1713      103.77    -46.59
REMARK 500    THR H1740       86.51   -150.05
REMARK 500    SER H1808     -101.36     60.09
REMARK 500    PRO H1843      131.94    -36.99
REMARK 500    TRP H1884     -155.78    -91.14
REMARK 500    GLN H1896      -55.59   -136.36
REMARK 500    ASP H1923       99.18    -69.85
REMARK 500    PRO H1955      178.19    -40.69
REMARK 500    ARG H1956      -74.82    -55.20
REMARK 500    LEU H1958      134.26    -35.64
REMARK 500    PRO H1975       47.20    -83.22
REMARK 500    PRO H2012     -169.36    -63.27
REMARK 500    PRO H2018      126.59    -38.53
REMARK 500    GLU H2046       22.45    -77.49
REMARK 500    LYS H2047        7.99    -65.76
REMARK 500    THR I  24      -72.76    -68.68
REMARK 500    ALA I  25       60.75    -66.88
REMARK 500    SER I  26      -45.82   -165.29
REMARK 500    PHE I  28      -71.10    -64.60
REMARK 500    THR I  45      117.24   -163.25
REMARK 500    ASN I 112     -152.31    -72.93
REMARK 500    ALA I 133       30.32    -92.73
REMARK 500    LYS I 134       50.47     36.95
REMARK 500    PRO I 136     -178.36    -54.36
REMARK 500    LYS I 139      111.67   -172.87
REMARK 500    ASN I 142       49.26    -85.53
REMARK 500    ASP I 168       71.50   -103.39
REMARK 500    THR I 201      -38.52    -37.05
REMARK 500    LEU I 203      -84.55    -54.33
REMARK 500    SER I 274     -119.19     49.08
REMARK 500    ASP I 287      -85.78   -123.68
REMARK 500    ASN I 331       13.04     59.28
REMARK 500    PRO I 335      123.21    -31.56
REMARK 500    ALA I 374      -77.32    -54.31
REMARK 500    LYS I 397     -153.17    -95.97
REMARK 500    ASP I 403       70.37     52.71
REMARK 500    PRO I 422       70.86    -66.51
REMARK 500    PHE I 496      161.28    -47.10
REMARK 500    LYS I 544      -35.72    -35.68
REMARK 500    PRO I 591       49.34    -75.01
REMARK 500    THR I 598      -73.36    -60.94
REMARK 500    VAL I 654        3.11    -62.13
REMARK 500    PHE I 678      147.77   -173.18
REMARK 500    HIS I 740      156.12    -43.46
REMARK 500    HIS I 741     -151.55   -126.61
REMARK 500    SER I 742      144.52    171.68
REMARK 500    ALA I 808      147.42    -39.67
REMARK 500    ALA I 823       -5.88    -52.53
REMARK 500    LYS I 831       35.53   -141.42
REMARK 500    LYS I 837      -73.38   -119.53
REMARK 500    THR I 871      -60.15   -108.09
REMARK 500    ALA I 905       45.79    -76.73
REMARK 500    ASN I 936       59.98     31.92
REMARK 500    ILE I 967       75.28   -112.69
REMARK 500    LYS I 975       78.47   -112.97
REMARK 500    PRO I1014      121.50    -39.58
REMARK 500    PRO I1016       32.56    -82.17
REMARK 500    ASP I1022     -153.85   -150.46
REMARK 500    ASP I1032       72.20     33.17
REMARK 500    HIS I1039       53.59   -147.23
REMARK 500    VAL I1044      -62.64    -24.60
REMARK 500    ASP I1045       48.34   -140.56
REMARK 500    LYS I1064      -51.49   -137.41
REMARK 500    ASP I1067       26.73     48.77
REMARK 500    ASP I1092        5.84     50.39
REMARK 500    GLU I1101      -78.86    -38.56
REMARK 500    SER I1124      119.76   -173.68
REMARK 500    LYS I1163      -18.93     76.94
REMARK 500    PRO I1176      167.08    -48.01
REMARK 500    SER I1177      136.94    161.60
REMARK 500    THR I1228     -167.04   -123.69
REMARK 500    ASP I1257       19.87     58.35
REMARK 500    PHE I1275       88.89    -64.94
REMARK 500    LEU I1277       40.56    -91.82
REMARK 500    ASN I1307       38.23    -90.12
REMARK 500    ASP I1316       42.65     74.68
REMARK 500    PRO I1340      157.09    -42.35
REMARK 500    ASP I1418        7.83    -46.54
REMARK 500    ILE I1435       95.66    -66.33
REMARK 500    ALA I1510       40.80     33.89
REMARK 500    ASN I1574       50.75     71.22
REMARK 500    ASN I1713      103.97    -45.92
REMARK 500    SER I1808     -101.03     59.30
REMARK 500    PRO I1843      132.29    -36.37
REMARK 500    ASP I1845     -168.93    -76.62
REMARK 500    TRP I1884     -155.98    -92.53
REMARK 500    ASN I1895       13.70     59.70
REMARK 500    GLN I1896      -55.33   -137.71
REMARK 500    ASP I1923       99.54    -68.93
REMARK 500    PRO I1955      177.64    -39.79
REMARK 500    ARG I1956      -75.47    -54.04
REMARK 500    LEU I1958      133.74    -34.50
REMARK 500    PRO I1975       43.86    -80.47
REMARK 500    PRO I2012     -168.84    -67.10
REMARK 500    PRO I2018      127.58    -39.43
REMARK 500    GLU I2046       21.44    -76.56
REMARK 500    LYS I2047        8.47    -65.77
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 PRO G 1108     VAL G 1109                  147.30
REMARK 500 PRO H 1108     VAL H 1109                  148.12
REMARK 500 PRO I 1108     VAL I 1109                  148.10
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CHIRAL CENTERS
REMARK 500
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)
REMARK 500
REMARK 500  M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS
REMARK 500    LEU B 605        24.4      L          L   OUTSIDE RANGE
REMARK 500    LEU C 605        24.9      L          L   OUTSIDE RANGE
REMARK 500
REMARK 500 REMARK: NULL
REMARK 610
REMARK 610 MISSING HETEROATOM
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 610 I=INSERTION CODE):
REMARK 610   M RES C SSEQI
REMARK 610     GVL A  180
REMARK 610     GVL B  180
REMARK 610     GVL C  180
REMARK 650
REMARK 650 HELIX
REMARK 650 DETERMINATION METHOD: AUTHOR PROVIDED.
REMARK 700
REMARK 700 SHEET
REMARK 700 DETERMINATION METHOD: AUTHOR PROVIDED.
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FMN G3051
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FMN H3051
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FMN I3051
DBREF  2UV8 A    1  1887  UNP    P19097   FAS2_YEAST       1   1887
DBREF  2UV8 B    1  1887  UNP    P19097   FAS2_YEAST       1   1887
DBREF  2UV8 C    1  1887  UNP    P19097   FAS2_YEAST       1   1887
DBREF  2UV8 G    1  2051  UNP    P07149   FAS1_YEAST       1   2051
DBREF  2UV8 H    1  2051  UNP    P07149   FAS1_YEAST       1   2051
DBREF  2UV8 I    1  2051  UNP    P07149   FAS1_YEAST       1   2051
SEQRES   1 A 1887  MET LYS PRO GLU VAL GLU GLN GLU LEU ALA HIS ILE LEU
SEQRES   2 A 1887  LEU THR GLU LEU LEU ALA TYR GLN PHE ALA SER PRO VAL
SEQRES   3 A 1887  ARG TRP ILE GLU THR GLN ASP VAL PHE LEU LYS ASP PHE
SEQRES   4 A 1887  ASN THR GLU ARG VAL VAL GLU ILE GLY PRO SER PRO THR
SEQRES   5 A 1887  LEU ALA GLY MET ALA GLN ARG THR LEU LYS ASN LYS TYR
SEQRES   6 A 1887  GLU SER TYR ASP ALA ALA LEU SER LEU HIS ARG GLU ILE
SEQRES   7 A 1887  LEU CYS TYR SER LYS ASP ALA LYS GLU ILE TYR TYR THR
SEQRES   8 A 1887  PRO ASP PRO SER GLU LEU ALA ALA LYS GLU GLU PRO ALA
SEQRES   9 A 1887  LYS GLU GLU ALA PRO ALA PRO THR PRO ALA ALA SER ALA
SEQRES  10 A 1887  PRO ALA PRO ALA ALA ALA ALA PRO ALA PRO VAL ALA ALA
SEQRES  11 A 1887  ALA ALA PRO ALA ALA ALA ALA ALA GLU ILE ALA ASP GLU
SEQRES  12 A 1887  PRO VAL LYS ALA SER LEU LEU LEU HIS VAL LEU VAL ALA
SEQRES  13 A 1887  HIS LYS LEU LYS LYS SER LEU ASP SER ILE PRO MET SER
SEQRES  14 A 1887  LYS THR ILE LYS ASP LEU VAL GLY GLY LYS GVL THR VAL
SEQRES  15 A 1887  GLN ASN GLU ILE LEU GLY ASP LEU GLY LYS GLU PHE GLY
SEQRES  16 A 1887  THR THR PRO GLU LYS PRO GLU GLU THR PRO LEU GLU GLU
SEQRES  17 A 1887  LEU ALA GLU THR PHE GLN ASP THR PHE SER GLY ALA LEU
SEQRES  18 A 1887  GLY LYS GLN SER SER SER LEU LEU SER ARG LEU ILE SER
SEQRES  19 A 1887  SER LYS MET PRO GLY GLY PHE THR ILE THR VAL ALA ARG
SEQRES  20 A 1887  LYS TYR LEU GLN THR ARG TRP GLY LEU PRO SER GLY ARG
SEQRES  21 A 1887  GLN ASP GLY VAL LEU LEU VAL ALA LEU SER ASN GLU PRO
SEQRES  22 A 1887  ALA ALA ARG LEU GLY SER GLU ALA ASP ALA LYS ALA PHE
SEQRES  23 A 1887  LEU ASP SER MET ALA GLN LYS TYR ALA SER ILE VAL GLY
SEQRES  24 A 1887  VAL ASP LEU SER SER ALA ALA SER ALA SER GLY ALA ALA
SEQRES  25 A 1887  GLY ALA GLY ALA ALA ALA GLY ALA ALA MET ILE ASP ALA
SEQRES  26 A 1887  GLY ALA LEU GLU GLU ILE THR LYS ASP HIS LYS VAL LEU
SEQRES  27 A 1887  ALA ARG GLN GLN LEU GLN VAL LEU ALA ARG TYR LEU LYS
SEQRES  28 A 1887  MET ASP LEU ASP ASN GLY GLU ARG LYS PHE LEU LYS GLU
SEQRES  29 A 1887  LYS ASP THR VAL ALA GLU LEU GLN ALA GLN LEU ASP TYR
SEQRES  30 A 1887  LEU ASN ALA GLU LEU GLY GLU PHE PHE VAL ASN GLY VAL
SEQRES  31 A 1887  ALA THR SER PHE SER ARG LYS LYS ALA ARG THR PHE ASP
SEQRES  32 A 1887  SER SER TRP ASN TRP ALA LYS GLN SER LEU LEU SER LEU
SEQRES  33 A 1887  TYR PHE GLU ILE ILE HIS GLY VAL LEU LYS ASN VAL ASP
SEQRES  34 A 1887  ARG GLU VAL VAL SER GLU ALA ILE ASN ILE MET ASN ARG
SEQRES  35 A 1887  SER ASN ASP ALA LEU ILE LYS PHE MET GLU TYR HIS ILE
SEQRES  36 A 1887  SER ASN THR ASP GLU THR LYS GLY GLU ASN TYR GLN LEU
SEQRES  37 A 1887  VAL LYS THR LEU GLY GLU GLN LEU ILE GLU ASN CYS LYS
SEQRES  38 A 1887  GLN VAL LEU ASP VAL ASP PRO VAL TYR LYS ASP VAL ALA
SEQRES  39 A 1887  LYS PRO THR GLY PRO LYS THR ALA ILE ASP LYS ASN GLY
SEQRES  40 A 1887  ASN ILE THR TYR SER GLU GLU PRO ARG GLU LYS VAL ARG
SEQRES  41 A 1887  LYS LEU SER GLN TYR VAL GLN GLU MET ALA LEU GLY GLY
SEQRES  42 A 1887  PRO ILE THR LYS GLU SER GLN PRO THR ILE GLU GLU ASP
SEQRES  43 A 1887  LEU THR ARG VAL TYR LYS ALA ILE SER ALA GLN ALA ASP
SEQRES  44 A 1887  LYS GLN ASP ILE SER SER SER THR ARG VAL GLU PHE GLU
SEQRES  45 A 1887  LYS LEU TYR SER ASP LEU MET LYS PHE LEU GLU SER SER
SEQRES  46 A 1887  LYS GLU ILE ASP PRO SER GLN THR THR GLN LEU ALA GLY
SEQRES  47 A 1887  MET ASP VAL GLU ASP ALA LEU ASP LYS ASP SER THR LYS
SEQRES  48 A 1887  GLU VAL ALA SER LEU PRO ASN LYS SER THR ILE SER LYS
SEQRES  49 A 1887  THR VAL SER SER THR ILE PRO ARG GLU THR ILE PRO PHE
SEQRES  50 A 1887  LEU HIS LEU ARG LYS LYS THR PRO ALA GLY ASP TRP LYS
SEQRES  51 A 1887  TYR ASP ARG GLN LEU SER SER LEU PHE LEU ASP GLY LEU
SEQRES  52 A 1887  GLU LYS ALA ALA PHE ASN GLY VAL THR PHE LYS ASP LYS
SEQRES  53 A 1887  TYR VAL LEU ILE THR GLY ALA GLY LYS GLY SER ILE GLY
SEQRES  54 A 1887  ALA GLU VAL LEU GLN GLY LEU LEU GLN GLY GLY ALA LYS
SEQRES  55 A 1887  VAL VAL VAL THR THR SER ARG PHE SER LYS GLN VAL THR
SEQRES  56 A 1887  ASP TYR TYR GLN SER ILE TYR ALA LYS TYR GLY ALA LYS
SEQRES  57 A 1887  GLY SER THR LEU ILE VAL VAL PRO PHE ASN GLN GLY SER
SEQRES  58 A 1887  LYS GLN ASP VAL GLU ALA LEU ILE GLU PHE ILE TYR ASP
SEQRES  59 A 1887  THR GLU LYS ASN GLY GLY LEU GLY TRP ASP LEU ASP ALA
SEQRES  60 A 1887  ILE ILE PRO PHE ALA ALA ILE PRO GLU GLN GLY ILE GLU
SEQRES  61 A 1887  LEU GLU HIS ILE ASP SER LYS SER GLU PHE ALA HIS ARG
SEQRES  62 A 1887  ILE MET LEU THR ASN ILE LEU ARG MET MET GLY CYS VAL
SEQRES  63 A 1887  LYS LYS GLN LYS SER ALA ARG GLY ILE GLU THR ARG PRO
SEQRES  64 A 1887  ALA GLN VAL ILE LEU PRO MET SER PRO ASN HIS GLY THR
SEQRES  65 A 1887  PHE GLY GLY ASP GLY MET TYR SER GLU SER LYS LEU SER
SEQRES  66 A 1887  LEU GLU THR LEU PHE ASN ARG TRP HIS SER GLU SER TRP
SEQRES  67 A 1887  ALA ASN GLN LEU THR VAL CYS GLY ALA ILE ILE GLY TRP
SEQRES  68 A 1887  THR ARG GLY THR GLY LEU MET SER ALA ASN ASN ILE ILE
SEQRES  69 A 1887  ALA GLU GLY ILE GLU LYS MET GLY VAL ARG THR PHE SER
SEQRES  70 A 1887  GLN LYS GLU MET ALA PHE ASN LEU LEU GLY LEU LEU THR
SEQRES  71 A 1887  PRO GLU VAL VAL GLU LEU CYS GLN LYS SER PRO VAL MET
SEQRES  72 A 1887  ALA ASP LEU ASN GLY GLY LEU GLN PHE VAL PRO GLU LEU
SEQRES  73 A 1887  LYS GLU PHE THR ALA LYS LEU ARG LYS GLU LEU VAL GLU
SEQRES  74 A 1887  THR SER GLU VAL ARG LYS ALA VAL SER ILE GLU THR ALA
SEQRES  75 A 1887  LEU GLU HIS LYS VAL VAL ASN GLY ASN SER ALA ASP ALA
SEQRES  76 A 1887  ALA TYR ALA GLN VAL GLU ILE GLN PRO ARG ALA ASN ILE
SEQRES  77 A 1887  GLN LEU ASP PHE PRO GLU LEU LYS PRO TYR LYS GLN VAL
SEQRES  78 A 1887  LYS GLN ILE ALA PRO ALA GLU LEU GLU GLY LEU LEU ASP
SEQRES  79 A 1887  LEU GLU ARG VAL ILE VAL VAL THR GLY PHE ALA GLU VAL
SEQRES  80 A 1887  GLY PRO TRP GLY SER ALA ARG THR ARG TRP GLU MET GLU
SEQRES  81 A 1887  ALA PHE GLY GLU PHE SER LEU GLU GLY CYS VAL GLU MET
SEQRES  82 A 1887  ALA TRP ILE MET GLY PHE ILE SER TYR HIS ASN GLY ASN
SEQRES  83 A 1887  LEU LYS GLY ARG PRO TYR THR GLY TRP VAL ASP SER LYS
SEQRES  84 A 1887  THR LYS GLU PRO VAL ASP ASP LYS ASP VAL LYS ALA LYS
SEQRES  85 A 1887  TYR GLU THR SER ILE LEU GLU HIS SER GLY ILE ARG LEU
SEQRES  86 A 1887  ILE GLU PRO GLU LEU PHE ASN GLY TYR ASN PRO GLU LYS
SEQRES  87 A 1887  LYS GLU MET ILE GLN GLU VAL ILE VAL GLU GLU ASP LEU
SEQRES  88 A 1887  GLU PRO PHE GLU ALA SER LYS GLU THR ALA GLU GLN PHE
SEQRES  89 A 1887  LYS HIS GLN HIS GLY ASP LYS VAL ASP ILE PHE GLU ILE
SEQRES  90 A 1887  PRO GLU THR GLY GLU TYR SER VAL LYS LEU LEU LYS GLY
SEQRES  91 A 1887  ALA THR LEU TYR ILE PRO LYS ALA LEU ARG PHE ASP ARG
SEQRES  92 A 1887  LEU VAL ALA GLY GLN ILE PRO THR GLY TRP ASN ALA LYS
SEQRES  93 A 1887  THR TYR GLY ILE SER ASP ASP ILE ILE SER GLN VAL ASP
SEQRES  94 A 1887  PRO ILE THR LEU PHE VAL LEU VAL SER VAL VAL GLU ALA
SEQRES  95 A 1887  PHE ILE ALA SER GLY ILE THR ASP PRO TYR GLU MET TYR
SEQRES  96 A 1887  LYS TYR VAL HIS VAL SER GLU VAL GLY ASN CYS SER GLY
SEQRES  97 A 1887  SER GLY MET GLY GLY VAL SER ALA LEU ARG GLY MET PHE
SEQRES  98 A 1887  LYS ASP ARG PHE LYS ASP GLU PRO VAL GLN ASN ASP ILE
SEQRES  99 A 1887  LEU GLN GLU SER PHE ILE ASN THR MET SER ALA TRP VAL
SEQRES 100 A 1887  ASN MET LEU LEU ILE SER SER SER GLY PRO ILE LYS THR
SEQRES 101 A 1887  PRO VAL GLY ALA CYS ALA THR SER VAL GLU SER VAL ASP
SEQRES 102 A 1887  ILE GLY VAL GLU THR ILE LEU SER GLY LYS ALA ARG ILE
SEQRES 103 A 1887  CYS ILE VAL GLY GLY TYR ASP ASP PHE GLN GLU GLU GLY
SEQRES 104 A 1887  SER PHE GLU PHE GLY ASN MET LYS ALA THR SER ASN THR
SEQRES 105 A 1887  LEU GLU GLU PHE GLU HIS GLY ARG THR PRO ALA GLU MET
SEQRES 106 A 1887  SER ARG PRO ALA THR THR THR ARG ASN GLY PHE MET GLU
SEQRES 107 A 1887  ALA GLN GLY ALA GLY ILE GLN ILE ILE MET GLN ALA ASP
SEQRES 108 A 1887  LEU ALA LEU LYS MET GLY VAL PRO ILE TYR GLY ILE VAL
SEQRES 109 A 1887  ALA MET ALA ALA THR ALA THR ASP LYS ILE GLY ARG SER
SEQRES 110 A 1887  VAL PRO ALA PRO GLY LYS GLY ILE LEU THR THR ALA ARG
SEQRES 111 A 1887  GLU HIS HIS SER SER VAL LYS TYR ALA SER PRO ASN LEU
SEQRES 112 A 1887  ASN MET LYS TYR ARG LYS ARG GLN LEU VAL THR ARG GLU
SEQRES 113 A 1887  ALA GLN ILE LYS ASP TRP VAL GLU ASN GLU LEU GLU ALA
SEQRES 114 A 1887  LEU LYS LEU GLU ALA GLU GLU ILE PRO SER GLU ASP GLN
SEQRES 115 A 1887  ASN GLU PHE LEU LEU GLU ARG THR ARG GLU ILE HIS ASN
SEQRES 116 A 1887  GLU ALA GLU SER GLN LEU ARG ALA ALA GLN GLN GLN TRP
SEQRES 117 A 1887  GLY ASN ASP PHE TYR LYS ARG ASP PRO ARG ILE ALA PRO
SEQRES 118 A 1887  LEU ARG GLY ALA LEU ALA THR TYR GLY LEU THR ILE ASP
SEQRES 119 A 1887  ASP LEU GLY VAL ALA SER PHE HIS GLY THR SER THR LYS
SEQRES 120 A 1887  ALA ASN ASP LYS ASN GLU SER ALA THR ILE ASN GLU MET
SEQRES 121 A 1887  MET LYS HIS LEU GLY ARG SER GLU GLY ASN PRO VAL ILE
SEQRES 122 A 1887  GLY VAL PHE GLN LYS PHE LEU THR GLY HIS PRO LYS GLY
SEQRES 123 A 1887  ALA ALA GLY ALA TRP MET MET ASN GLY ALA LEU GLN ILE
SEQRES 124 A 1887  LEU ASN SER GLY ILE ILE PRO GLY ASN ARG ASN ALA ASP
SEQRES 125 A 1887  ASN VAL ASP LYS ILE LEU GLU GLN PHE GLU TYR VAL LEU
SEQRES 126 A 1887  TYR PRO SER LYS THR LEU LYS THR ASP GLY VAL ARG ALA
SEQRES 127 A 1887  VAL SER ILE THR SER PHE GLY PHE GLY GLN LYS GLY GLY
SEQRES 128 A 1887  GLN ALA ILE VAL VAL HIS PRO ASP TYR LEU TYR GLY ALA
SEQRES 129 A 1887  ILE THR GLU ASP ARG TYR ASN GLU TYR VAL ALA LYS VAL
SEQRES 130 A 1887  SER ALA ARG GLU LYS SER ALA TYR LYS PHE PHE HIS ASN
SEQRES 131 A 1887  GLY MET ILE TYR ASN LYS LEU PHE VAL SER LYS GLU HIS
SEQRES 132 A 1887  ALA PRO TYR THR ASP GLU LEU GLU GLU ASP VAL TYR LEU
SEQRES 133 A 1887  ASP PRO LEU ALA ARG VAL SER LYS ASP LYS LYS SER GLY
SEQRES 134 A 1887  SER LEU THR PHE ASN SER LYS ASN ILE GLN SER LYS ASP
SEQRES 135 A 1887  SER TYR ILE ASN ALA ASN THR ILE GLU THR ALA LYS MET
SEQRES 136 A 1887  ILE GLU ASN MET THR LYS GLU LYS VAL SER ASN GLY GLY
SEQRES 137 A 1887  VAL GLY VAL ASP VAL GLU LEU ILE THR SER ILE ASN VAL
SEQRES 138 A 1887  GLU ASN ASP THR PHE ILE GLU ARG ASN PHE THR PRO GLN
SEQRES 139 A 1887  GLU ILE GLU TYR CYS SER ALA GLN PRO SER VAL GLN SER
SEQRES 140 A 1887  SER PHE ALA GLY THR TRP SER ALA LYS GLU ALA VAL PHE
SEQRES 141 A 1887  LYS SER LEU GLY VAL LYS SER LEU GLY GLY GLY ALA ALA
SEQRES 142 A 1887  LEU LYS ASP ILE GLU ILE VAL ARG VAL ASN LYS ASN ALA
SEQRES 143 A 1887  PRO ALA VAL GLU LEU HIS GLY ASN ALA LYS LYS ALA ALA
SEQRES 144 A 1887  GLU GLU ALA GLY VAL THR ASP VAL LYS VAL SER ILE SER
SEQRES 145 A 1887  HIS ASP ASP LEU GLN ALA VAL ALA VAL ALA VAL SER THR
SEQRES 146 A 1887  LYS LYS
SEQRES   1 B 1887  MET LYS PRO GLU VAL GLU GLN GLU LEU ALA HIS ILE LEU
SEQRES   2 B 1887  LEU THR GLU LEU LEU ALA TYR GLN PHE ALA SER PRO VAL
SEQRES   3 B 1887  ARG TRP ILE GLU THR GLN ASP VAL PHE LEU LYS ASP PHE
SEQRES   4 B 1887  ASN THR GLU ARG VAL VAL GLU ILE GLY PRO SER PRO THR
SEQRES   5 B 1887  LEU ALA GLY MET ALA GLN ARG THR LEU LYS ASN LYS TYR
SEQRES   6 B 1887  GLU SER TYR ASP ALA ALA LEU SER LEU HIS ARG GLU ILE
SEQRES   7 B 1887  LEU CYS TYR SER LYS ASP ALA LYS GLU ILE TYR TYR THR
SEQRES   8 B 1887  PRO ASP PRO SER GLU LEU ALA ALA LYS GLU GLU PRO ALA
SEQRES   9 B 1887  LYS GLU GLU ALA PRO ALA PRO THR PRO ALA ALA SER ALA
SEQRES  10 B 1887  PRO ALA PRO ALA ALA ALA ALA PRO ALA PRO VAL ALA ALA
SEQRES  11 B 1887  ALA ALA PRO ALA ALA ALA ALA ALA GLU ILE ALA ASP GLU
SEQRES  12 B 1887  PRO VAL LYS ALA SER LEU LEU LEU HIS VAL LEU VAL ALA
SEQRES  13 B 1887  HIS LYS LEU LYS LYS SER LEU ASP SER ILE PRO MET SER
SEQRES  14 B 1887  LYS THR ILE LYS ASP LEU VAL GLY GLY LYS GVL THR VAL
SEQRES  15 B 1887  GLN ASN GLU ILE LEU GLY ASP LEU GLY LYS GLU PHE GLY
SEQRES  16 B 1887  THR THR PRO GLU LYS PRO GLU GLU THR PRO LEU GLU GLU
SEQRES  17 B 1887  LEU ALA GLU THR PHE GLN ASP THR PHE SER GLY ALA LEU
SEQRES  18 B 1887  GLY LYS GLN SER SER SER LEU LEU SER ARG LEU ILE SER
SEQRES  19 B 1887  SER LYS MET PRO GLY GLY PHE THR ILE THR VAL ALA ARG
SEQRES  20 B 1887  LYS TYR LEU GLN THR ARG TRP GLY LEU PRO SER GLY ARG
SEQRES  21 B 1887  GLN ASP GLY VAL LEU LEU VAL ALA LEU SER ASN GLU PRO
SEQRES  22 B 1887  ALA ALA ARG LEU GLY SER GLU ALA ASP ALA LYS ALA PHE
SEQRES  23 B 1887  LEU ASP SER MET ALA GLN LYS TYR ALA SER ILE VAL GLY
SEQRES  24 B 1887  VAL ASP LEU SER SER ALA ALA SER ALA SER GLY ALA ALA
SEQRES  25 B 1887  GLY ALA GLY ALA ALA ALA GLY ALA ALA MET ILE ASP ALA
SEQRES  26 B 1887  GLY ALA LEU GLU GLU ILE THR LYS ASP HIS LYS VAL LEU
SEQRES  27 B 1887  ALA ARG GLN GLN LEU GLN VAL LEU ALA ARG TYR LEU LYS
SEQRES  28 B 1887  MET ASP LEU ASP ASN GLY GLU ARG LYS PHE LEU LYS GLU
SEQRES  29 B 1887  LYS ASP THR VAL ALA GLU LEU GLN ALA GLN LEU ASP TYR
SEQRES  30 B 1887  LEU ASN ALA GLU LEU GLY GLU PHE PHE VAL ASN GLY VAL
SEQRES  31 B 1887  ALA THR SER PHE SER ARG LYS LYS ALA ARG THR PHE ASP
SEQRES  32 B 1887  SER SER TRP ASN TRP ALA LYS GLN SER LEU LEU SER LEU
SEQRES  33 B 1887  TYR PHE GLU ILE ILE HIS GLY VAL LEU LYS ASN VAL ASP
SEQRES  34 B 1887  ARG GLU VAL VAL SER GLU ALA ILE ASN ILE MET ASN ARG
SEQRES  35 B 1887  SER ASN ASP ALA LEU ILE LYS PHE MET GLU TYR HIS ILE
SEQRES  36 B 1887  SER ASN THR ASP GLU THR LYS GLY GLU ASN TYR GLN LEU
SEQRES  37 B 1887  VAL LYS THR LEU GLY GLU GLN LEU ILE GLU ASN CYS LYS
SEQRES  38 B 1887  GLN VAL LEU ASP VAL ASP PRO VAL TYR LYS ASP VAL ALA
SEQRES  39 B 1887  LYS PRO THR GLY PRO LYS THR ALA ILE ASP LYS ASN GLY
SEQRES  40 B 1887  ASN ILE THR TYR SER GLU GLU PRO ARG GLU LYS VAL ARG
SEQRES  41 B 1887  LYS LEU SER GLN TYR VAL GLN GLU MET ALA LEU GLY GLY
SEQRES  42 B 1887  PRO ILE THR LYS GLU SER GLN PRO THR ILE GLU GLU ASP
SEQRES  43 B 1887  LEU THR ARG VAL TYR LYS ALA ILE SER ALA GLN ALA ASP
SEQRES  44 B 1887  LYS GLN ASP ILE SER SER SER THR ARG VAL GLU PHE GLU
SEQRES  45 B 1887  LYS LEU TYR SER ASP LEU MET LYS PHE LEU GLU SER SER
SEQRES  46 B 1887  LYS GLU ILE ASP PRO SER GLN THR THR GLN LEU ALA GLY
SEQRES  47 B 1887  MET ASP VAL GLU ASP ALA LEU ASP LYS ASP SER THR LYS
SEQRES  48 B 1887  GLU VAL ALA SER LEU PRO ASN LYS SER THR ILE SER LYS
SEQRES  49 B 1887  THR VAL SER SER THR ILE PRO ARG GLU THR ILE PRO PHE
SEQRES  50 B 1887  LEU HIS LEU ARG LYS LYS THR PRO ALA GLY ASP TRP LYS
SEQRES  51 B 1887  TYR ASP ARG GLN LEU SER SER LEU PHE LEU ASP GLY LEU
SEQRES  52 B 1887  GLU LYS ALA ALA PHE ASN GLY VAL THR PHE LYS ASP LYS
SEQRES  53 B 1887  TYR VAL LEU ILE THR GLY ALA GLY LYS GLY SER ILE GLY
SEQRES  54 B 1887  ALA GLU VAL LEU GLN GLY LEU LEU GLN GLY GLY ALA LYS
SEQRES  55 B 1887  VAL VAL VAL THR THR SER ARG PHE SER LYS GLN VAL THR
SEQRES  56 B 1887  ASP TYR TYR GLN SER ILE TYR ALA LYS TYR GLY ALA LYS
SEQRES  57 B 1887  GLY SER THR LEU ILE VAL VAL PRO PHE ASN GLN GLY SER
SEQRES  58 B 1887  LYS GLN ASP VAL GLU ALA LEU ILE GLU PHE ILE TYR ASP
SEQRES  59 B 1887  THR GLU LYS ASN GLY GLY LEU GLY TRP ASP LEU ASP ALA
SEQRES  60 B 1887  ILE ILE PRO PHE ALA ALA ILE PRO GLU GLN GLY ILE GLU
SEQRES  61 B 1887  LEU GLU HIS ILE ASP SER LYS SER GLU PHE ALA HIS ARG
SEQRES  62 B 1887  ILE MET LEU THR ASN ILE LEU ARG MET MET GLY CYS VAL
SEQRES  63 B 1887  LYS LYS GLN LYS SER ALA ARG GLY ILE GLU THR ARG PRO
SEQRES  64 B 1887  ALA GLN VAL ILE LEU PRO MET SER PRO ASN HIS GLY THR
SEQRES  65 B 1887  PHE GLY GLY ASP GLY MET TYR SER GLU SER LYS LEU SER
SEQRES  66 B 1887  LEU GLU THR LEU PHE ASN ARG TRP HIS SER GLU SER TRP
SEQRES  67 B 1887  ALA ASN GLN LEU THR VAL CYS GLY ALA ILE ILE GLY TRP
SEQRES  68 B 1887  THR ARG GLY THR GLY LEU MET SER ALA ASN ASN ILE ILE
SEQRES  69 B 1887  ALA GLU GLY ILE GLU LYS MET GLY VAL ARG THR PHE SER
SEQRES  70 B 1887  GLN LYS GLU MET ALA PHE ASN LEU LEU GLY LEU LEU THR
SEQRES  71 B 1887  PRO GLU VAL VAL GLU LEU CYS GLN LYS SER PRO VAL MET
SEQRES  72 B 1887  ALA ASP LEU ASN GLY GLY LEU GLN PHE VAL PRO GLU LEU
SEQRES  73 B 1887  LYS GLU PHE THR ALA LYS LEU ARG LYS GLU LEU VAL GLU
SEQRES  74 B 1887  THR SER GLU VAL ARG LYS ALA VAL SER ILE GLU THR ALA
SEQRES  75 B 1887  LEU GLU HIS LYS VAL VAL ASN GLY ASN SER ALA ASP ALA
SEQRES  76 B 1887  ALA TYR ALA GLN VAL GLU ILE GLN PRO ARG ALA ASN ILE
SEQRES  77 B 1887  GLN LEU ASP PHE PRO GLU LEU LYS PRO TYR LYS GLN VAL
SEQRES  78 B 1887  LYS GLN ILE ALA PRO ALA GLU LEU GLU GLY LEU LEU ASP
SEQRES  79 B 1887  LEU GLU ARG VAL ILE VAL VAL THR GLY PHE ALA GLU VAL
SEQRES  80 B 1887  GLY PRO TRP GLY SER ALA ARG THR ARG TRP GLU MET GLU
SEQRES  81 B 1887  ALA PHE GLY GLU PHE SER LEU GLU GLY CYS VAL GLU MET
SEQRES  82 B 1887  ALA TRP ILE MET GLY PHE ILE SER TYR HIS ASN GLY ASN
SEQRES  83 B 1887  LEU LYS GLY ARG PRO TYR THR GLY TRP VAL ASP SER LYS
SEQRES  84 B 1887  THR LYS GLU PRO VAL ASP ASP LYS ASP VAL LYS ALA LYS
SEQRES  85 B 1887  TYR GLU THR SER ILE LEU GLU HIS SER GLY ILE ARG LEU
SEQRES  86 B 1887  ILE GLU PRO GLU LEU PHE ASN GLY TYR ASN PRO GLU LYS
SEQRES  87 B 1887  LYS GLU MET ILE GLN GLU VAL ILE VAL GLU GLU ASP LEU
SEQRES  88 B 1887  GLU PRO PHE GLU ALA SER LYS GLU THR ALA GLU GLN PHE
SEQRES  89 B 1887  LYS HIS GLN HIS GLY ASP LYS VAL ASP ILE PHE GLU ILE
SEQRES  90 B 1887  PRO GLU THR GLY GLU TYR SER VAL LYS LEU LEU LYS GLY
SEQRES  91 B 1887  ALA THR LEU TYR ILE PRO LYS ALA LEU ARG PHE ASP ARG
SEQRES  92 B 1887  LEU VAL ALA GLY GLN ILE PRO THR GLY TRP ASN ALA LYS
SEQRES  93 B 1887  THR TYR GLY ILE SER ASP ASP ILE ILE SER GLN VAL ASP
SEQRES  94 B 1887  PRO ILE THR LEU PHE VAL LEU VAL SER VAL VAL GLU ALA
SEQRES  95 B 1887  PHE ILE ALA SER GLY ILE THR ASP PRO TYR GLU MET TYR
SEQRES  96 B 1887  LYS TYR VAL HIS VAL SER GLU VAL GLY ASN CYS SER GLY
SEQRES  97 B 1887  SER GLY MET GLY GLY VAL SER ALA LEU ARG GLY MET PHE
SEQRES  98 B 1887  LYS ASP ARG PHE LYS ASP GLU PRO VAL GLN ASN ASP ILE
SEQRES  99 B 1887  LEU GLN GLU SER PHE ILE ASN THR MET SER ALA TRP VAL
SEQRES 100 B 1887  ASN MET LEU LEU ILE SER SER SER GLY PRO ILE LYS THR
SEQRES 101 B 1887  PRO VAL GLY ALA CYS ALA THR SER VAL GLU SER VAL ASP
SEQRES 102 B 1887  ILE GLY VAL GLU THR ILE LEU SER GLY LYS ALA ARG ILE
SEQRES 103 B 1887  CYS ILE VAL GLY GLY TYR ASP ASP PHE GLN GLU GLU GLY
SEQRES 104 B 1887  SER PHE GLU PHE GLY ASN MET LYS ALA THR SER ASN THR
SEQRES 105 B 1887  LEU GLU GLU PHE GLU HIS GLY ARG THR PRO ALA GLU MET
SEQRES 106 B 1887  SER ARG PRO ALA THR THR THR ARG ASN GLY PHE MET GLU
SEQRES 107 B 1887  ALA GLN GLY ALA GLY ILE GLN ILE ILE MET GLN ALA ASP
SEQRES 108 B 1887  LEU ALA LEU LYS MET GLY VAL PRO ILE TYR GLY ILE VAL
SEQRES 109 B 1887  ALA MET ALA ALA THR ALA THR ASP LYS ILE GLY ARG SER
SEQRES 110 B 1887  VAL PRO ALA PRO GLY LYS GLY ILE LEU THR THR ALA ARG
SEQRES 111 B 1887  GLU HIS HIS SER SER VAL LYS TYR ALA SER PRO ASN LEU
SEQRES 112 B 1887  ASN MET LYS TYR ARG LYS ARG GLN LEU VAL THR ARG GLU
SEQRES 113 B 1887  ALA GLN ILE LYS ASP TRP VAL GLU ASN GLU LEU GLU ALA
SEQRES 114 B 1887  LEU LYS LEU GLU ALA GLU GLU ILE PRO SER GLU ASP GLN
SEQRES 115 B 1887  ASN GLU PHE LEU LEU GLU ARG THR ARG GLU ILE HIS ASN
SEQRES 116 B 1887  GLU ALA GLU SER GLN LEU ARG ALA ALA GLN GLN GLN TRP
SEQRES 117 B 1887  GLY ASN ASP PHE TYR LYS ARG ASP PRO ARG ILE ALA PRO
SEQRES 118 B 1887  LEU ARG GLY ALA LEU ALA THR TYR GLY LEU THR ILE ASP
SEQRES 119 B 1887  ASP LEU GLY VAL ALA SER PHE HIS GLY THR SER THR LYS
SEQRES 120 B 1887  ALA ASN ASP LYS ASN GLU SER ALA THR ILE ASN GLU MET
SEQRES 121 B 1887  MET LYS HIS LEU GLY ARG SER GLU GLY ASN PRO VAL ILE
SEQRES 122 B 1887  GLY VAL PHE GLN LYS PHE LEU THR GLY HIS PRO LYS GLY
SEQRES 123 B 1887  ALA ALA GLY ALA TRP MET MET ASN GLY ALA LEU GLN ILE
SEQRES 124 B 1887  LEU ASN SER GLY ILE ILE PRO GLY ASN ARG ASN ALA ASP
SEQRES 125 B 1887  ASN VAL ASP LYS ILE LEU GLU GLN PHE GLU TYR VAL LEU
SEQRES 126 B 1887  TYR PRO SER LYS THR LEU LYS THR ASP GLY VAL ARG ALA
SEQRES 127 B 1887  VAL SER ILE THR SER PHE GLY PHE GLY GLN LYS GLY GLY
SEQRES 128 B 1887  GLN ALA ILE VAL VAL HIS PRO ASP TYR LEU TYR GLY ALA
SEQRES 129 B 1887  ILE THR GLU ASP ARG TYR ASN GLU TYR VAL ALA LYS VAL
SEQRES 130 B 1887  SER ALA ARG GLU LYS SER ALA TYR LYS PHE PHE HIS ASN
SEQRES 131 B 1887  GLY MET ILE TYR ASN LYS LEU PHE VAL SER LYS GLU HIS
SEQRES 132 B 1887  ALA PRO TYR THR ASP GLU LEU GLU GLU ASP VAL TYR LEU
SEQRES 133 B 1887  ASP PRO LEU ALA ARG VAL SER LYS ASP LYS LYS SER GLY
SEQRES 134 B 1887  SER LEU THR PHE ASN SER LYS ASN ILE GLN SER LYS ASP
SEQRES 135 B 1887  SER TYR ILE ASN ALA ASN THR ILE GLU THR ALA LYS MET
SEQRES 136 B 1887  ILE GLU ASN MET THR LYS GLU LYS VAL SER ASN GLY GLY
SEQRES 137 B 1887  VAL GLY VAL ASP VAL GLU LEU ILE THR SER ILE ASN VAL
SEQRES 138 B 1887  GLU ASN ASP THR PHE ILE GLU ARG ASN PHE THR PRO GLN
SEQRES 139 B 1887  GLU ILE GLU TYR CYS SER ALA GLN PRO SER VAL GLN SER
SEQRES 140 B 1887  SER PHE ALA GLY THR TRP SER ALA LYS GLU ALA VAL PHE
SEQRES 141 B 1887  LYS SER LEU GLY VAL LYS SER LEU GLY GLY GLY ALA ALA
SEQRES 142 B 1887  LEU LYS ASP ILE GLU ILE VAL ARG VAL ASN LYS ASN ALA
SEQRES 143 B 1887  PRO ALA VAL GLU LEU HIS GLY ASN ALA LYS LYS ALA ALA
SEQRES 144 B 1887  GLU GLU ALA GLY VAL THR ASP VAL LYS VAL SER ILE SER
SEQRES 145 B 1887  HIS ASP ASP LEU GLN ALA VAL ALA VAL ALA VAL SER THR
SEQRES 146 B 1887  LYS LYS
SEQRES   1 C 1887  MET LYS PRO GLU VAL GLU GLN GLU LEU ALA HIS ILE LEU
SEQRES   2 C 1887  LEU THR GLU LEU LEU ALA TYR GLN PHE ALA SER PRO VAL
SEQRES   3 C 1887  ARG TRP ILE GLU THR GLN ASP VAL PHE LEU LYS ASP PHE
SEQRES   4 C 1887  ASN THR GLU ARG VAL VAL GLU ILE GLY PRO SER PRO THR
SEQRES   5 C 1887  LEU ALA GLY MET ALA GLN ARG THR LEU LYS ASN LYS TYR
SEQRES   6 C 1887  GLU SER TYR ASP ALA ALA LEU SER LEU HIS ARG GLU ILE
SEQRES   7 C 1887  LEU CYS TYR SER LYS ASP ALA LYS GLU ILE TYR TYR THR
SEQRES   8 C 1887  PRO ASP PRO SER GLU LEU ALA ALA LYS GLU GLU PRO ALA
SEQRES   9 C 1887  LYS GLU GLU ALA PRO ALA PRO THR PRO ALA ALA SER ALA
SEQRES  10 C 1887  PRO ALA PRO ALA ALA ALA ALA PRO ALA PRO VAL ALA ALA
SEQRES  11 C 1887  ALA ALA PRO ALA ALA ALA ALA ALA GLU ILE ALA ASP GLU
SEQRES  12 C 1887  PRO VAL LYS ALA SER LEU LEU LEU HIS VAL LEU VAL ALA
SEQRES  13 C 1887  HIS LYS LEU LYS LYS SER LEU ASP SER ILE PRO MET SER
SEQRES  14 C 1887  LYS THR ILE LYS ASP LEU VAL GLY GLY LYS GVL THR VAL
SEQRES  15 C 1887  GLN ASN GLU ILE LEU GLY ASP LEU GLY LYS GLU PHE GLY
SEQRES  16 C 1887  THR THR PRO GLU LYS PRO GLU GLU THR PRO LEU GLU GLU
SEQRES  17 C 1887  LEU ALA GLU THR PHE GLN ASP THR PHE SER GLY ALA LEU
SEQRES  18 C 1887  GLY LYS GLN SER SER SER LEU LEU SER ARG LEU ILE SER
SEQRES  19 C 1887  SER LYS MET PRO GLY GLY PHE THR ILE THR VAL ALA ARG
SEQRES  20 C 1887  LYS TYR LEU GLN THR ARG TRP GLY LEU PRO SER GLY ARG
SEQRES  21 C 1887  GLN ASP GLY VAL LEU LEU VAL ALA LEU SER ASN GLU PRO
SEQRES  22 C 1887  ALA ALA ARG LEU GLY SER GLU ALA ASP ALA LYS ALA PHE
SEQRES  23 C 1887  LEU ASP SER MET ALA GLN LYS TYR ALA SER ILE VAL GLY
SEQRES  24 C 1887  VAL ASP LEU SER SER ALA ALA SER ALA SER GLY ALA ALA
SEQRES  25 C 1887  GLY ALA GLY ALA ALA ALA GLY ALA ALA MET ILE ASP ALA
SEQRES  26 C 1887  GLY ALA LEU GLU GLU ILE THR LYS ASP HIS LYS VAL LEU
SEQRES  27 C 1887  ALA ARG GLN GLN LEU GLN VAL LEU ALA ARG TYR LEU LYS
SEQRES  28 C 1887  MET ASP LEU ASP ASN GLY GLU ARG LYS PHE LEU LYS GLU
SEQRES  29 C 1887  LYS ASP THR VAL ALA GLU LEU GLN ALA GLN LEU ASP TYR
SEQRES  30 C 1887  LEU ASN ALA GLU LEU GLY GLU PHE PHE VAL ASN GLY VAL
SEQRES  31 C 1887  ALA THR SER PHE SER ARG LYS LYS ALA ARG THR PHE ASP
SEQRES  32 C 1887  SER SER TRP ASN TRP ALA LYS GLN SER LEU LEU SER LEU
SEQRES  33 C 1887  TYR PHE GLU ILE ILE HIS GLY VAL LEU LYS ASN VAL ASP
SEQRES  34 C 1887  ARG GLU VAL VAL SER GLU ALA ILE ASN ILE MET ASN ARG
SEQRES  35 C 1887  SER ASN ASP ALA LEU ILE LYS PHE MET GLU TYR HIS ILE
SEQRES  36 C 1887  SER ASN THR ASP GLU THR LYS GLY GLU ASN TYR GLN LEU
SEQRES  37 C 1887  VAL LYS THR LEU GLY GLU GLN LEU ILE GLU ASN CYS LYS
SEQRES  38 C 1887  GLN VAL LEU ASP VAL ASP PRO VAL TYR LYS ASP VAL ALA
SEQRES  39 C 1887  LYS PRO THR GLY PRO LYS THR ALA ILE ASP LYS ASN GLY
SEQRES  40 C 1887  ASN ILE THR TYR SER GLU GLU PRO ARG GLU LYS VAL ARG
SEQRES  41 C 1887  LYS LEU SER GLN TYR VAL GLN GLU MET ALA LEU GLY GLY
SEQRES  42 C 1887  PRO ILE THR LYS GLU SER GLN PRO THR ILE GLU GLU ASP
SEQRES  43 C 1887  LEU THR ARG VAL TYR LYS ALA ILE SER ALA GLN ALA ASP
SEQRES  44 C 1887  LYS GLN ASP ILE SER SER SER THR ARG VAL GLU PHE GLU
SEQRES  45 C 1887  LYS LEU TYR SER ASP LEU MET LYS PHE LEU GLU SER SER
SEQRES  46 C 1887  LYS GLU ILE ASP PRO SER GLN THR THR GLN LEU ALA GLY
SEQRES  47 C 1887  MET ASP VAL GLU ASP ALA LEU ASP LYS ASP SER THR LYS
SEQRES  48 C 1887  GLU VAL ALA SER LEU PRO ASN LYS SER THR ILE SER LYS
SEQRES  49 C 1887  THR VAL SER SER THR ILE PRO ARG GLU THR ILE PRO PHE
SEQRES  50 C 1887  LEU HIS LEU ARG LYS LYS THR PRO ALA GLY ASP TRP LYS
SEQRES  51 C 1887  TYR ASP ARG GLN LEU SER SER LEU PHE LEU ASP GLY LEU
SEQRES  52 C 1887  GLU LYS ALA ALA PHE ASN GLY VAL THR PHE LYS ASP LYS
SEQRES  53 C 1887  TYR VAL LEU ILE THR GLY ALA GLY LYS GLY SER ILE GLY
SEQRES  54 C 1887  ALA GLU VAL LEU GLN GLY LEU LEU GLN GLY GLY ALA LYS
SEQRES  55 C 1887  VAL VAL VAL THR THR SER ARG PHE SER LYS GLN VAL THR
SEQRES  56 C 1887  ASP TYR TYR GLN SER ILE TYR ALA LYS TYR GLY ALA LYS
SEQRES  57 C 1887  GLY SER THR LEU ILE VAL VAL PRO PHE ASN GLN GLY SER
SEQRES  58 C 1887  LYS GLN ASP VAL GLU ALA LEU ILE GLU PHE ILE TYR ASP
SEQRES  59 C 1887  THR GLU LYS ASN GLY GLY LEU GLY TRP ASP LEU ASP ALA
SEQRES  60 C 1887  ILE ILE PRO PHE ALA ALA ILE PRO GLU GLN GLY ILE GLU
SEQRES  61 C 1887  LEU GLU HIS ILE ASP SER LYS SER GLU PHE ALA HIS ARG
SEQRES  62 C 1887  ILE MET LEU THR ASN ILE LEU ARG MET MET GLY CYS VAL
SEQRES  63 C 1887  LYS LYS GLN LYS SER ALA ARG GLY ILE GLU THR ARG PRO
SEQRES  64 C 1887  ALA GLN VAL ILE LEU PRO MET SER PRO ASN HIS GLY THR
SEQRES  65 C 1887  PHE GLY GLY ASP GLY MET TYR SER GLU SER LYS LEU SER
SEQRES  66 C 1887  LEU GLU THR LEU PHE ASN ARG TRP HIS SER GLU SER TRP
SEQRES  67 C 1887  ALA ASN GLN LEU THR VAL CYS GLY ALA ILE ILE GLY TRP
SEQRES  68 C 1887  THR ARG GLY THR GLY LEU MET SER ALA ASN ASN ILE ILE
SEQRES  69 C 1887  ALA GLU GLY ILE GLU LYS MET GLY VAL ARG THR PHE SER
SEQRES  70 C 1887  GLN LYS GLU MET ALA PHE ASN LEU LEU GLY LEU LEU THR
SEQRES  71 C 1887  PRO GLU VAL VAL GLU LEU CYS GLN LYS SER PRO VAL MET
SEQRES  72 C 1887  ALA ASP LEU ASN GLY GLY LEU GLN PHE VAL PRO GLU LEU
SEQRES  73 C 1887  LYS GLU PHE THR ALA LYS LEU ARG LYS GLU LEU VAL GLU
SEQRES  74 C 1887  THR SER GLU VAL ARG LYS ALA VAL SER ILE GLU THR ALA
SEQRES  75 C 1887  LEU GLU HIS LYS VAL VAL ASN GLY ASN SER ALA ASP ALA
SEQRES  76 C 1887  ALA TYR ALA GLN VAL GLU ILE GLN PRO ARG ALA ASN ILE
SEQRES  77 C 1887  GLN LEU ASP PHE PRO GLU LEU LYS PRO TYR LYS GLN VAL
SEQRES  78 C 1887  LYS GLN ILE ALA PRO ALA GLU LEU GLU GLY LEU LEU ASP
SEQRES  79 C 1887  LEU GLU ARG VAL ILE VAL VAL THR GLY PHE ALA GLU VAL
SEQRES  80 C 1887  GLY PRO TRP GLY SER ALA ARG THR ARG TRP GLU MET GLU
SEQRES  81 C 1887  ALA PHE GLY GLU PHE SER LEU GLU GLY CYS VAL GLU MET
SEQRES  82 C 1887  ALA TRP ILE MET GLY PHE ILE SER TYR HIS ASN GLY ASN
SEQRES  83 C 1887  LEU LYS GLY ARG PRO TYR THR GLY TRP VAL ASP SER LYS
SEQRES  84 C 1887  THR LYS GLU PRO VAL ASP ASP LYS ASP VAL LYS ALA LYS
SEQRES  85 C 1887  TYR GLU THR SER ILE LEU GLU HIS SER GLY ILE ARG LEU
SEQRES  86 C 1887  ILE GLU PRO GLU LEU PHE ASN GLY TYR ASN PRO GLU LYS
SEQRES  87 C 1887  LYS GLU MET ILE GLN GLU VAL ILE VAL GLU GLU ASP LEU
SEQRES  88 C 1887  GLU PRO PHE GLU ALA SER LYS GLU THR ALA GLU GLN PHE
SEQRES  89 C 1887  LYS HIS GLN HIS GLY ASP LYS VAL ASP ILE PHE GLU ILE
SEQRES  90 C 1887  PRO GLU THR GLY GLU TYR SER VAL LYS LEU LEU LYS GLY
SEQRES  91 C 1887  ALA THR LEU TYR ILE PRO LYS ALA LEU ARG PHE ASP ARG
SEQRES  92 C 1887  LEU VAL ALA GLY GLN ILE PRO THR GLY TRP ASN ALA LYS
SEQRES  93 C 1887  THR TYR GLY ILE SER ASP ASP ILE ILE SER GLN VAL ASP
SEQRES  94 C 1887  PRO ILE THR LEU PHE VAL LEU VAL SER VAL VAL GLU ALA
SEQRES  95 C 1887  PHE ILE ALA SER GLY ILE THR ASP PRO TYR GLU MET TYR
SEQRES  96 C 1887  LYS TYR VAL HIS VAL SER GLU VAL GLY ASN CYS SER GLY
SEQRES  97 C 1887  SER GLY MET GLY GLY VAL SER ALA LEU ARG GLY MET PHE
SEQRES  98 C 1887  LYS ASP ARG PHE LYS ASP GLU PRO VAL GLN ASN ASP ILE
SEQRES  99 C 1887  LEU GLN GLU SER PHE ILE ASN THR MET SER ALA TRP VAL
SEQRES 100 C 1887  ASN MET LEU LEU ILE SER SER SER GLY PRO ILE LYS THR
SEQRES 101 C 1887  PRO VAL GLY ALA CYS ALA THR SER VAL GLU SER VAL ASP
SEQRES 102 C 1887  ILE GLY VAL GLU THR ILE LEU SER GLY LYS ALA ARG ILE
SEQRES 103 C 1887  CYS ILE VAL GLY GLY TYR ASP ASP PHE GLN GLU GLU GLY
SEQRES 104 C 1887  SER PHE GLU PHE GLY ASN MET LYS ALA THR SER ASN THR
SEQRES 105 C 1887  LEU GLU GLU PHE GLU HIS GLY ARG THR PRO ALA GLU MET
SEQRES 106 C 1887  SER ARG PRO ALA THR THR THR ARG ASN GLY PHE MET GLU
SEQRES 107 C 1887  ALA GLN GLY ALA GLY ILE GLN ILE ILE MET GLN ALA ASP
SEQRES 108 C 1887  LEU ALA LEU LYS MET GLY VAL PRO ILE TYR GLY ILE VAL
SEQRES 109 C 1887  ALA MET ALA ALA THR ALA THR ASP LYS ILE GLY ARG SER
SEQRES 110 C 1887  VAL PRO ALA PRO GLY LYS GLY ILE LEU THR THR ALA ARG
SEQRES 111 C 1887  GLU HIS HIS SER SER VAL LYS TYR ALA SER PRO ASN LEU
SEQRES 112 C 1887  ASN MET LYS TYR ARG LYS ARG GLN LEU VAL THR ARG GLU
SEQRES 113 C 1887  ALA GLN ILE LYS ASP TRP VAL GLU ASN GLU LEU GLU ALA
SEQRES 114 C 1887  LEU LYS LEU GLU ALA GLU GLU ILE PRO SER GLU ASP GLN
SEQRES 115 C 1887  ASN GLU PHE LEU LEU GLU ARG THR ARG GLU ILE HIS ASN
SEQRES 116 C 1887  GLU ALA GLU SER GLN LEU ARG ALA ALA GLN GLN GLN TRP
SEQRES 117 C 1887  GLY ASN ASP PHE TYR LYS ARG ASP PRO ARG ILE ALA PRO
SEQRES 118 C 1887  LEU ARG GLY ALA LEU ALA THR TYR GLY LEU THR ILE ASP
SEQRES 119 C 1887  ASP LEU GLY VAL ALA SER PHE HIS GLY THR SER THR LYS
SEQRES 120 C 1887  ALA ASN ASP LYS ASN GLU SER ALA THR ILE ASN GLU MET
SEQRES 121 C 1887  MET LYS HIS LEU GLY ARG SER GLU GLY ASN PRO VAL ILE
SEQRES 122 C 1887  GLY VAL PHE GLN LYS PHE LEU THR GLY HIS PRO LYS GLY
SEQRES 123 C 1887  ALA ALA GLY ALA TRP MET MET ASN GLY ALA LEU GLN ILE
SEQRES 124 C 1887  LEU ASN SER GLY ILE ILE PRO GLY ASN ARG ASN ALA ASP
SEQRES 125 C 1887  ASN VAL ASP LYS ILE LEU GLU GLN PHE GLU TYR VAL LEU
SEQRES 126 C 1887  TYR PRO SER LYS THR LEU LYS THR ASP GLY VAL ARG ALA
SEQRES 127 C 1887  VAL SER ILE THR SER PHE GLY PHE GLY GLN LYS GLY GLY
SEQRES 128 C 1887  GLN ALA ILE VAL VAL HIS PRO ASP TYR LEU TYR GLY ALA
SEQRES 129 C 1887  ILE THR GLU ASP ARG TYR ASN GLU TYR VAL ALA LYS VAL
SEQRES 130 C 1887  SER ALA ARG GLU LYS SER ALA TYR LYS PHE PHE HIS ASN
SEQRES 131 C 1887  GLY MET ILE TYR ASN LYS LEU PHE VAL SER LYS GLU HIS
SEQRES 132 C 1887  ALA PRO TYR THR ASP GLU LEU GLU GLU ASP VAL TYR LEU
SEQRES 133 C 1887  ASP PRO LEU ALA ARG VAL SER LYS ASP LYS LYS SER GLY
SEQRES 134 C 1887  SER LEU THR PHE ASN SER LYS ASN ILE GLN SER LYS ASP
SEQRES 135 C 1887  SER TYR ILE ASN ALA ASN THR ILE GLU THR ALA LYS MET
SEQRES 136 C 1887  ILE GLU ASN MET THR LYS GLU LYS VAL SER ASN GLY GLY
SEQRES 137 C 1887  VAL GLY VAL ASP VAL GLU LEU ILE THR SER ILE ASN VAL
SEQRES 138 C 1887  GLU ASN ASP THR PHE ILE GLU ARG ASN PHE THR PRO GLN
SEQRES 139 C 1887  GLU ILE GLU TYR CYS SER ALA GLN PRO SER VAL GLN SER
SEQRES 140 C 1887  SER PHE ALA GLY THR TRP SER ALA LYS GLU ALA VAL PHE
SEQRES 141 C 1887  LYS SER LEU GLY VAL LYS SER LEU GLY GLY GLY ALA ALA
SEQRES 142 C 1887  LEU LYS ASP ILE GLU ILE VAL ARG VAL ASN LYS ASN ALA
SEQRES 143 C 1887  PRO ALA VAL GLU LEU HIS GLY ASN ALA LYS LYS ALA ALA
SEQRES 144 C 1887  GLU GLU ALA GLY VAL THR ASP VAL LYS VAL SER ILE SER
SEQRES 145 C 1887  HIS ASP ASP LEU GLN ALA VAL ALA VAL ALA VAL SER THR
SEQRES 146 C 1887  LYS LYS
SEQRES   1 G 2051  MET ASP ALA TYR SER THR ARG PRO LEU THR LEU SER HIS
SEQRES   2 G 2051  GLY SER LEU GLU HIS VAL LEU LEU VAL PRO THR ALA SER
SEQRES   3 G 2051  PHE PHE ILE ALA SER GLN LEU GLN GLU GLN PHE ASN LYS
SEQRES   4 G 2051  ILE LEU PRO GLU PRO THR GLU GLY PHE ALA ALA ASP ASP
SEQRES   5 G 2051  GLU PRO THR THR PRO ALA GLU LEU VAL GLY LYS PHE LEU
SEQRES   6 G 2051  GLY TYR VAL SER SER LEU VAL GLU PRO SER LYS VAL GLY
SEQRES   7 G 2051  GLN PHE ASP GLN VAL LEU ASN LEU CYS LEU THR GLU PHE
SEQRES   8 G 2051  GLU ASN CYS TYR LEU GLU GLY ASN ASP ILE HIS ALA LEU
SEQRES   9 G 2051  ALA ALA LYS LEU LEU GLN GLU ASN ASP THR THR LEU VAL
SEQRES  10 G 2051  LYS THR LYS GLU LEU ILE LYS ASN TYR ILE THR ALA ARG
SEQRES  11 G 2051  ILE MET ALA LYS ARG PRO PHE ASP LYS LYS SER ASN SER
SEQRES  12 G 2051  ALA LEU PHE ARG ALA VAL GLY GLU GLY ASN ALA GLN LEU
SEQRES  13 G 2051  VAL ALA ILE PHE GLY GLY GLN GLY ASN THR ASP ASP TYR
SEQRES  14 G 2051  PHE GLU GLU LEU ARG ASP LEU TYR GLN THR TYR HIS VAL
SEQRES  15 G 2051  LEU VAL GLY ASP LEU ILE LYS PHE SER ALA GLU THR LEU
SEQRES  16 G 2051  SER GLU LEU ILE ARG THR THR LEU ASP ALA GLU LYS VAL
SEQRES  17 G 2051  PHE THR GLN GLY LEU ASN ILE LEU GLU TRP LEU GLU ASN
SEQRES  18 G 2051  PRO SER ASN THR PRO ASP LYS ASP TYR LEU LEU SER ILE
SEQRES  19 G 2051  PRO ILE SER CYS PRO LEU ILE GLY VAL ILE GLN LEU ALA
SEQRES  20 G 2051  HIS TYR VAL VAL THR ALA LYS LEU LEU GLY PHE THR PRO
SEQRES  21 G 2051  GLY GLU LEU ARG SER TYR LEU LYS GLY ALA THR GLY HIS
SEQRES  22 G 2051  SER GLN GLY LEU VAL THR ALA VAL ALA ILE ALA GLU THR
SEQRES  23 G 2051  ASP SER TRP GLU SER PHE PHE VAL SER VAL ARG LYS ALA
SEQRES  24 G 2051  ILE THR VAL LEU PHE PHE ILE GLY VAL ARG CYS TYR GLU
SEQRES  25 G 2051  ALA TYR PRO ASN THR SER LEU PRO PRO SER ILE LEU GLU
SEQRES  26 G 2051  ASP SER LEU GLU ASN ASN GLU GLY VAL PRO SER PRO MET
SEQRES  27 G 2051  LEU SER ILE SER ASN LEU THR GLN GLU GLN VAL GLN ASP
SEQRES  28 G 2051  TYR VAL ASN LYS THR ASN SER HIS LEU PRO ALA GLY LYS
SEQRES  29 G 2051  GLN VAL GLU ILE SER LEU VAL ASN GLY ALA LYS ASN LEU
SEQRES  30 G 2051  VAL VAL SER GLY PRO PRO GLN SER LEU TYR GLY LEU ASN
SEQRES  31 G 2051  LEU THR LEU ARG LYS ALA LYS ALA PRO SER GLY LEU ASP
SEQRES  32 G 2051  GLN SER ARG ILE PRO PHE SER GLU ARG LYS LEU LYS PHE
SEQRES  33 G 2051  SER ASN ARG PHE LEU PRO VAL ALA SER PRO PHE HIS SER
SEQRES  34 G 2051  HIS LEU LEU VAL PRO ALA SER ASP LEU ILE ASN LYS ASP
SEQRES  35 G 2051  LEU VAL LYS ASN ASN VAL SER PHE ASN ALA LYS ASP ILE
SEQRES  36 G 2051  GLN ILE PRO VAL TYR ASP THR PHE ASP GLY SER ASP LEU
SEQRES  37 G 2051  ARG VAL LEU SER GLY SER ILE SER GLU ARG ILE VAL ASP
SEQRES  38 G 2051  CYS ILE ILE ARG LEU PRO VAL LYS TRP GLU THR THR THR
SEQRES  39 G 2051  GLN PHE LYS ALA THR HIS ILE LEU ASP PHE GLY PRO GLY
SEQRES  40 G 2051  GLY ALA SER GLY LEU GLY VAL LEU THR HIS ARG ASN LYS
SEQRES  41 G 2051  ASP GLY THR GLY VAL ARG VAL ILE VAL ALA GLY THR LEU
SEQRES  42 G 2051  ASP ILE ASN PRO ASP ASP ASP TYR GLY PHE LYS GLN GLU
SEQRES  43 G 2051  ILE PHE ASP VAL THR SER ASN GLY LEU LYS LYS ASN PRO
SEQRES  44 G 2051  ASN TRP LEU GLU GLU TYR HIS PRO LYS LEU ILE LYS ASN
SEQRES  45 G 2051  LYS SER GLY LYS ILE PHE VAL GLU THR LYS PHE SER LYS
SEQRES  46 G 2051  LEU ILE GLY ARG PRO PRO LEU LEU VAL PRO GLY MET THR
SEQRES  47 G 2051  PRO CYS THR VAL SER PRO ASP PHE VAL ALA ALA THR THR
SEQRES  48 G 2051  ASN ALA GLY TYR THR ILE GLU LEU ALA GLY GLY GLY TYR
SEQRES  49 G 2051  PHE SER ALA ALA GLY MET THR ALA ALA ILE ASP SER VAL
SEQRES  50 G 2051  VAL SER GLN ILE GLU LYS GLY SER THR PHE GLY ILE ASN
SEQRES  51 G 2051  LEU ILE TYR VAL ASN PRO PHE MET LEU GLN TRP GLY ILE
SEQRES  52 G 2051  PRO LEU ILE LYS GLU LEU ARG SER LYS GLY TYR PRO ILE
SEQRES  53 G 2051  GLN PHE LEU THR ILE GLY ALA GLY VAL PRO SER LEU GLU
SEQRES  54 G 2051  VAL ALA SER GLU TYR ILE GLU THR LEU GLY LEU LYS TYR
SEQRES  55 G 2051  LEU GLY LEU LYS PRO GLY SER ILE ASP ALA ILE SER GLN
SEQRES  56 G 2051  VAL ILE ASN ILE ALA LYS ALA HIS PRO ASN PHE PRO ILE
SEQRES  57 G 2051  ALA LEU GLN TRP THR GLY GLY ARG GLY GLY GLY HIS HIS
SEQRES  58 G 2051  SER PHE GLU ASP ALA HIS THR PRO MET LEU GLN MET TYR
SEQRES  59 G 2051  SER LYS ILE ARG ARG HIS PRO ASN ILE MET LEU ILE PHE
SEQRES  60 G 2051  GLY SER GLY PHE GLY SER ALA ASP ASP THR TYR PRO TYR
SEQRES  61 G 2051  LEU THR GLY GLU TRP SER THR LYS PHE ASP TYR PRO PRO
SEQRES  62 G 2051  MET PRO PHE ASP GLY PHE LEU PHE GLY SER ARG VAL MET
SEQRES  63 G 2051  ILE ALA LYS GLU VAL LYS THR SER PRO ASP ALA LYS LYS
SEQRES  64 G 2051  CYS ILE ALA ALA CYS THR GLY VAL PRO ASP ASP LYS TRP
SEQRES  65 G 2051  GLU GLN THR TYR LYS LYS PRO THR GLY GLY ILE VAL THR
SEQRES  66 G 2051  VAL ARG SER GLU MET GLY GLU PRO ILE HIS LYS ILE ALA
SEQRES  67 G 2051  THR ARG GLY VAL MET LEU TRP LYS GLU PHE ASP GLU THR
SEQRES  68 G 2051  ILE PHE ASN LEU PRO LYS ASN LYS LEU VAL PRO THR LEU
SEQRES  69 G 2051  GLU ALA LYS ARG ASP TYR ILE ILE SER ARG LEU ASN ALA
SEQRES  70 G 2051  ASP PHE GLN LYS PRO TRP PHE ALA THR VAL ASN GLY GLN
SEQRES  71 G 2051  ALA ARG ASP LEU ALA THR MET THR TYR GLU GLU VAL ALA
SEQRES  72 G 2051  LYS ARG LEU VAL GLU LEU MET PHE ILE ARG SER THR ASN
SEQRES  73 G 2051  SER TRP PHE ASP VAL THR TRP ARG THR PHE THR GLY ASP
SEQRES  74 G 2051  PHE LEU ARG ARG VAL GLU GLU ARG PHE THR LYS SER LYS
SEQRES  75 G 2051  THR LEU SER LEU ILE GLN SER TYR SER LEU LEU ASP LYS
SEQRES  76 G 2051  PRO ASP GLU ALA ILE GLU LYS VAL PHE ASN ALA TYR PRO
SEQRES  77 G 2051  ALA ALA ARG GLU GLN PHE LEU ASN ALA GLN ASP ILE ASP
SEQRES  78 G 2051  HIS PHE LEU SER MET CYS GLN ASN PRO MET GLN LYS PRO
SEQRES  79 G 2051  VAL PRO PHE VAL PRO VAL LEU ASP ARG ARG PHE GLU ILE
SEQRES  80 G 2051  PHE PHE LYS LYS ASP SER LEU TRP GLN SER GLU HIS LEU
SEQRES  81 G 2051  GLU ALA VAL VAL ASP GLN ASP VAL GLN ARG THR CYS ILE
SEQRES  82 G 2051  LEU HIS GLY PRO VAL ALA ALA GLN PHE THR LYS VAL ILE
SEQRES  83 G 2051  ASP GLU PRO ILE LYS SER ILE MET ASP GLY ILE HIS ASP
SEQRES  84 G 2051  GLY HIS ILE LYS LYS LEU LEU HIS GLN TYR TYR GLY ASP
SEQRES  85 G 2051  ASP GLU SER LYS ILE PRO ALA VAL GLU TYR PHE GLY GLY
SEQRES  86 G 2051  GLU SER PRO VAL ASP VAL GLN SER GLN VAL ASP SER SER
SEQRES  87 G 2051  SER VAL SER GLU ASP SER ALA VAL PHE LYS ALA THR SER
SEQRES  88 G 2051  SER THR ASP GLU GLU SER TRP PHE LYS ALA LEU ALA GLY
SEQRES  89 G 2051  SER GLU ILE ASN TRP ARG HIS ALA SER PHE LEU CYS SER
SEQRES  90 G 2051  PHE ILE THR GLN ASP LYS MET PHE VAL SER ASN PRO ILE
SEQRES  91 G 2051  ARG LYS VAL PHE LYS PRO SER GLN GLY MET VAL VAL GLU
SEQRES  92 G 2051  ILE SER ASN GLY ASN THR SER SER LYS THR VAL VAL THR
SEQRES  93 G 2051  LEU SER GLU PRO VAL GLN GLY GLU LEU LYS PRO THR VAL
SEQRES  94 G 2051  ILE LEU LYS LEU LEU LYS GLU ASN ILE ILE GLN MET GLU
SEQRES  95 G 2051  MET ILE GLU ASN ARG THR MET ASP GLY LYS PRO VAL SER
SEQRES  96 G 2051  LEU PRO LEU LEU TYR ASN PHE ASN PRO ASP ASN GLY PHE
SEQRES  97 G 2051  ALA PRO ILE SER GLU VAL MET GLU ASP ARG ASN GLN ARG
SEQRES  98 G 2051  ILE LYS GLU MET TYR TRP LYS LEU TRP ILE ASP GLU PRO
SEQRES  99 G 2051  PHE ASN LEU ASP PHE ASP PRO ARG ASP VAL ILE LYS GLY
SEQRES 100 G 2051  LYS ASP PHE GLU ILE THR ALA LYS GLU VAL TYR ASP PHE
SEQRES 101 G 2051  THR HIS ALA VAL GLY ASN ASN CYS GLU ASP PHE VAL SER
SEQRES 102 G 2051  ARG PRO ASP ARG THR MET LEU ALA PRO MET ASP PHE ALA
SEQRES 103 G 2051  ILE VAL VAL GLY TRP ARG ALA ILE ILE LYS ALA ILE PHE
SEQRES 104 G 2051  PRO ASN THR VAL ASP GLY ASP LEU LEU LYS LEU VAL HIS
SEQRES 105 G 2051  LEU SER ASN GLY TYR LYS MET ILE PRO GLY ALA LYS PRO
SEQRES 106 G 2051  LEU GLN VAL GLY ASP VAL VAL SER THR THR ALA VAL ILE
SEQRES 107 G 2051  GLU SER VAL VAL ASN GLN PRO THR GLY LYS ILE VAL ASP
SEQRES 108 G 2051  VAL VAL GLY THR LEU SER ARG ASN GLY LYS PRO VAL MET
SEQRES 109 G 2051  GLU VAL THR SER SER PHE PHE TYR ARG GLY ASN TYR THR
SEQRES 110 G 2051  ASP PHE GLU ASN THR PHE GLN LYS THR VAL GLU PRO VAL
SEQRES 111 G 2051  TYR GLN MET HIS ILE LYS THR SER LYS ASP ILE ALA VAL
SEQRES 112 G 2051  LEU ARG SER LYS GLU TRP PHE GLN LEU ASP ASP GLU ASP
SEQRES 113 G 2051  PHE ASP LEU LEU ASN LYS THR LEU THR PHE GLU THR GLU
SEQRES 114 G 2051  THR GLU VAL THR PHE LYS ASN ALA ASN ILE PHE SER SER
SEQRES 115 G 2051  VAL LYS CYS PHE GLY PRO ILE LYS VAL GLU LEU PRO THR
SEQRES 116 G 2051  LYS GLU THR VAL GLU ILE GLY ILE VAL ASP TYR GLU ALA
SEQRES 117 G 2051  GLY ALA SER HIS GLY ASN PRO VAL VAL ASP PHE LEU LYS
SEQRES 118 G 2051  ARG ASN GLY SER THR LEU GLU GLN LYS VAL ASN LEU GLU
SEQRES 119 G 2051  ASN PRO ILE PRO ILE ALA VAL LEU ASP SER TYR THR PRO
SEQRES 120 G 2051  SER THR ASN GLU PRO TYR ALA ARG VAL SER GLY ASP LEU
SEQRES 121 G 2051  ASN PRO ILE HIS VAL SER ARG HIS PHE ALA SER TYR ALA
SEQRES 122 G 2051  ASN LEU PRO GLY THR ILE THR HIS GLY MET PHE SER SER
SEQRES 123 G 2051  ALA SER VAL ARG ALA LEU ILE GLU ASN TRP ALA ALA ASP
SEQRES 124 G 2051  SER VAL SER SER ARG VAL ARG GLY TYR THR CYS GLN PHE
SEQRES 125 G 2051  VAL ASP MET VAL LEU PRO ASN THR ALA LEU LYS THR SER
SEQRES 126 G 2051  ILE GLN HIS VAL GLY MET ILE ASN GLY ARG LYS LEU ILE
SEQRES 127 G 2051  LYS PHE GLU THR ARG ASN GLU ASP ASP VAL VAL VAL LEU
SEQRES 128 G 2051  THR GLY GLU ALA GLU ILE GLU GLN PRO VAL THR THR PHE
SEQRES 129 G 2051  VAL PHE THR GLY GLN GLY SER GLN GLU GLN GLY MET GLY
SEQRES 130 G 2051  MET ASP LEU TYR LYS THR SER LYS ALA ALA GLN ASP VAL
SEQRES 131 G 2051  TRP ASN ARG ALA ASP ASN HIS PHE LYS ASP THR TYR GLY
SEQRES 132 G 2051  PHE SER ILE LEU ASP ILE VAL ILE ASN ASN PRO VAL ASN
SEQRES 133 G 2051  LEU THR ILE HIS PHE GLY GLY GLU LYS GLY LYS ARG ILE
SEQRES 134 G 2051  ARG GLU ASN TYR SER ALA MET ILE PHE GLU THR ILE VAL
SEQRES 135 G 2051  ASP GLY LYS LEU LYS THR GLU LYS ILE PHE LYS GLU ILE
SEQRES 136 G 2051  ASN GLU HIS SER THR SER TYR THR PHE ARG SER GLU LYS
SEQRES 137 G 2051  GLY LEU LEU SER ALA THR GLN PHE THR GLN PRO ALA LEU
SEQRES 138 G 2051  THR LEU MET GLU LYS ALA ALA PHE GLU ASP LEU LYS SER
SEQRES 139 G 2051  LYS GLY LEU ILE PRO ALA ASP ALA THR PHE ALA GLY HIS
SEQRES 140 G 2051  SER LEU GLY GLU TYR ALA ALA LEU ALA SER LEU ALA ASP
SEQRES 141 G 2051  VAL MET SER ILE GLU SER LEU VAL GLU VAL VAL PHE TYR
SEQRES 142 G 2051  ARG GLY MET THR MET GLN VAL ALA VAL PRO ARG ASP GLU
SEQRES 143 G 2051  LEU GLY ARG SER ASN TYR GLY MET ILE ALA ILE ASN PRO
SEQRES 144 G 2051  GLY ARG VAL ALA ALA SER PHE SER GLN GLU ALA LEU GLN
SEQRES 145 G 2051  TYR VAL VAL GLU ARG VAL GLY LYS ARG THR GLY TRP LEU
SEQRES 146 G 2051  VAL GLU ILE VAL ASN TYR ASN VAL GLU ASN GLN GLN TYR
SEQRES 147 G 2051  VAL ALA ALA GLY ASP LEU ARG ALA LEU ASP THR VAL THR
SEQRES 148 G 2051  ASN VAL LEU ASN PHE ILE LYS LEU GLN LYS ILE ASP ILE
SEQRES 149 G 2051  ILE GLU LEU GLN LYS SER LEU SER LEU GLU GLU VAL GLU
SEQRES 150 G 2051  GLY HIS LEU PHE GLU ILE ILE ASP GLU ALA SER LYS LYS
SEQRES 151 G 2051  SER ALA VAL LYS PRO ARG PRO LEU LYS LEU GLU ARG GLY
SEQRES 152 G 2051  PHE ALA CYS ILE PRO LEU VAL GLY ILE SER VAL PRO PHE
SEQRES 153 G 2051  HIS SER THR TYR LEU MET ASN GLY VAL LYS PRO PHE LYS
SEQRES 154 G 2051  SER PHE LEU LYS LYS ASN ILE ILE LYS GLU ASN VAL LYS
SEQRES 155 G 2051  VAL ALA ARG LEU ALA GLY LYS TYR ILE PRO ASN LEU THR
SEQRES 156 G 2051  ALA LYS PRO PHE GLN VAL THR LYS GLU TYR PHE GLN ASP
SEQRES 157 G 2051  VAL TYR ASP LEU THR GLY SER GLU PRO ILE LYS GLU ILE
SEQRES 158 G 2051  ILE ASP ASN TRP GLU LYS TYR GLU GLN SER
SEQRES   1 H 2051  MET ASP ALA TYR SER THR ARG PRO LEU THR LEU SER HIS
SEQRES   2 H 2051  GLY SER LEU GLU HIS VAL LEU LEU VAL PRO THR ALA SER
SEQRES   3 H 2051  PHE PHE ILE ALA SER GLN LEU GLN GLU GLN PHE ASN LYS
SEQRES   4 H 2051  ILE LEU PRO GLU PRO THR GLU GLY PHE ALA ALA ASP ASP
SEQRES   5 H 2051  GLU PRO THR THR PRO ALA GLU LEU VAL GLY LYS PHE LEU
SEQRES   6 H 2051  GLY TYR VAL SER SER LEU VAL GLU PRO SER LYS VAL GLY
SEQRES   7 H 2051  GLN PHE ASP GLN VAL LEU ASN LEU CYS LEU THR GLU PHE
SEQRES   8 H 2051  GLU ASN CYS TYR LEU GLU GLY ASN ASP ILE HIS ALA LEU
SEQRES   9 H 2051  ALA ALA LYS LEU LEU GLN GLU ASN ASP THR THR LEU VAL
SEQRES  10 H 2051  LYS THR LYS GLU LEU ILE LYS ASN TYR ILE THR ALA ARG
SEQRES  11 H 2051  ILE MET ALA LYS ARG PRO PHE ASP LYS LYS SER ASN SER
SEQRES  12 H 2051  ALA LEU PHE ARG ALA VAL GLY GLU GLY ASN ALA GLN LEU
SEQRES  13 H 2051  VAL ALA ILE PHE GLY GLY GLN GLY ASN THR ASP ASP TYR
SEQRES  14 H 2051  PHE GLU GLU LEU ARG ASP LEU TYR GLN THR TYR HIS VAL
SEQRES  15 H 2051  LEU VAL GLY ASP LEU ILE LYS PHE SER ALA GLU THR LEU
SEQRES  16 H 2051  SER GLU LEU ILE ARG THR THR LEU ASP ALA GLU LYS VAL
SEQRES  17 H 2051  PHE THR GLN GLY LEU ASN ILE LEU GLU TRP LEU GLU ASN
SEQRES  18 H 2051  PRO SER ASN THR PRO ASP LYS ASP TYR LEU LEU SER ILE
SEQRES  19 H 2051  PRO ILE SER CYS PRO LEU ILE GLY VAL ILE GLN LEU ALA
SEQRES  20 H 2051  HIS TYR VAL VAL THR ALA LYS LEU LEU GLY PHE THR PRO
SEQRES  21 H 2051  GLY GLU LEU ARG SER TYR LEU LYS GLY ALA THR GLY HIS
SEQRES  22 H 2051  SER GLN GLY LEU VAL THR ALA VAL ALA ILE ALA GLU THR
SEQRES  23 H 2051  ASP SER TRP GLU SER PHE PHE VAL SER VAL ARG LYS ALA
SEQRES  24 H 2051  ILE THR VAL LEU PHE PHE ILE GLY VAL ARG CYS TYR GLU
SEQRES  25 H 2051  ALA TYR PRO ASN THR SER LEU PRO PRO SER ILE LEU GLU
SEQRES  26 H 2051  ASP SER LEU GLU ASN ASN GLU GLY VAL PRO SER PRO MET
SEQRES  27 H 2051  LEU SER ILE SER ASN LEU THR GLN GLU GLN VAL GLN ASP
SEQRES  28 H 2051  TYR VAL ASN LYS THR ASN SER HIS LEU PRO ALA GLY LYS
SEQRES  29 H 2051  GLN VAL GLU ILE SER LEU VAL ASN GLY ALA LYS ASN LEU
SEQRES  30 H 2051  VAL VAL SER GLY PRO PRO GLN SER LEU TYR GLY LEU ASN
SEQRES  31 H 2051  LEU THR LEU ARG LYS ALA LYS ALA PRO SER GLY LEU ASP
SEQRES  32 H 2051  GLN SER ARG ILE PRO PHE SER GLU ARG LYS LEU LYS PHE
SEQRES  33 H 2051  SER ASN ARG PHE LEU PRO VAL ALA SER PRO PHE HIS SER
SEQRES  34 H 2051  HIS LEU LEU VAL PRO ALA SER ASP LEU ILE ASN LYS ASP
SEQRES  35 H 2051  LEU VAL LYS ASN ASN VAL SER PHE ASN ALA LYS ASP ILE
SEQRES  36 H 2051  GLN ILE PRO VAL TYR ASP THR PHE ASP GLY SER ASP LEU
SEQRES  37 H 2051  ARG VAL LEU SER GLY SER ILE SER GLU ARG ILE VAL ASP
SEQRES  38 H 2051  CYS ILE ILE ARG LEU PRO VAL LYS TRP GLU THR THR THR
SEQRES  39 H 2051  GLN PHE LYS ALA THR HIS ILE LEU ASP PHE GLY PRO GLY
SEQRES  40 H 2051  GLY ALA SER GLY LEU GLY VAL LEU THR HIS ARG ASN LYS
SEQRES  41 H 2051  ASP GLY THR GLY VAL ARG VAL ILE VAL ALA GLY THR LEU
SEQRES  42 H 2051  ASP ILE ASN PRO ASP ASP ASP TYR GLY PHE LYS GLN GLU
SEQRES  43 H 2051  ILE PHE ASP VAL THR SER ASN GLY LEU LYS LYS ASN PRO
SEQRES  44 H 2051  ASN TRP LEU GLU GLU TYR HIS PRO LYS LEU ILE LYS ASN
SEQRES  45 H 2051  LYS SER GLY LYS ILE PHE VAL GLU THR LYS PHE SER LYS
SEQRES  46 H 2051  LEU ILE GLY ARG PRO PRO LEU LEU VAL PRO GLY MET THR
SEQRES  47 H 2051  PRO CYS THR VAL SER PRO ASP PHE VAL ALA ALA THR THR
SEQRES  48 H 2051  ASN ALA GLY TYR THR ILE GLU LEU ALA GLY GLY GLY TYR
SEQRES  49 H 2051  PHE SER ALA ALA GLY MET THR ALA ALA ILE ASP SER VAL
SEQRES  50 H 2051  VAL SER GLN ILE GLU LYS GLY SER THR PHE GLY ILE ASN
SEQRES  51 H 2051  LEU ILE TYR VAL ASN PRO PHE MET LEU GLN TRP GLY ILE
SEQRES  52 H 2051  PRO LEU ILE LYS GLU LEU ARG SER LYS GLY TYR PRO ILE
SEQRES  53 H 2051  GLN PHE LEU THR ILE GLY ALA GLY VAL PRO SER LEU GLU
SEQRES  54 H 2051  VAL ALA SER GLU TYR ILE GLU THR LEU GLY LEU LYS TYR
SEQRES  55 H 2051  LEU GLY LEU LYS PRO GLY SER ILE ASP ALA ILE SER GLN
SEQRES  56 H 2051  VAL ILE ASN ILE ALA LYS ALA HIS PRO ASN PHE PRO ILE
SEQRES  57 H 2051  ALA LEU GLN TRP THR GLY GLY ARG GLY GLY GLY HIS HIS
SEQRES  58 H 2051  SER PHE GLU ASP ALA HIS THR PRO MET LEU GLN MET TYR
SEQRES  59 H 2051  SER LYS ILE ARG ARG HIS PRO ASN ILE MET LEU ILE PHE
SEQRES  60 H 2051  GLY SER GLY PHE GLY SER ALA ASP ASP THR TYR PRO TYR
SEQRES  61 H 2051  LEU THR GLY GLU TRP SER THR LYS PHE ASP TYR PRO PRO
SEQRES  62 H 2051  MET PRO PHE ASP GLY PHE LEU PHE GLY SER ARG VAL MET
SEQRES  63 H 2051  ILE ALA LYS GLU VAL LYS THR SER PRO ASP ALA LYS LYS
SEQRES  64 H 2051  CYS ILE ALA ALA CYS THR GLY VAL PRO ASP ASP LYS TRP
SEQRES  65 H 2051  GLU GLN THR TYR LYS LYS PRO THR GLY GLY ILE VAL THR
SEQRES  66 H 2051  VAL ARG SER GLU MET GLY GLU PRO ILE HIS LYS ILE ALA
SEQRES  67 H 2051  THR ARG GLY VAL MET LEU TRP LYS GLU PHE ASP GLU THR
SEQRES  68 H 2051  ILE PHE ASN LEU PRO LYS ASN LYS LEU VAL PRO THR LEU
SEQRES  69 H 2051  GLU ALA LYS ARG ASP TYR ILE ILE SER ARG LEU ASN ALA
SEQRES  70 H 2051  ASP PHE GLN LYS PRO TRP PHE ALA THR VAL ASN GLY GLN
SEQRES  71 H 2051  ALA ARG ASP LEU ALA THR MET THR TYR GLU GLU VAL ALA
SEQRES  72 H 2051  LYS ARG LEU VAL GLU LEU MET PHE ILE ARG SER THR ASN
SEQRES  73 H 2051  SER TRP PHE ASP VAL THR TRP ARG THR PHE THR GLY ASP
SEQRES  74 H 2051  PHE LEU ARG ARG VAL GLU GLU ARG PHE THR LYS SER LYS
SEQRES  75 H 2051  THR LEU SER LEU ILE GLN SER TYR SER LEU LEU ASP LYS
SEQRES  76 H 2051  PRO ASP GLU ALA ILE GLU LYS VAL PHE ASN ALA TYR PRO
SEQRES  77 H 2051  ALA ALA ARG GLU GLN PHE LEU ASN ALA GLN ASP ILE ASP
SEQRES  78 H 2051  HIS PHE LEU SER MET CYS GLN ASN PRO MET GLN LYS PRO
SEQRES  79 H 2051  VAL PRO PHE VAL PRO VAL LEU ASP ARG ARG PHE GLU ILE
SEQRES  80 H 2051  PHE PHE LYS LYS ASP SER LEU TRP GLN SER GLU HIS LEU
SEQRES  81 H 2051  GLU ALA VAL VAL ASP GLN ASP VAL GLN ARG THR CYS ILE
SEQRES  82 H 2051  LEU HIS GLY PRO VAL ALA ALA GLN PHE THR LYS VAL ILE
SEQRES  83 H 2051  ASP GLU PRO ILE LYS SER ILE MET ASP GLY ILE HIS ASP
SEQRES  84 H 2051  GLY HIS ILE LYS LYS LEU LEU HIS GLN TYR TYR GLY ASP
SEQRES  85 H 2051  ASP GLU SER LYS ILE PRO ALA VAL GLU TYR PHE GLY GLY
SEQRES  86 H 2051  GLU SER PRO VAL ASP VAL GLN SER GLN VAL ASP SER SER
SEQRES  87 H 2051  SER VAL SER GLU ASP SER ALA VAL PHE LYS ALA THR SER
SEQRES  88 H 2051  SER THR ASP GLU GLU SER TRP PHE LYS ALA LEU ALA GLY
SEQRES  89 H 2051  SER GLU ILE ASN TRP ARG HIS ALA SER PHE LEU CYS SER
SEQRES  90 H 2051  PHE ILE THR GLN ASP LYS MET PHE VAL SER ASN PRO ILE
SEQRES  91 H 2051  ARG LYS VAL PHE LYS PRO SER GLN GLY MET VAL VAL GLU
SEQRES  92 H 2051  ILE SER ASN GLY ASN THR SER SER LYS THR VAL VAL THR
SEQRES  93 H 2051  LEU SER GLU PRO VAL GLN GLY GLU LEU LYS PRO THR VAL
SEQRES  94 H 2051  ILE LEU LYS LEU LEU LYS GLU ASN ILE ILE GLN MET GLU
SEQRES  95 H 2051  MET ILE GLU ASN ARG THR MET ASP GLY LYS PRO VAL SER
SEQRES  96 H 2051  LEU PRO LEU LEU TYR ASN PHE ASN PRO ASP ASN GLY PHE
SEQRES  97 H 2051  ALA PRO ILE SER GLU VAL MET GLU ASP ARG ASN GLN ARG
SEQRES  98 H 2051  ILE LYS GLU MET TYR TRP LYS LEU TRP ILE ASP GLU PRO
SEQRES  99 H 2051  PHE ASN LEU ASP PHE ASP PRO ARG ASP VAL ILE LYS GLY
SEQRES 100 H 2051  LYS ASP PHE GLU ILE THR ALA LYS GLU VAL TYR ASP PHE
SEQRES 101 H 2051  THR HIS ALA VAL GLY ASN ASN CYS GLU ASP PHE VAL SER
SEQRES 102 H 2051  ARG PRO ASP ARG THR MET LEU ALA PRO MET ASP PHE ALA
SEQRES 103 H 2051  ILE VAL VAL GLY TRP ARG ALA ILE ILE LYS ALA ILE PHE
SEQRES 104 H 2051  PRO ASN THR VAL ASP GLY ASP LEU LEU LYS LEU VAL HIS
SEQRES 105 H 2051  LEU SER ASN GLY TYR LYS MET ILE PRO GLY ALA LYS PRO
SEQRES 106 H 2051  LEU GLN VAL GLY ASP VAL VAL SER THR THR ALA VAL ILE
SEQRES 107 H 2051  GLU SER VAL VAL ASN GLN PRO THR GLY LYS ILE VAL ASP
SEQRES 108 H 2051  VAL VAL GLY THR LEU SER ARG ASN GLY LYS PRO VAL MET
SEQRES 109 H 2051  GLU VAL THR SER SER PHE PHE TYR ARG GLY ASN TYR THR
SEQRES 110 H 2051  ASP PHE GLU ASN THR PHE GLN LYS THR VAL GLU PRO VAL
SEQRES 111 H 2051  TYR GLN MET HIS ILE LYS THR SER LYS ASP ILE ALA VAL
SEQRES 112 H 2051  LEU ARG SER LYS GLU TRP PHE GLN LEU ASP ASP GLU ASP
SEQRES 113 H 2051  PHE ASP LEU LEU ASN LYS THR LEU THR PHE GLU THR GLU
SEQRES 114 H 2051  THR GLU VAL THR PHE LYS ASN ALA ASN ILE PHE SER SER
SEQRES 115 H 2051  VAL LYS CYS PHE GLY PRO ILE LYS VAL GLU LEU PRO THR
SEQRES 116 H 2051  LYS GLU THR VAL GLU ILE GLY ILE VAL ASP TYR GLU ALA
SEQRES 117 H 2051  GLY ALA SER HIS GLY ASN PRO VAL VAL ASP PHE LEU LYS
SEQRES 118 H 2051  ARG ASN GLY SER THR LEU GLU GLN LYS VAL ASN LEU GLU
SEQRES 119 H 2051  ASN PRO ILE PRO ILE ALA VAL LEU ASP SER TYR THR PRO
SEQRES 120 H 2051  SER THR ASN GLU PRO TYR ALA ARG VAL SER GLY ASP LEU
SEQRES 121 H 2051  ASN PRO ILE HIS VAL SER ARG HIS PHE ALA SER TYR ALA
SEQRES 122 H 2051  ASN LEU PRO GLY THR ILE THR HIS GLY MET PHE SER SER
SEQRES 123 H 2051  ALA SER VAL ARG ALA LEU ILE GLU ASN TRP ALA ALA ASP
SEQRES 124 H 2051  SER VAL SER SER ARG VAL ARG GLY TYR THR CYS GLN PHE
SEQRES 125 H 2051  VAL ASP MET VAL LEU PRO ASN THR ALA LEU LYS THR SER
SEQRES 126 H 2051  ILE GLN HIS VAL GLY MET ILE ASN GLY ARG LYS LEU ILE
SEQRES 127 H 2051  LYS PHE GLU THR ARG ASN GLU ASP ASP VAL VAL VAL LEU
SEQRES 128 H 2051  THR GLY GLU ALA GLU ILE GLU GLN PRO VAL THR THR PHE
SEQRES 129 H 2051  VAL PHE THR GLY GLN GLY SER GLN GLU GLN GLY MET GLY
SEQRES 130 H 2051  MET ASP LEU TYR LYS THR SER LYS ALA ALA GLN ASP VAL
SEQRES 131 H 2051  TRP ASN ARG ALA ASP ASN HIS PHE LYS ASP THR TYR GLY
SEQRES 132 H 2051  PHE SER ILE LEU ASP ILE VAL ILE ASN ASN PRO VAL ASN
SEQRES 133 H 2051  LEU THR ILE HIS PHE GLY GLY GLU LYS GLY LYS ARG ILE
SEQRES 134 H 2051  ARG GLU ASN TYR SER ALA MET ILE PHE GLU THR ILE VAL
SEQRES 135 H 2051  ASP GLY LYS LEU LYS THR GLU LYS ILE PHE LYS GLU ILE
SEQRES 136 H 2051  ASN GLU HIS SER THR SER TYR THR PHE ARG SER GLU LYS
SEQRES 137 H 2051  GLY LEU LEU SER ALA THR GLN PHE THR GLN PRO ALA LEU
SEQRES 138 H 2051  THR LEU MET GLU LYS ALA ALA PHE GLU ASP LEU LYS SER
SEQRES 139 H 2051  LYS GLY LEU ILE PRO ALA ASP ALA THR PHE ALA GLY HIS
SEQRES 140 H 2051  SER LEU GLY GLU TYR ALA ALA LEU ALA SER LEU ALA ASP
SEQRES 141 H 2051  VAL MET SER ILE GLU SER LEU VAL GLU VAL VAL PHE TYR
SEQRES 142 H 2051  ARG GLY MET THR MET GLN VAL ALA VAL PRO ARG ASP GLU
SEQRES 143 H 2051  LEU GLY ARG SER ASN TYR GLY MET ILE ALA ILE ASN PRO
SEQRES 144 H 2051  GLY ARG VAL ALA ALA SER PHE SER GLN GLU ALA LEU GLN
SEQRES 145 H 2051  TYR VAL VAL GLU ARG VAL GLY LYS ARG THR GLY TRP LEU
SEQRES 146 H 2051  VAL GLU ILE VAL ASN TYR ASN VAL GLU ASN GLN GLN TYR
SEQRES 147 H 2051  VAL ALA ALA GLY ASP LEU ARG ALA LEU ASP THR VAL THR
SEQRES 148 H 2051  ASN VAL LEU ASN PHE ILE LYS LEU GLN LYS ILE ASP ILE
SEQRES 149 H 2051  ILE GLU LEU GLN LYS SER LEU SER LEU GLU GLU VAL GLU
SEQRES 150 H 2051  GLY HIS LEU PHE GLU ILE ILE ASP GLU ALA SER LYS LYS
SEQRES 151 H 2051  SER ALA VAL LYS PRO ARG PRO LEU LYS LEU GLU ARG GLY
SEQRES 152 H 2051  PHE ALA CYS ILE PRO LEU VAL GLY ILE SER VAL PRO PHE
SEQRES 153 H 2051  HIS SER THR TYR LEU MET ASN GLY VAL LYS PRO PHE LYS
SEQRES 154 H 2051  SER PHE LEU LYS LYS ASN ILE ILE LYS GLU ASN VAL LYS
SEQRES 155 H 2051  VAL ALA ARG LEU ALA GLY LYS TYR ILE PRO ASN LEU THR
SEQRES 156 H 2051  ALA LYS PRO PHE GLN VAL THR LYS GLU TYR PHE GLN ASP
SEQRES 157 H 2051  VAL TYR ASP LEU THR GLY SER GLU PRO ILE LYS GLU ILE
SEQRES 158 H 2051  ILE ASP ASN TRP GLU LYS TYR GLU GLN SER
SEQRES   1 I 2051  MET ASP ALA TYR SER THR ARG PRO LEU THR LEU SER HIS
SEQRES   2 I 2051  GLY SER LEU GLU HIS VAL LEU LEU VAL PRO THR ALA SER
SEQRES   3 I 2051  PHE PHE ILE ALA SER GLN LEU GLN GLU GLN PHE ASN LYS
SEQRES   4 I 2051  ILE LEU PRO GLU PRO THR GLU GLY PHE ALA ALA ASP ASP
SEQRES   5 I 2051  GLU PRO THR THR PRO ALA GLU LEU VAL GLY LYS PHE LEU
SEQRES   6 I 2051  GLY TYR VAL SER SER LEU VAL GLU PRO SER LYS VAL GLY
SEQRES   7 I 2051  GLN PHE ASP GLN VAL LEU ASN LEU CYS LEU THR GLU PHE
SEQRES   8 I 2051  GLU ASN CYS TYR LEU GLU GLY ASN ASP ILE HIS ALA LEU
SEQRES   9 I 2051  ALA ALA LYS LEU LEU GLN GLU ASN ASP THR THR LEU VAL
SEQRES  10 I 2051  LYS THR LYS GLU LEU ILE LYS ASN TYR ILE THR ALA ARG
SEQRES  11 I 2051  ILE MET ALA LYS ARG PRO PHE ASP LYS LYS SER ASN SER
SEQRES  12 I 2051  ALA LEU PHE ARG ALA VAL GLY GLU GLY ASN ALA GLN LEU
SEQRES  13 I 2051  VAL ALA ILE PHE GLY GLY GLN GLY ASN THR ASP ASP TYR
SEQRES  14 I 2051  PHE GLU GLU LEU ARG ASP LEU TYR GLN THR TYR HIS VAL
SEQRES  15 I 2051  LEU VAL GLY ASP LEU ILE LYS PHE SER ALA GLU THR LEU
SEQRES  16 I 2051  SER GLU LEU ILE ARG THR THR LEU ASP ALA GLU LYS VAL
SEQRES  17 I 2051  PHE THR GLN GLY LEU ASN ILE LEU GLU TRP LEU GLU ASN
SEQRES  18 I 2051  PRO SER ASN THR PRO ASP LYS ASP TYR LEU LEU SER ILE
SEQRES  19 I 2051  PRO ILE SER CYS PRO LEU ILE GLY VAL ILE GLN LEU ALA
SEQRES  20 I 2051  HIS TYR VAL VAL THR ALA LYS LEU LEU GLY PHE THR PRO
SEQRES  21 I 2051  GLY GLU LEU ARG SER TYR LEU LYS GLY ALA THR GLY HIS
SEQRES  22 I 2051  SER GLN GLY LEU VAL THR ALA VAL ALA ILE ALA GLU THR
SEQRES  23 I 2051  ASP SER TRP GLU SER PHE PHE VAL SER VAL ARG LYS ALA
SEQRES  24 I 2051  ILE THR VAL LEU PHE PHE ILE GLY VAL ARG CYS TYR GLU
SEQRES  25 I 2051  ALA TYR PRO ASN THR SER LEU PRO PRO SER ILE LEU GLU
SEQRES  26 I 2051  ASP SER LEU GLU ASN ASN GLU GLY VAL PRO SER PRO MET
SEQRES  27 I 2051  LEU SER ILE SER ASN LEU THR GLN GLU GLN VAL GLN ASP
SEQRES  28 I 2051  TYR VAL ASN LYS THR ASN SER HIS LEU PRO ALA GLY LYS
SEQRES  29 I 2051  GLN VAL GLU ILE SER LEU VAL ASN GLY ALA LYS ASN LEU
SEQRES  30 I 2051  VAL VAL SER GLY PRO PRO GLN SER LEU TYR GLY LEU ASN
SEQRES  31 I 2051  LEU THR LEU ARG LYS ALA LYS ALA PRO SER GLY LEU ASP
SEQRES  32 I 2051  GLN SER ARG ILE PRO PHE SER GLU ARG LYS LEU LYS PHE
SEQRES  33 I 2051  SER ASN ARG PHE LEU PRO VAL ALA SER PRO PHE HIS SER
SEQRES  34 I 2051  HIS LEU LEU VAL PRO ALA SER ASP LEU ILE ASN LYS ASP
SEQRES  35 I 2051  LEU VAL LYS ASN ASN VAL SER PHE ASN ALA LYS ASP ILE
SEQRES  36 I 2051  GLN ILE PRO VAL TYR ASP THR PHE ASP GLY SER ASP LEU
SEQRES  37 I 2051  ARG VAL LEU SER GLY SER ILE SER GLU ARG ILE VAL ASP
SEQRES  38 I 2051  CYS ILE ILE ARG LEU PRO VAL LYS TRP GLU THR THR THR
SEQRES  39 I 2051  GLN PHE LYS ALA THR HIS ILE LEU ASP PHE GLY PRO GLY
SEQRES  40 I 2051  GLY ALA SER GLY LEU GLY VAL LEU THR HIS ARG ASN LYS
SEQRES  41 I 2051  ASP GLY THR GLY VAL ARG VAL ILE VAL ALA GLY THR LEU
SEQRES  42 I 2051  ASP ILE ASN PRO ASP ASP ASP TYR GLY PHE LYS GLN GLU
SEQRES  43 I 2051  ILE PHE ASP VAL THR SER ASN GLY LEU LYS LYS ASN PRO
SEQRES  44 I 2051  ASN TRP LEU GLU GLU TYR HIS PRO LYS LEU ILE LYS ASN
SEQRES  45 I 2051  LYS SER GLY LYS ILE PHE VAL GLU THR LYS PHE SER LYS
SEQRES  46 I 2051  LEU ILE GLY ARG PRO PRO LEU LEU VAL PRO GLY MET THR
SEQRES  47 I 2051  PRO CYS THR VAL SER PRO ASP PHE VAL ALA ALA THR THR
SEQRES  48 I 2051  ASN ALA GLY TYR THR ILE GLU LEU ALA GLY GLY GLY TYR
SEQRES  49 I 2051  PHE SER ALA ALA GLY MET THR ALA ALA ILE ASP SER VAL
SEQRES  50 I 2051  VAL SER GLN ILE GLU LYS GLY SER THR PHE GLY ILE ASN
SEQRES  51 I 2051  LEU ILE TYR VAL ASN PRO PHE MET LEU GLN TRP GLY ILE
SEQRES  52 I 2051  PRO LEU ILE LYS GLU LEU ARG SER LYS GLY TYR PRO ILE
SEQRES  53 I 2051  GLN PHE LEU THR ILE GLY ALA GLY VAL PRO SER LEU GLU
SEQRES  54 I 2051  VAL ALA SER GLU TYR ILE GLU THR LEU GLY LEU LYS TYR
SEQRES  55 I 2051  LEU GLY LEU LYS PRO GLY SER ILE ASP ALA ILE SER GLN
SEQRES  56 I 2051  VAL ILE ASN ILE ALA LYS ALA HIS PRO ASN PHE PRO ILE
SEQRES  57 I 2051  ALA LEU GLN TRP THR GLY GLY ARG GLY GLY GLY HIS HIS
SEQRES  58 I 2051  SER PHE GLU ASP ALA HIS THR PRO MET LEU GLN MET TYR
SEQRES  59 I 2051  SER LYS ILE ARG ARG HIS PRO ASN ILE MET LEU ILE PHE
SEQRES  60 I 2051  GLY SER GLY PHE GLY SER ALA ASP ASP THR TYR PRO TYR
SEQRES  61 I 2051  LEU THR GLY GLU TRP SER THR LYS PHE ASP TYR PRO PRO
SEQRES  62 I 2051  MET PRO PHE ASP GLY PHE LEU PHE GLY SER ARG VAL MET
SEQRES  63 I 2051  ILE ALA LYS GLU VAL LYS THR SER PRO ASP ALA LYS LYS
SEQRES  64 I 2051  CYS ILE ALA ALA CYS THR GLY VAL PRO ASP ASP LYS TRP
SEQRES  65 I 2051  GLU GLN THR TYR LYS LYS PRO THR GLY GLY ILE VAL THR
SEQRES  66 I 2051  VAL ARG SER GLU MET GLY GLU PRO ILE HIS LYS ILE ALA
SEQRES  67 I 2051  THR ARG GLY VAL MET LEU TRP LYS GLU PHE ASP GLU THR
SEQRES  68 I 2051  ILE PHE ASN LEU PRO LYS ASN LYS LEU VAL PRO THR LEU
SEQRES  69 I 2051  GLU ALA LYS ARG ASP TYR ILE ILE SER ARG LEU ASN ALA
SEQRES  70 I 2051  ASP PHE GLN LYS PRO TRP PHE ALA THR VAL ASN GLY GLN
SEQRES  71 I 2051  ALA ARG ASP LEU ALA THR MET THR TYR GLU GLU VAL ALA
SEQRES  72 I 2051  LYS ARG LEU VAL GLU LEU MET PHE ILE ARG SER THR ASN
SEQRES  73 I 2051  SER TRP PHE ASP VAL THR TRP ARG THR PHE THR GLY ASP
SEQRES  74 I 2051  PHE LEU ARG ARG VAL GLU GLU ARG PHE THR LYS SER LYS
SEQRES  75 I 2051  THR LEU SER LEU ILE GLN SER TYR SER LEU LEU ASP LYS
SEQRES  76 I 2051  PRO ASP GLU ALA ILE GLU LYS VAL PHE ASN ALA TYR PRO
SEQRES  77 I 2051  ALA ALA ARG GLU GLN PHE LEU ASN ALA GLN ASP ILE ASP
SEQRES  78 I 2051  HIS PHE LEU SER MET CYS GLN ASN PRO MET GLN LYS PRO
SEQRES  79 I 2051  VAL PRO PHE VAL PRO VAL LEU ASP ARG ARG PHE GLU ILE
SEQRES  80 I 2051  PHE PHE LYS LYS ASP SER LEU TRP GLN SER GLU HIS LEU
SEQRES  81 I 2051  GLU ALA VAL VAL ASP GLN ASP VAL GLN ARG THR CYS ILE
SEQRES  82 I 2051  LEU HIS GLY PRO VAL ALA ALA GLN PHE THR LYS VAL ILE
SEQRES  83 I 2051  ASP GLU PRO ILE LYS SER ILE MET ASP GLY ILE HIS ASP
SEQRES  84 I 2051  GLY HIS ILE LYS LYS LEU LEU HIS GLN TYR TYR GLY ASP
SEQRES  85 I 2051  ASP GLU SER LYS ILE PRO ALA VAL GLU TYR PHE GLY GLY
SEQRES  86 I 2051  GLU SER PRO VAL ASP VAL GLN SER GLN VAL ASP SER SER
SEQRES  87 I 2051  SER VAL SER GLU ASP SER ALA VAL PHE LYS ALA THR SER
SEQRES  88 I 2051  SER THR ASP GLU GLU SER TRP PHE LYS ALA LEU ALA GLY
SEQRES  89 I 2051  SER GLU ILE ASN TRP ARG HIS ALA SER PHE LEU CYS SER
SEQRES  90 I 2051  PHE ILE THR GLN ASP LYS MET PHE VAL SER ASN PRO ILE
SEQRES  91 I 2051  ARG LYS VAL PHE LYS PRO SER GLN GLY MET VAL VAL GLU
SEQRES  92 I 2051  ILE SER ASN GLY ASN THR SER SER LYS THR VAL VAL THR
SEQRES  93 I 2051  LEU SER GLU PRO VAL GLN GLY GLU LEU LYS PRO THR VAL
SEQRES  94 I 2051  ILE LEU LYS LEU LEU LYS GLU ASN ILE ILE GLN MET GLU
SEQRES  95 I 2051  MET ILE GLU ASN ARG THR MET ASP GLY LYS PRO VAL SER
SEQRES  96 I 2051  LEU PRO LEU LEU TYR ASN PHE ASN PRO ASP ASN GLY PHE
SEQRES  97 I 2051  ALA PRO ILE SER GLU VAL MET GLU ASP ARG ASN GLN ARG
SEQRES  98 I 2051  ILE LYS GLU MET TYR TRP LYS LEU TRP ILE ASP GLU PRO
SEQRES  99 I 2051  PHE ASN LEU ASP PHE ASP PRO ARG ASP VAL ILE LYS GLY
SEQRES 100 I 2051  LYS ASP PHE GLU ILE THR ALA LYS GLU VAL TYR ASP PHE
SEQRES 101 I 2051  THR HIS ALA VAL GLY ASN ASN CYS GLU ASP PHE VAL SER
SEQRES 102 I 2051  ARG PRO ASP ARG THR MET LEU ALA PRO MET ASP PHE ALA
SEQRES 103 I 2051  ILE VAL VAL GLY TRP ARG ALA ILE ILE LYS ALA ILE PHE
SEQRES 104 I 2051  PRO ASN THR VAL ASP GLY ASP LEU LEU LYS LEU VAL HIS
SEQRES 105 I 2051  LEU SER ASN GLY TYR LYS MET ILE PRO GLY ALA LYS PRO
SEQRES 106 I 2051  LEU GLN VAL GLY ASP VAL VAL SER THR THR ALA VAL ILE
SEQRES 107 I 2051  GLU SER VAL VAL ASN GLN PRO THR GLY LYS ILE VAL ASP
SEQRES 108 I 2051  VAL VAL GLY THR LEU SER ARG ASN GLY LYS PRO VAL MET
SEQRES 109 I 2051  GLU VAL THR SER SER PHE PHE TYR ARG GLY ASN TYR THR
SEQRES 110 I 2051  ASP PHE GLU ASN THR PHE GLN LYS THR VAL GLU PRO VAL
SEQRES 111 I 2051  TYR GLN MET HIS ILE LYS THR SER LYS ASP ILE ALA VAL
SEQRES 112 I 2051  LEU ARG SER LYS GLU TRP PHE GLN LEU ASP ASP GLU ASP
SEQRES 113 I 2051  PHE ASP LEU LEU ASN LYS THR LEU THR PHE GLU THR GLU
SEQRES 114 I 2051  THR GLU VAL THR PHE LYS ASN ALA ASN ILE PHE SER SER
SEQRES 115 I 2051  VAL LYS CYS PHE GLY PRO ILE LYS VAL GLU LEU PRO THR
SEQRES 116 I 2051  LYS GLU THR VAL GLU ILE GLY ILE VAL ASP TYR GLU ALA
SEQRES 117 I 2051  GLY ALA SER HIS GLY ASN PRO VAL VAL ASP PHE LEU LYS
SEQRES 118 I 2051  ARG ASN GLY SER THR LEU GLU GLN LYS VAL ASN LEU GLU
SEQRES 119 I 2051  ASN PRO ILE PRO ILE ALA VAL LEU ASP SER TYR THR PRO
SEQRES 120 I 2051  SER THR ASN GLU PRO TYR ALA ARG VAL SER GLY ASP LEU
SEQRES 121 I 2051  ASN PRO ILE HIS VAL SER ARG HIS PHE ALA SER TYR ALA
SEQRES 122 I 2051  ASN LEU PRO GLY THR ILE THR HIS GLY MET PHE SER SER
SEQRES 123 I 2051  ALA SER VAL ARG ALA LEU ILE GLU ASN TRP ALA ALA ASP
SEQRES 124 I 2051  SER VAL SER SER ARG VAL ARG GLY TYR THR CYS GLN PHE
SEQRES 125 I 2051  VAL ASP MET VAL LEU PRO ASN THR ALA LEU LYS THR SER
SEQRES 126 I 2051  ILE GLN HIS VAL GLY MET ILE ASN GLY ARG LYS LEU ILE
SEQRES 127 I 2051  LYS PHE GLU THR ARG ASN GLU ASP ASP VAL VAL VAL LEU
SEQRES 128 I 2051  THR GLY GLU ALA GLU ILE GLU GLN PRO VAL THR THR PHE
SEQRES 129 I 2051  VAL PHE THR GLY GLN GLY SER GLN GLU GLN GLY MET GLY
SEQRES 130 I 2051  MET ASP LEU TYR LYS THR SER LYS ALA ALA GLN ASP VAL
SEQRES 131 I 2051  TRP ASN ARG ALA ASP ASN HIS PHE LYS ASP THR TYR GLY
SEQRES 132 I 2051  PHE SER ILE LEU ASP ILE VAL ILE ASN ASN PRO VAL ASN
SEQRES 133 I 2051  LEU THR ILE HIS PHE GLY GLY GLU LYS GLY LYS ARG ILE
SEQRES 134 I 2051  ARG GLU ASN TYR SER ALA MET ILE PHE GLU THR ILE VAL
SEQRES 135 I 2051  ASP GLY LYS LEU LYS THR GLU LYS ILE PHE LYS GLU ILE
SEQRES 136 I 2051  ASN GLU HIS SER THR SER TYR THR PHE ARG SER GLU LYS
SEQRES 137 I 2051  GLY LEU LEU SER ALA THR GLN PHE THR GLN PRO ALA LEU
SEQRES 138 I 2051  THR LEU MET GLU LYS ALA ALA PHE GLU ASP LEU LYS SER
SEQRES 139 I 2051  LYS GLY LEU ILE PRO ALA ASP ALA THR PHE ALA GLY HIS
SEQRES 140 I 2051  SER LEU GLY GLU TYR ALA ALA LEU ALA SER LEU ALA ASP
SEQRES 141 I 2051  VAL MET SER ILE GLU SER LEU VAL GLU VAL VAL PHE TYR
SEQRES 142 I 2051  ARG GLY MET THR MET GLN VAL ALA VAL PRO ARG ASP GLU
SEQRES 143 I 2051  LEU GLY ARG SER ASN TYR GLY MET ILE ALA ILE ASN PRO
SEQRES 144 I 2051  GLY ARG VAL ALA ALA SER PHE SER GLN GLU ALA LEU GLN
SEQRES 145 I 2051  TYR VAL VAL GLU ARG VAL GLY LYS ARG THR GLY TRP LEU
SEQRES 146 I 2051  VAL GLU ILE VAL ASN TYR ASN VAL GLU ASN GLN GLN TYR
SEQRES 147 I 2051  VAL ALA ALA GLY ASP LEU ARG ALA LEU ASP THR VAL THR
SEQRES 148 I 2051  ASN VAL LEU ASN PHE ILE LYS LEU GLN LYS ILE ASP ILE
SEQRES 149 I 2051  ILE GLU LEU GLN LYS SER LEU SER LEU GLU GLU VAL GLU
SEQRES 150 I 2051  GLY HIS LEU PHE GLU ILE ILE ASP GLU ALA SER LYS LYS
SEQRES 151 I 2051  SER ALA VAL LYS PRO ARG PRO LEU LYS LEU GLU ARG GLY
SEQRES 152 I 2051  PHE ALA CYS ILE PRO LEU VAL GLY ILE SER VAL PRO PHE
SEQRES 153 I 2051  HIS SER THR TYR LEU MET ASN GLY VAL LYS PRO PHE LYS
SEQRES 154 I 2051  SER PHE LEU LYS LYS ASN ILE ILE LYS GLU ASN VAL LYS
SEQRES 155 I 2051  VAL ALA ARG LEU ALA GLY LYS TYR ILE PRO ASN LEU THR
SEQRES 156 I 2051  ALA LYS PRO PHE GLN VAL THR LYS GLU TYR PHE GLN ASP
SEQRES 157 I 2051  VAL TYR ASP LEU THR GLY SER GLU PRO ILE LYS GLU ILE
SEQRES 158 I 2051  ILE ASP ASN TRP GLU LYS TYR GLU GLN SER
MODRES 2UV8 GVL A  180  SER  SERINE MODIFED WITH PHOSPHOPANTETHEINE
MODRES 2UV8 GVL B  180  SER  SERINE MODIFED WITH PHOSPHOPANTETHEINE
MODRES 2UV8 GVL C  180  SER  SERINE MODIFED WITH PHOSPHOPANTETHEINE
HET    GVL  A 180      19
HET    GVL  B 180      19
HET    GVL  C 180      19
HET    FMN  G3051      31
HET    FMN  H3051      31
HET    FMN  I3051      31
HETNAM     GVL O-[(R)-{[(3R)-4-AMINO-3-HYDROXY-2,2-DIMETHYL-
HETNAM   2 GVL  4-OXOBUTYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE
HETNAM     FMN FLAVIN MONONUCLEOTIDE
HETSYN     FMN RIBOFLAVIN MONOPHOSPHATE
FORMUL   1  GVL    3(C9 H19 N2 O8 P)
FORMUL   7  FMN    3(C17 H21 N4 O9 P)
HELIX    1   1 PRO A    3  GLN A   21  1                                  19
HELIX    2   2 TRP A   28  LYS A   37  1                                  10
HELIX    3   3 THR A   52  LYS A   64  1                                  13
HELIX    4   4 GLU A   66  ALA A   71  1                                   6
HELIX    5   5 ALA A   85  ILE A   88  1                                   4
HELIX    6   6 ALA A  147  LEU A  159  1                                  13
HELIX    7   7 ILE A  172  VAL A  176  1                                   5
HELIX    8   8 THR A  181  PHE A  194  1                                  14
HELIX    9   9 LEU A  206  THR A  216  1                                  11
HELIX   10  10 LYS A  223  LYS A  236  1                                  14
HELIX   11  11 ILE A  243  THR A  252  1                                  10
HELIX   12  12 SER A  258  ALA A  268  1                                  11
HELIX   13  13 GLU A  280  VAL A  298  1                                  19
HELIX   14  14 GLU A  329  LEU A  350  1                                  22
HELIX   15  15 ASN A  356  LEU A  382  1                                  27
HELIX   16  16 GLU A  384  GLY A  389  1                                   6
HELIX   17  17 ARG A  396  LYS A  398  1                                   3
HELIX   18  18 SER A  405  ILE A  421  1                                  17
HELIX   19  19 ARG A  430  MET A  440  1                                  11
HELIX   20  20 ASP A  445  SER A  456  1                                  12
HELIX   21  21 GLU A  460  LYS A  462  1                                   3
HELIX   22  22 GLU A  464  VAL A  483  1                                  20
HELIX   23  23 LEU A  522  LEU A  531  1                                  10
HELIX   24  24 SER A  609  SER A  615  1                                   7
HELIX   25  25 VAL A  626  THR A  629  1                                   4
HELIX   26  26 ARG A  653  ASN A  669  1                                  17
HELIX   27  27 ILE A  688  GLN A  698  1                                  11
HELIX   28  28 LYS A  712  TYR A  725  1                                  14
HELIX   29  29 LYS A  742  TYR A  753  1                                  12
HELIX   30  30 LEU A  781  HIS A  783  1                                   3
HELIX   31  31 SER A  786  MET A  795  1                                  10
HELIX   32  32 THR A  797  ALA A  812  1                                  16
HELIX   33  33 TYR A  839  SER A  855  1                                  17
HELIX   34  34 ALA A  885  GLU A  889  1                                   5
HELIX   35  35 GLN A  898  LEU A  909  1                                  12
HELIX   36  36 PRO A  911  LYS A  919  1                                   9
HELIX   37  37 LEU A  930  PHE A  932  1                                   3
HELIX   38  38 LEU A  936  ASN A  969  1                                  34
HELIX   39  39 ASN A  971  ALA A  975  1                                   5
HELIX   40  40 TYR A  998  ILE A 1004  1                                   7
HELIX   41  41 ALA A 1007  LEU A 1009  1                                   3
HELIX   42  42 LEU A 1015  ARG A 1017  1                                   3
HELIX   43  43 ALA A 1033  PHE A 1042  1                                  10
HELIX   44  44 LEU A 1047  ILE A 1056  1                                  10
HELIX   45  45 ASP A 1086  GLU A 1099  1                                  14
HELIX   46  46 PRO A 1108  PHE A 1111  1                                   4
HELIX   47  47 LYS A 1138  LYS A 1151  1                                  14
HELIX   48  48 ASP A 1202  GLN A 1207  1                                   6
HELIX   49  49 PRO A 1210  ALA A 1225  1                                  16
HELIX   50  50 PRO A 1231  TYR A 1237  1                                   7
HELIX   51  51 VAL A 1240  GLU A 1242  1                                   3
HELIX   52  52 VAL A 1254  PHE A 1261  1                                   8
HELIX   53  53 ILE A 1274  SER A 1278  1                                   5
HELIX   54  54 THR A 1282  LEU A 1290  1                                   9
HELIX   55  55 ALA A 1304  LEU A 1320  1                                  17
HELIX   56  56 GLU A 1337  ASN A 1345  1                                   9
HELIX   57  57 THR A 1352  GLU A 1357  1                                   6
HELIX   58  58 PRO A 1362  GLU A 1364  1                                   3
HELIX   59  59 ALA A 1390  MET A 1396  1                                   7
HELIX   60  60 GLY A 1424  ALA A 1429  1                                   6
HELIX   61  61 PRO A 1441  LEU A 1443  1                                   3
HELIX   62  62 MET A 1445  ALA A 1474  1                                  30
HELIX   63  63 GLN A 1482  TRP A 1508  1                                  27
HELIX   64  64 PRO A 1521  ALA A 1527  1                                   7
HELIX   65  65 ILE A 1533  ASP A 1535  1                                   3
HELIX   66  66 LYS A 1547  LEU A 1564  1                                  18
HELIX   67  67 LYS A 1578  THR A 1581  1                                   4
HELIX   68  68 ALA A 1588  LEU A 1600  1                                  13
HELIX   69  69 LYS A 1616  GLN A 1620  1                                   5
HELIX   70  70 ASP A 1659  TYR A 1662  1                                   4
HELIX   71  71 GLU A 1667  TYR A 1694  1                                  28
HELIX   72  72 ASP A 1708  LEU A 1716  1                                   9
HELIX   73  73 SER A 1735  ASN A 1737  1                                   3
HELIX   74  74 LYS A 1741  ASN A 1746  1                                   6
HELIX   75   1 PHE G   27  ILE G   40  1                                  14
HELIX   76   2 PRO G   57  SER G   69  1                                  13
HELIX   77   3 ASP G   81  TYR G   95  1                                  15
HELIX   78   4 ILE G  101  GLN G  110  1                                  10
HELIX   79   5 LEU G  116  MET G  132  1                                  17
HELIX   80   6 ALA G  144  GLU G  151  1                                   8
HELIX   81   7 TYR G  169  THR G  179  1                                  11
HELIX   82   8 HIS G  181  THR G  201  1                                  21
HELIX   83   9 ALA G  205  VAL G  208  1                                   4
HELIX   84  10 ILE G  215  GLU G  220  1                                   6
HELIX   85  11 PRO G  222  ASN G  224  1                                   3
HELIX   86  12 LYS G  228  LEU G  232  1                                   5
HELIX   87  13 ILE G  234  LEU G  256  1                                  23
HELIX   88  14 PRO G  260  SER G  265  1                                   6
HELIX   89  15 GLY G  276  ALA G  284  1                                   9
HELIX   90  16 TRP G  289  ALA G  313  1                                  25
HELIX   91  17 PRO G  321  LEU G  328  1                                   8
HELIX   92  18 GLN G  346  SER G  358  1                                  13
HELIX   93  19 ALA G  362  LYS G  364  1                                   3
HELIX   94  20 PRO G  383  ALA G  396  1                                  14
HELIX   95  21 PHE G  409  GLU G  411  1                                   3
HELIX   96  22 VAL G  433  VAL G  444  1                                  12
HELIX   97  23 ILE G  475  ILE G  484  1                                  10
HELIX   98  24 THR G  492  THR G  494  1                                   3
HELIX   99  25 GLY G  508  SER G  510  1                                   3
HELIX  100  26 LEU G  512  LYS G  520  1                                   9
HELIX  101  27 LYS G  544  ILE G  547  1                                   4
HELIX  102  28 SER G  552  GLY G  554  1                                   3
HELIX  103  29 TRP G  561  GLU G  564  1                                   4
HELIX  104  30 SER G  584  ILE G  587  1                                   4
HELIX  105  31 THR G  598  VAL G  602  1                                   5
HELIX  106  32 PRO G  604  ASN G  612  1                                   9
HELIX  107  33 GLY G  621  GLY G  623  1                                   3
HELIX  108  34 ALA G  627  GLN G  640  1                                  14
HELIX  109  35 MET G  658  SER G  671  1                                  14
HELIX  110  36 LEU G  688  THR G  697  1                                  10
HELIX  111  37 ILE G  710  ALA G  722  1                                  13
HELIX  112  38 THR G  748  ILE G  757  1                                  10
HELIX  113  39 ALA G  774  THR G  777  1                                   4
HELIX  114  40 PRO G  779  THR G  782  1                                   4
HELIX  115  41 TRP G  785  PHE G  789  1                                   5
HELIX  116  42 ARG G  804  ILE G  807  1                                   4
HELIX  117  43 PRO G  815  ALA G  823  1                                   9
HELIX  118  44 ASP G  829  TYR G  836  1                                   8
HELIX  119  45 ARG G  860  THR G  871  1                                  12
HELIX  120  46 LEU G  880  GLU G  885  1                                   6
HELIX  121  47 ARG G  888  ASP G  898  1                                  11
HELIX  122  48 LEU G  914  THR G  916  1                                   3
HELIX  123  49 TYR G  919  MET G  930  1                                  12
HELIX  124  50 ARG G  933  THR G  935  1                                   3
HELIX  125  51 VAL G  941  PHE G  958  1                                  18
HELIX  126  52 TYR G  970  ASP G  974  1                                   5
HELIX  127  53 PRO G  976  ALA G  986  1                                  11
HELIX  128  54 PRO G  988  ARG G  991  1                                   4
HELIX  129  55 ALA G  997  MET G 1006  1                                  10
HELIX  130  56 PHE G 1025  LYS G 1030  1                                   6
HELIX  131  57 TRP G 1035  GLU G 1038  1                                   4
HELIX  132  58 LEU G 1040  ALA G 1042  1                                   3
HELIX  133  59 VAL G 1048  ARG G 1050  1                                   3
HELIX  134  60 ILE G 1070  TYR G 1090  1                                  21
HELIX  135  61 GLU G 1094  LYS G 1096  1                                   3
HELIX  136  62 GLU G 1135  ALA G 1143  1                                   9
HELIX  137  63 TRP G 1149  LEU G 1155  1                                   7
HELIX  138  64 PRO G 1169  VAL G 1173  1                                   5
HELIX  139  65 SER G 1190  LYS G 1192  1                                   3
HELIX  140  66 ARG G 1258  TRP G 1270  1                                  13
HELIX  141  67 ALA G 1294  VAL G 1304  1                                  11
HELIX  142  68 GLU G 1309  PHE G 1311  1                                   3
HELIX  143  69 MET G 1323  ILE G 1338  1                                  16
HELIX  144  70 LEU G 1347  LYS G 1349  1                                   3
HELIX  145  71 PHE G 1419  ASN G 1421  1                                   3
HELIX  146  72 SER G 1438  SER G 1446  1                                   9
HELIX  147  73 PRO G 1515  ASN G 1523  1                                   9
HELIX  148  74 GLU G 1551  SER G 1557  1                                   7
HELIX  149  75 PRO G 1562  HIS G 1564  1                                   3
HELIX  150  76 ARG G 1567  ALA G 1573  1                                   7
HELIX  151  77 GLY G 1582  ALA G 1597  1                                  16
HELIX  152  78 SER G 1602  ARG G 1604  1                                   3
HELIX  153  79 MET G 1678  THR G 1683  1                                   6
HELIX  154  80 LYS G 1685  TYR G 1702  1                                  18
HELIX  155  81 ILE G 1706  ILE G 1711  1                                   6
HELIX  156  82 GLU G 1724  SER G 1734  1                                  11
HELIX  157  83 LEU G 1770  SER G 1772  1                                   3
HELIX  158  84 THR G 1774  LYS G 1795  1                                  22
HELIX  159  85 GLY G 1810  ALA G 1819  1                                  10
HELIX  160  86 ILE G 1824  VAL G 1840  1                                  17
HELIX  161  87 PRO G 1859  VAL G 1862  1                                   4
HELIX  162  88 GLN G 1868  THR G 1882  1                                  15
HELIX  163  89 LEU G 1904  GLN G 1920  1                                  17
HELIX  164  90 ILE G 1924  SER G 1930  1                                   7
HELIX  165  91 LEU G 1933  ALA G 1952  1                                  20
HELIX  166  92 THR G 1979  LEU G 1981  1                                   3
HELIX  167  93 VAL G 1985  ASN G 1995  1                                  11
HELIX  168  94 LYS G 1998  ASN G 2000  1                                   3
HELIX  169  95 VAL G 2003  LEU G 2006  1                                   4
HELIX  170  96 LYS G 2023  THR G 2033  1                                  11
HELIX  171  97 GLU G 2036  ASP G 2043  1                                   8
HELIX  172   1 PRO B    3  GLN B   21  1                                  19
HELIX  173   2 TRP B   28  LYS B   37  1                                  10
HELIX  174   3 THR B   52  LYS B   64  1                                  13
HELIX  175   4 GLU B   66  ALA B   71  1                                   6
HELIX  176   5 ALA B   85  ILE B   88  1                                   4
HELIX  177   6 ALA B  147  LEU B  159  1                                  13
HELIX  178   7 ILE B  172  VAL B  176  1                                   5
HELIX  179   8 THR B  181  PHE B  194  1                                  14
HELIX  180   9 LEU B  206  THR B  216  1                                  11
HELIX  181  10 LYS B  223  LYS B  236  1                                  14
HELIX  182  11 ILE B  243  THR B  252  1                                  10
HELIX  183  12 SER B  258  ALA B  268  1                                  11
HELIX  184  13 GLU B  280  VAL B  298  1                                  19
HELIX  185  14 GLU B  329  LEU B  350  1                                  22
HELIX  186  15 ASN B  356  LEU B  382  1                                  27
HELIX  187  16 GLU B  384  GLY B  389  1                                   6
HELIX  188  17 ARG B  396  LYS B  398  1                                   3
HELIX  189  18 SER B  405  ILE B  421  1                                  17
HELIX  190  19 ARG B  430  MET B  440  1                                  11
HELIX  191  20 ASP B  445  SER B  456  1                                  12
HELIX  192  21 GLU B  460  LYS B  462  1                                   3
HELIX  193  22 GLU B  464  VAL B  483  1                                  20
HELIX  194  23 LEU B  522  LEU B  531  1                                  10
HELIX  195  24 SER B  609  SER B  615  1                                   7
HELIX  196  25 VAL B  626  THR B  629  1                                   4
HELIX  197  26 ARG B  653  ASN B  669  1                                  17
HELIX  198  27 ILE B  688  GLN B  698  1                                  11
HELIX  199  28 LYS B  712  TYR B  725  1                                  14
HELIX  200  29 LYS B  742  TYR B  753  1                                  12
HELIX  201  30 LEU B  781  HIS B  783  1                                   3
HELIX  202  31 SER B  786  MET B  795  1                                  10
HELIX  203  32 THR B  797  ALA B  812  1                                  16
HELIX  204  33 TYR B  839  SER B  855  1                                  17
HELIX  205  34 ALA B  885  GLU B  889  1                                   5
HELIX  206  35 GLN B  898  LEU B  909  1                                  12
HELIX  207  36 PRO B  911  LYS B  919  1                                   9
HELIX  208  37 LEU B  930  PHE B  932  1                                   3
HELIX  209  38 LEU B  936  ASN B  969  1                                  34
HELIX  210  39 ASN B  971  ALA B  975  1                                   5
HELIX  211  40 TYR B  998  ILE B 1004  1                                   7
HELIX  212  41 ALA B 1007  LEU B 1009  1                                   3
HELIX  213  42 LEU B 1015  ARG B 1017  1                                   3
HELIX  214  43 ALA B 1033  PHE B 1042  1                                  10
HELIX  215  44 LEU B 1047  ILE B 1056  1                                  10
HELIX  216  45 ASP B 1086  GLU B 1099  1                                  14
HELIX  217  46 PRO B 1108  PHE B 1111  1                                   4
HELIX  218  47 LYS B 1138  LYS B 1151  1                                  14
HELIX  219  48 ASP B 1202  GLN B 1207  1                                   6
HELIX  220  49 PRO B 1210  ALA B 1225  1                                  16
HELIX  221  50 PRO B 1231  TYR B 1237  1                                   7
HELIX  222  51 VAL B 1240  GLU B 1242  1                                   3
HELIX  223  52 VAL B 1254  PHE B 1261  1                                   8
HELIX  224  53 ILE B 1274  SER B 1278  1                                   5
HELIX  225  54 THR B 1282  LEU B 1290  1                                   9
HELIX  226  55 ALA B 1304  LEU B 1320  1                                  17
HELIX  227  56 GLU B 1337  ASN B 1345  1                                   9
HELIX  228  57 THR B 1352  GLU B 1357  1                                   6
HELIX  229  58 PRO B 1362  GLU B 1364  1                                   3
HELIX  230  59 ALA B 1390  MET B 1396  1                                   7
HELIX  231  60 GLY B 1424  ALA B 1429  1                                   6
HELIX  232  61 PRO B 1441  LEU B 1443  1                                   3
HELIX  233  62 MET B 1445  ALA B 1474  1                                  30
HELIX  234  63 ASN B 1483  TRP B 1508  1                                  26
HELIX  235  64 PRO B 1521  ALA B 1527  1                                   7
HELIX  236  65 ILE B 1533  ASP B 1535  1                                   3
HELIX  237  66 LYS B 1547  LEU B 1564  1                                  18
HELIX  238  67 LYS B 1578  THR B 1581  1                                   4
HELIX  239  68 ALA B 1588  LEU B 1600  1                                  13
HELIX  240  69 LYS B 1616  GLN B 1620  1                                   5
HELIX  241  70 ASP B 1659  TYR B 1662  1                                   4
HELIX  242  71 GLU B 1667  TYR B 1694  1                                  28
HELIX  243  72 ASP B 1708  LEU B 1716  1                                   9
HELIX  244  73 SER B 1735  ASN B 1737  1                                   3
HELIX  245  74 LYS B 1741  ASN B 1746  1                                   6
HELIX  246   1 PHE H   27  ILE H   40  1                                  14
HELIX  247   2 PRO H   57  SER H   69  1                                  13
HELIX  248   3 ASP H   81  TYR H   95  1                                  15
HELIX  249   4 ILE H  101  GLN H  110  1                                  10
HELIX  250   5 LEU H  116  MET H  132  1                                  17
HELIX  251   6 ALA H  144  GLU H  151  1                                   8
HELIX  252   7 TYR H  169  THR H  179  1                                  11
HELIX  253   8 HIS H  181  THR H  201  1                                  21
HELIX  254   9 ALA H  205  VAL H  208  1                                   4
HELIX  255  10 ILE H  215  GLU H  220  1                                   6
HELIX  256  11 PRO H  222  ASN H  224  1                                   3
HELIX  257  12 LYS H  228  LEU H  232  1                                   5
HELIX  258  13 ILE H  234  LEU H  256  1                                  23
HELIX  259  14 PRO H  260  SER H  265  1                                   6
HELIX  260  15 GLY H  276  ALA H  284  1                                   9
HELIX  261  16 TRP H  289  ALA H  313  1                                  25
HELIX  262  17 PRO H  321  LEU H  328  1                                   8
HELIX  263  18 GLN H  346  SER H  358  1                                  13
HELIX  264  19 ALA H  362  LYS H  364  1                                   3
HELIX  265  20 PRO H  383  ALA H  396  1                                  14
HELIX  266  21 PHE H  409  GLU H  411  1                                   3
HELIX  267  22 VAL H  433  VAL H  444  1                                  12
HELIX  268  23 ILE H  475  ILE H  484  1                                  10
HELIX  269  24 THR H  492  THR H  494  1                                   3
HELIX  270  25 GLY H  508  SER H  510  1                                   3
HELIX  271  26 LEU H  512  LYS H  520  1                                   9
HELIX  272  27 LYS H  544  ILE H  547  1                                   4
HELIX  273  28 SER H  552  GLY H  554  1                                   3
HELIX  274  29 TRP H  561  GLU H  564  1                                   4
HELIX  275  30 SER H  584  ILE H  587  1                                   4
HELIX  276  31 THR H  598  VAL H  602  1                                   5
HELIX  277  32 PRO H  604  ASN H  612  1                                   9
HELIX  278  33 GLY H  621  GLY H  623  1                                   3
HELIX  279  34 ALA H  627  GLN H  640  1                                  14
HELIX  280  35 MET H  658  SER H  671  1                                  14
HELIX  281  36 LEU H  688  THR H  697  1                                  10
HELIX  282  37 ILE H  710  ALA H  722  1                                  13
HELIX  283  38 THR H  748  ILE H  757  1                                  10
HELIX  284  39 ALA H  774  THR H  777  1                                   4
HELIX  285  40 PRO H  779  THR H  782  1                                   4
HELIX  286  41 TRP H  785  PHE H  789  1                                   5
HELIX  287  42 ARG H  804  ILE H  807  1                                   4
HELIX  288  43 PRO H  815  ALA H  823  1                                   9
HELIX  289  44 ASP H  829  TYR H  836  1                                   8
HELIX  290  45 ARG H  860  THR H  871  1                                  12
HELIX  291  46 LEU H  880  GLU H  885  1                                   6
HELIX  292  47 ARG H  888  ASP H  898  1                                  11
HELIX  293  48 LEU H  914  THR H  916  1                                   3
HELIX  294  49 TYR H  919  MET H  930  1                                  12
HELIX  295  50 ARG H  933  THR H  935  1                                   3
HELIX  296  51 VAL H  941  PHE H  958  1                                  18
HELIX  297  52 TYR H  970  ASP H  974  1                                   5
HELIX  298  53 PRO H  976  ALA H  986  1                                  11
HELIX  299  54 PRO H  988  ARG H  991  1                                   4
HELIX  300  55 ALA H  997  MET H 1006  1                                  10
HELIX  301  56 PHE H 1025  LYS H 1030  1                                   6
HELIX  302  57 TRP H 1035  GLU H 1038  1                                   4
HELIX  303  58 LEU H 1040  ALA H 1042  1                                   3
HELIX  304  59 VAL H 1048  ARG H 1050  1                                   3
HELIX  305  60 ILE H 1070  TYR H 1090  1                                  21
HELIX  306  61 GLU H 1094  LYS H 1096  1                                   3
HELIX  307  62 GLU H 1135  ALA H 1143  1                                   9
HELIX  308  63 TRP H 1149  LEU H 1155  1                                   7
HELIX  309  64 PRO H 1169  VAL H 1173  1                                   5
HELIX  310  65 SER H 1190  LYS H 1192  1                                   3
HELIX  311  66 ARG H 1258  TRP H 1270  1                                  13
HELIX  312  67 ALA H 1294  VAL H 1304  1                                  11
HELIX  313  68 GLU H 1309  PHE H 1311  1                                   3
HELIX  314  69 MET H 1323  ILE H 1338  1                                  16
HELIX  315  70 LEU H 1347  LYS H 1349  1                                   3
HELIX  316  71 PHE H 1419  ASN H 1421  1                                   3
HELIX  317  72 SER H 1438  SER H 1446  1                                   9
HELIX  318  73 PRO H 1515  ASN H 1523  1                                   9
HELIX  319  74 GLU H 1551  SER H 1557  1                                   7
HELIX  320  75 PRO H 1562  HIS H 1564  1                                   3
HELIX  321  76 ARG H 1567  ALA H 1573  1                                   7
HELIX  322  77 GLY H 1582  ALA H 1597  1                                  16
HELIX  323  78 SER H 1602  ARG H 1604  1                                   3
HELIX  324  79 MET H 1678  THR H 1683  1                                   6
HELIX  325  80 LYS H 1685  TYR H 1702  1                                  18
HELIX  326  81 ILE H 1706  ILE H 1711  1                                   6
HELIX  327  82 GLU H 1724  SER H 1734  1                                  11
HELIX  328  83 LEU H 1770  SER H 1772  1                                   3
HELIX  329  84 THR H 1774  LYS H 1795  1                                  22
HELIX  330  85 GLY H 1810  ALA H 1819  1                                  10
HELIX  331  86 ILE H 1824  VAL H 1840  1                                  17
HELIX  332  87 PRO H 1859  VAL H 1862  1                                   4
HELIX  333  88 GLN H 1868  THR H 1882  1                                  15
HELIX  334  89 LEU H 1904  GLN H 1920  1                                  17
HELIX  335  90 ILE H 1924  SER H 1930  1                                   7
HELIX  336  91 LEU H 1933  ALA H 1952  1                                  20
HELIX  337  92 THR H 1979  LEU H 1981  1                                   3
HELIX  338  93 VAL H 1985  ASN H 1995  1                                  11
HELIX  339  94 LYS H 1998  ASN H 2000  1                                   3
HELIX  340  95 VAL H 2003  LEU H 2006  1                                   4
HELIX  341  96 LYS H 2023  THR H 2033  1                                  11
HELIX  342  97 GLU H 2036  ASP H 2043  1                                   8
HELIX  343   1 PRO C    3  GLN C   21  1                                  19
HELIX  344   2 TRP C   28  LYS C   37  1                                  10
HELIX  345   3 THR C   52  LYS C   64  1                                  13
HELIX  346   4 GLU C   66  ALA C   71  1                                   6
HELIX  347   5 ALA C   85  ILE C   88  1                                   4
HELIX  348   6 ALA C  147  LEU C  159  1                                  13
HELIX  349   7 ILE C  172  VAL C  176  1                                   5
HELIX  350   8 THR C  181  PHE C  194  1                                  14
HELIX  351   9 LEU C  206  THR C  216  1                                  11
HELIX  352  10 LYS C  223  LYS C  236  1                                  14
HELIX  353  11 ILE C  243  THR C  252  1                                  10
HELIX  354  12 SER C  258  ALA C  268  1                                  11
HELIX  355  13 GLU C  280  VAL C  298  1                                  19
HELIX  356  14 GLU C  329  LEU C  350  1                                  22
HELIX  357  15 ASN C  356  LEU C  382  1                                  27
HELIX  358  16 GLU C  384  GLY C  389  1                                   6
HELIX  359  17 ARG C  396  LYS C  398  1                                   3
HELIX  360  18 SER C  405  ILE C  421  1                                  17
HELIX  361  19 ARG C  430  MET C  440  1                                  11
HELIX  362  20 ASP C  445  SER C  456  1                                  12
HELIX  363  21 GLU C  460  LYS C  462  1                                   3
HELIX  364  22 GLU C  464  VAL C  483  1                                  20
HELIX  365  23 LEU C  522  LEU C  531  1                                  10
HELIX  366  24 SER C  609  SER C  615  1                                   7
HELIX  367  25 VAL C  626  THR C  629  1                                   4
HELIX  368  26 ARG C  653  ASN C  669  1                                  17
HELIX  369  27 ILE C  688  GLN C  698  1                                  11
HELIX  370  28 LYS C  712  TYR C  725  1                                  14
HELIX  371  29 LYS C  742  TYR C  753  1                                  12
HELIX  372  30 LEU C  781  HIS C  783  1                                   3
HELIX  373  31 SER C  786  MET C  795  1                                  10
HELIX  374  32 THR C  797  ALA C  812  1                                  16
HELIX  375  33 TYR C  839  SER C  855  1                                  17
HELIX  376  34 ALA C  885  GLU C  889  1                                   5
HELIX  377  35 GLN C  898  LEU C  909  1                                  12
HELIX  378  36 PRO C  911  LYS C  919  1                                   9
HELIX  379  37 LEU C  930  PHE C  932  1                                   3
HELIX  380  38 LEU C  936  ASN C  969  1                                  34
HELIX  381  39 ASN C  971  ALA C  975  1                                   5
HELIX  382  40 TYR C  998  ILE C 1004  1                                   7
HELIX  383  41 ALA C 1007  LEU C 1009  1                                   3
HELIX  384  42 LEU C 1015  ARG C 1017  1                                   3
HELIX  385  43 ALA C 1033  PHE C 1042  1                                  10
HELIX  386  44 LEU C 1047  ILE C 1056  1                                  10
HELIX  387  45 ASP C 1086  GLU C 1099  1                                  14
HELIX  388  46 PRO C 1108  PHE C 1111  1                                   4
HELIX  389  47 LYS C 1138  LYS C 1151  1                                  14
HELIX  390  48 ASP C 1202  GLN C 1207  1                                   6
HELIX  391  49 PRO C 1210  ALA C 1225  1                                  16
HELIX  392  50 PRO C 1231  TYR C 1237  1                                   7
HELIX  393  51 VAL C 1240  GLU C 1242  1                                   3
HELIX  394  52 VAL C 1254  PHE C 1261  1                                   8
HELIX  395  53 ILE C 1274  SER C 1278  1                                   5
HELIX  396  54 THR C 1282  LEU C 1290  1                                   9
HELIX  397  55 ALA C 1304  LEU C 1320  1                                  17
HELIX  398  56 GLU C 1337  ASN C 1345  1                                   9
HELIX  399  57 THR C 1352  GLU C 1357  1                                   6
HELIX  400  58 PRO C 1362  GLU C 1364  1                                   3
HELIX  401  59 ALA C 1390  MET C 1396  1                                   7
HELIX  402  60 GLY C 1424  ALA C 1429  1                                   6
HELIX  403  61 PRO C 1441  LEU C 1443  1                                   3
HELIX  404  62 MET C 1445  ALA C 1474  1                                  30
HELIX  405  63 GLN C 1482  TRP C 1508  1                                  27
HELIX  406  64 PRO C 1521  ALA C 1527  1                                   7
HELIX  407  65 ILE C 1533  ASP C 1535  1                                   3
HELIX  408  66 LYS C 1547  LEU C 1564  1                                  18
HELIX  409  67 LYS C 1578  THR C 1581  1                                   4
HELIX  410  68 ALA C 1588  LEU C 1600  1                                  13
HELIX  411  69 LYS C 1616  GLN C 1620  1                                   5
HELIX  412  70 ASP C 1659  TYR C 1662  1                                   4
HELIX  413  71 GLU C 1667  TYR C 1694  1                                  28
HELIX  414  72 ASP C 1708  LEU C 1716  1                                   9
HELIX  415  73 SER C 1735  ASN C 1737  1                                   3
HELIX  416  74 LYS C 1741  ASN C 1746  1                                   6
HELIX  417   1 PHE I   27  ILE I   40  1                                  14
HELIX  418   2 PRO I   57  SER I   69  1                                  13
HELIX  419   3 ASP I   81  TYR I   95  1                                  15
HELIX  420   4 ILE I  101  GLN I  110  1                                  10
HELIX  421   5 LEU I  116  MET I  132  1                                  17
HELIX  422   6 ALA I  144  GLU I  151  1                                   8
HELIX  423   7 TYR I  169  THR I  179  1                                  11
HELIX  424   8 HIS I  181  THR I  201  1                                  21
HELIX  425   9 ALA I  205  VAL I  208  1                                   4
HELIX  426  10 ILE I  215  GLU I  220  1                                   6
HELIX  427  11 PRO I  222  ASN I  224  1                                   3
HELIX  428  12 LYS I  228  LEU I  232  1                                   5
HELIX  429  13 ILE I  234  LEU I  256  1                                  23
HELIX  430  14 PRO I  260  SER I  265  1                                   6
HELIX  431  15 GLY I  276  ALA I  284  1                                   9
HELIX  432  16 TRP I  289  ALA I  313  1                                  25
HELIX  433  17 PRO I  321  LEU I  328  1                                   8
HELIX  434  18 GLN I  346  SER I  358  1                                  13
HELIX  435  19 ALA I  362  LYS I  364  1                                   3
HELIX  436  20 PRO I  383  ALA I  396  1                                  14
HELIX  437  21 PHE I  409  GLU I  411  1                                   3
HELIX  438  22 VAL I  433  VAL I  444  1                                  12
HELIX  439  23 ILE I  475  ILE I  484  1                                  10
HELIX  440  24 THR I  492  THR I  494  1                                   3
HELIX  441  25 GLY I  508  SER I  510  1                                   3
HELIX  442  26 LEU I  512  LYS I  520  1                                   9
HELIX  443  27 LYS I  544  ILE I  547  1                                   4
HELIX  444  28 SER I  552  GLY I  554  1                                   3
HELIX  445  29 TRP I  561  GLU I  564  1                                   4
HELIX  446  30 SER I  584  ILE I  587  1                                   4
HELIX  447  31 THR I  598  VAL I  602  1                                   5
HELIX  448  32 PRO I  604  ASN I  612  1                                   9
HELIX  449  33 GLY I  621  GLY I  623  1                                   3
HELIX  450  34 ALA I  627  GLN I  640  1                                  14
HELIX  451  35 MET I  658  SER I  671  1                                  14
HELIX  452  36 LEU I  688  THR I  697  1                                  10
HELIX  453  37 ILE I  710  ALA I  722  1                                  13
HELIX  454  38 THR I  748  ILE I  757  1                                  10
HELIX  455  39 ALA I  774  THR I  777  1                                   4
HELIX  456  40 PRO I  779  THR I  782  1                                   4
HELIX  457  41 TRP I  785  PHE I  789  1                                   5
HELIX  458  42 ARG I  804  ILE I  807  1                                   4
HELIX  459  43 PRO I  815  ALA I  823  1                                   9
HELIX  460  44 ASP I  829  TYR I  836  1                                   8
HELIX  461  45 ARG I  860  THR I  871  1                                  12
HELIX  462  46 LEU I  880  GLU I  885  1                                   6
HELIX  463  47 ARG I  888  ASP I  898  1                                  11
HELIX  464  48 LEU I  914  THR I  916  1                                   3
HELIX  465  49 TYR I  919  MET I  930  1                                  12
HELIX  466  50 ARG I  933  THR I  935  1                                   3
HELIX  467  51 VAL I  941  PHE I  958  1                                  18
HELIX  468  52 TYR I  970  ASP I  974  1                                   5
HELIX  469  53 PRO I  976  ALA I  986  1                                  11
HELIX  470  54 PRO I  988  ARG I  991  1                                   4
HELIX  471  55 ALA I  997  MET I 1006  1                                  10
HELIX  472  56 PHE I 1025  LYS I 1030  1                                   6
HELIX  473  57 TRP I 1035  GLU I 1038  1                                   4
HELIX  474  58 LEU I 1040  ALA I 1042  1                                   3
HELIX  475  59 VAL I 1048  ARG I 1050  1                                   3
HELIX  476  60 ILE I 1070  TYR I 1090  1                                  21
HELIX  477  61 GLU I 1094  LYS I 1096  1                                   3
HELIX  478  62 GLU I 1135  ALA I 1143  1                                   9
HELIX  479  63 TRP I 1149  LEU I 1155  1                                   7
HELIX  480  64 PRO I 1169  VAL I 1173  1                                   5
HELIX  481  65 SER I 1190  LYS I 1192  1                                   3
HELIX  482  66 ARG I 1258  TRP I 1270  1                                  13
HELIX  483  67 ALA I 1294  VAL I 1304  1                                  11
HELIX  484  68 GLU I 1309  PHE I 1311  1                                   3
HELIX  485  69 MET I 1323  ILE I 1338  1                                  16
HELIX  486  70 LEU I 1347  LYS I 1349  1                                   3
HELIX  487  71 PHE I 1419  ASN I 1421  1                                   3
HELIX  488  72 SER I 1438  SER I 1446  1                                   9
HELIX  489  73 PRO I 1515  ASN I 1523  1                                   9
HELIX  490  74 GLU I 1551  SER I 1557  1                                   7
HELIX  491  75 PRO I 1562  HIS I 1564  1                                   3
HELIX  492  76 ARG I 1567  ALA I 1573  1                                   7
HELIX  493  77 GLY I 1582  ALA I 1597  1                                  16
HELIX  494  78 SER I 1602  ARG I 1604  1                                   3
HELIX  495  79 MET I 1678  THR I 1683  1                                   6
HELIX  496  80 LYS I 1685  TYR I 1702  1                                  18
HELIX  497  81 ILE I 1706  ILE I 1711  1                                   6
HELIX  498  82 GLU I 1724  SER I 1734  1                                  11
HELIX  499  83 LEU I 1770  SER I 1772  1                                   3
HELIX  500  84 THR I 1774  LYS I 1795  1                                  22
HELIX  501  85 GLY I 1810  ALA I 1819  1                                  10
HELIX  502  86 ILE I 1824  VAL I 1840  1                                  17
HELIX  503  87 PRO I 1859  VAL I 1862  1                                   4
HELIX  504  88 GLN I 1868  THR I 1882  1                                  15
HELIX  505  89 LEU I 1904  GLN I 1920  1                                  17
HELIX  506  90 ILE I 1924  SER I 1930  1                                   7
HELIX  507  91 LEU I 1933  ALA I 1952  1                                  20
HELIX  508  92 THR I 1979  LEU I 1981  1                                   3
HELIX  509  93 VAL I 1985  ASN I 1995  1                                  11
HELIX  510  94 LYS I 1998  ASN I 2000  1                                   3
HELIX  511  95 VAL I 2003  LEU I 2006  1                                   4
HELIX  512  96 LYS I 2023  THR I 2033  1                                  11
HELIX  513  97 GLU I 2036  ASP I 2043  1                                   8
SHEET    1  M1 5 VAL A  26  ARG A  27  0
SHEET    2  M1 5 VAL G1886  VAL G1893  1  O  ASN G1890   N  VAL A  26
SHEET    3  M1 5 GLN G1897  ASP G1903 -1  N  GLN G1897   O  VAL G1893
SHEET    4  M1 5 TYR G1852  ILE G1857 -1  N  TYR G1852   O  ASP G1903
SHEET    5  M1 5 CYS G1966  PRO G1968 -1  N  CYS G1966   O  ILE G1857
SHEET    1  M2 5 GLU A  77  CYS A  80  0
SHEET    2  M2 5 ARG A  43  ILE A  47  1  O  ARG A  43   N  GLU A  77
SHEET    3  M2 5 THR G1662  PHE G1666  1  O  THR G1662   N  ARG A  43
SHEET    4  M2 5 THR G1803  GLY G1806  1  O  THR G1803   N  THR G1663
SHEET    5  M2 5 TYR G2010  ILE G2011  1  O  TYR G2010   N  PHE G1804
SHEET    1  M310 ARG A 400  PHE A 402  0
SHEET    2  M310 THR A 731  PRO A 736 -1  N  LEU A 732   O  PHE A 402
SHEET    3  M310 LYS A 702  THR A 707  1  O  LYS A 702   N  THR A 731
SHEET    4  M310 TYR A 677  THR A 681  1  O  TYR A 677   N  LYS A 702
SHEET    5  M310 ALA A 767  PRO A 770  1  O  ALA A 767   N  VAL A 678
SHEET    6  M310 ALA A 820  MET A 826  1  O  GLN A 821   N  ALA A 767
SHEET    7  M310 LEU A 862  ILE A 869  1  O  LEU A 862   N  ALA A 820
SHEET    8  M310 VAL A 922  LEU A 926  1  O  VAL A 922   N  CYS A 865
SHEET    9  M310 HIS A 639  LYS A 643 -1  N  HIS A 639   O  ASP A 925
SHEET   10  M310 TRP A 649  TYR A 651 -1  N  TRP A 649   O  LYS A 643
SHEET    1  M4 2 THR A 497  ILE A 503  0
SHEET    2  M4 2 ILE A 509  PRO A 515 -1  N  ILE A 509   O  ILE A 503
SHEET    1  M5 2 THR A 872  ARG A 873  0
SHEET    2  M5 2 PHE A 896  SER A 897  1  O  PHE A 896   N  THR A 872
SHEET    1  M6 2 GLU A 981  ILE A 982  0
SHEET    2  M6 2 THR G 963  LEU G 964 -1  N  THR G 963   O  ILE A 982
SHEET    1  M710 VAL A1624  LEU A1625  0
SHEET    2  M710 VAL A1572  VAL A1575  1  O  VAL A1572   N  VAL A1624
SHEET    3  M710 LEU A1536  SER A1540  1  O  VAL A1538   N  ILE A1573
SHEET    4  M710 ALA A1638  GLY A1645  1  O  ALA A1638   N  LEU A1536
SHEET    5  M710 LYS A1649  VAL A1656 -1  N  LYS A1649   O  GLY A1645
SHEET    6  M710 GLY A1402  ALA A1410 -1  N  ILE A1403   O  VAL A1656
SHEET    7  M710 ILE A1019  VAL A1027 -1  N  ILE A1019   O  VAL A1404
SHEET    8  M710 GLY A1381  GLN A1389 -1  N  ALA A1382   O  VAL A1027
SHEET    9  M710 ILE A1326  ASP A1333 -1  N  ILE A1326   O  MET A1388
SHEET   10  M710 VAL A1243  SER A1249  1  O  VAL A1243   N  ILE A1326
SHEET    1  M8 2 ILE A1060  LEU A1067  0
SHEET    2  M8 2 ARG A1070  ASP A1077 -1  N  ARG A1070   O  LEU A1067
SHEET    1  M9 2 ILE A1103  LEU A1105  0
SHEET    2  M9 2 VAL A1185  GLY A1187 -1  N  VAL A1185   O  LEU A1105
SHEET    1 M10 2 LYS A1119  ILE A1126  0
SHEET    2 M10 2 THR A1172  LEU A1179 -1  N  THR A1172   O  ILE A1126
SHEET    1 M11 3 LEU A1131  ALA A1136  0
SHEET    2 M11 3 TYR A1163  LEU A1167 -1  N  TYR A1163   O  ALA A1136
SHEET    3 M11 3 VAL A1152  GLU A1156 -1  N  VAL A1152   O  LEU A1167
SHEET    1 M12 2 ILE A1604  ILE A1605  0
SHEET    2 M12 2 LEU A1631  LYS A1632 -1  N  LEU A1631   O  ILE A1605
SHEET    1 M13 2 SER A1723  LYS A1724  0
SHEET    2 M13 2 LEU A1731  THR A1732 -1  N  LEU A1731   O  LYS A1724
SHEET    1 M14 2 ARG G   7  HIS G  13  0
SHEET    2 M14 2 LEU G  16  VAL G  22 -1  N  LEU G  16   O  HIS G  13
SHEET    1 M15 4 LEU G 267  GLY G 272  0
SHEET    2 M15 4 LEU G 156  PHE G 160  1  O  LEU G 156   N  LEU G 267
SHEET    3 M15 4 HIS G 500  ASP G 503  1  O  HIS G 500   N  LEU G 156
SHEET    4 M15 4 ARG G 526  VAL G 529  1  O  ARG G 526   N  HIS G 500
SHEET    1 M16 5 SER G 417  PHE G 420  0
SHEET    2 M16 5 MET G 338  SER G 342 -1  N  LEU G 339   O  PHE G 420
SHEET    3 M16 5 ASN G 376  SER G 380 -1  N  ASN G 376   O  SER G 342
SHEET    4 M16 5 GLU G 367  VAL G 371 -1  N  GLU G 367   O  SER G 380
SHEET    5 M16 5 VAL G 488  LYS G 489  1  O  VAL G 488   N  LEU G 370
SHEET    1 M17 2 ILE G 577  GLU G 580  0
SHEET    2 M17 2 LYS G 568  LYS G 571 -1  N  LYS G 568   O  GLU G 580
SHEET    1 M18 9 THR G 616  ALA G 620  0
SHEET    2 M18 9 LEU G 592  VAL G 594  1  O  LEU G 593   N  THR G 616
SHEET    3 M18 9 PHE G 799  LEU G 800  1  O  PHE G 799   N  LEU G 592
SHEET    4 M18 9 ILE G 763  GLY G 768  1  O  PHE G 767   N  PHE G 799
SHEET    5 M18 9 ILE G 728  TRP G 732  1  O  ILE G 728   N  ILE G 763
SHEET    6 M18 9 TYR G 702  LEU G 705  1  O  LEU G 703   N  ILE G 728
SHEET    7 M18 9 ILE G 676  GLY G 682  1  O  PHE G 678   N  TYR G 702
SHEET    8 M18 9 PHE G 647  ILE G 652  1  O  PHE G 647   N  ILE G 676
SHEET    9 M18 9 THR G 616  ALA G 620  1  O  ILE G 617   N  GLY G 648
SHEET    1 M19 3 GLY G 739  HIS G 740  0
SHEET    2 M19 3 PRO G 853  ILE G 857 -1  N  ILE G 854   O  HIS G 740
SHEET    3 M19 3 ILE G 843  ARG G 847 -1  N  ILE G 843   O  ILE G 857
SHEET    1 M20 2 THR G 906  VAL G 907  0
SHEET    2 M20 2 GLN G 910  ALA G 911 -1  N  GLN G 910   O  VAL G 907
SHEET    1 M21 2 PHE G 931  ILE G 932  0
SHEET    2 M21 2 SER G 937  TRP G 938 -1  N  SER G 937   O  ILE G 932
SHEET    1 M22 9 ALA G1125  LYS G1128  0
SHEET    2 M22 9 VAL G1181  SER G1185 -1  N  VAL G1181   O  LYS G1128
SHEET    3 M22 9 VAL G1194  VAL G1201 -1  N  VAL G1194   O  SER G1185
SHEET    4 M22 9 GLU G1204  LEU G1214 -1  N  GLU G1204   O  VAL G1201
SHEET    5 M22 9 ILE G1218  GLU G1225 -1  N  ILE G1218   O  LEU G1214
SHEET    6 M22 9 VAL G1234  PHE G1242 -1  N  VAL G1234   O  GLU G1225
SHEET    7 M22 9 ILE G1251  GLU G1253 -1  N  ILE G1251   O  PHE G1242
SHEET    8 M22 9 PHE G1158  GLN G1161  1  O  THR G1160   N  SER G1252
SHEET    9 M22 9 MET G1164  SER G1167 -1  N  MET G1164   O  GLN G1161
SHEET    1 M2310 ILE G1285  GLU G1291  0
SHEET    2 M2310 VAL G1371  ASN G1383 -1  N  VAL G1371   O  GLU G1291
SHEET    3 M2310 GLY G1387  ARG G1398 -1  N  LYS G1388   O  ASN G1383
SHEET    4 M2310 LYS G1401  ARG G1413 -1  N  LYS G1401   O  ARG G1398
SHEET    5 M2310 LEU G1350  MET G1359 -1  N  LEU G1350   O  TYR G1412
SHEET    6 M2310 VAL G1605  PHE G1612 -1  N  GLY G1607   O  LYS G1358
SHEET    7 M2310 VAL G1649  ILE G1657 -1  N  LEU G1651   O  PHE G1612
SHEET    8 M2310 ARG G1635  ARG G1643 -1  N  LYS G1636   O  ILE G1657
SHEET    9 M2310 ALA G1621  ILE G1632 -1  N  LYS G1623   O  ARG G1643
SHEET   10 M2310 LYS G1530  TYR G1545 -1  N  LYS G1530   O  ILE G1632
SHEET    1 M24 6 PHE G1450  LEU G1452  0
SHEET    2 M24 6 THR G1498  GLY G1509 -1  N  GLY G1502   O  LEU G1452
SHEET    3 M24 6 PHE G1480  GLU G1492 -1  N  SER G1482   O  GLY G1509
SHEET    4 M24 6 THR G1463  PHE G1474 -1  N  LEU G1464   O  VAL G1491
SHEET    5 M24 6 PHE G1423  HIS G1434 -1  N  GLN G1424   O  VAL G1472
SHEET    6 M24 6 SER G1525  THR G1526 -1  N  SER G1525   O  GLN G1432
SHEET    1 M2514 PHE G1450  LEU G1452  0
SHEET    2 M2514 THR G1498  GLY G1509 -1  N  GLY G1502   O  LEU G1452
SHEET    3 M2514 PHE G1480  GLU G1492 -1  N  SER G1482   O  GLY G1509
SHEET    4 M2514 THR G1463  PHE G1474 -1  N  LEU G1464   O  VAL G1491
SHEET    5 M2514 PHE G1423  HIS G1434 -1  N  GLN G1424   O  VAL G1472
SHEET    6 M2514 VAL G1371  ASN G1383 -1  N  VAL G1371   O  GLN G1424
SHEET    7 M2514 GLY G1387  ARG G1398 -1  N  LYS G1388   O  ASN G1383
SHEET    8 M2514 LYS G1401  ARG G1413 -1  N  LYS G1401   O  ARG G1398
SHEET    9 M2514 LEU G1350  MET G1359 -1  N  LEU G1350   O  TYR G1412
SHEET   10 M2514 VAL G1605  PHE G1612 -1  N  GLY G1607   O  LYS G1358
SHEET   11 M2514 VAL G1649  ILE G1657 -1  N  LEU G1651   O  PHE G1612
SHEET   12 M2514 ARG G1635  ARG G1643 -1  N  LYS G1636   O  ILE G1657
SHEET   13 M2514 ALA G1621  ILE G1632 -1  N  LYS G1623   O  ARG G1643
SHEET   14 M2514 LYS G1530  TYR G1545 -1  N  LYS G1530   O  ILE G1632
SHEET    1 M26 2 ASN G1716  HIS G1720  0
SHEET    2 M26 2 SER G1761  ARG G1765 -1  N  SER G1761   O  HIS G1720
SHEET    1 M27 2 ILE G1737  VAL G1742  0
SHEET    2 M27 2 LYS G1745  LYS G1750 -1  N  LYS G1745   O  VAL G1742
SHEET    1  N1 5 VAL B  26  ARG B  27  0
SHEET    2  N1 5 VAL H1886  VAL H1893  1  O  ASN H1890   N  VAL B  26
SHEET    3  N1 5 GLN H1897  ASP H1903 -1  N  GLN H1897   O  VAL H1893
SHEET    4  N1 5 TYR H1852  ILE H1857 -1  N  TYR H1852   O  ASP H1903
SHEET    5  N1 5 CYS H1966  PRO H1968 -1  N  CYS H1966   O  ILE H1857
SHEET    1  N2 5 GLU B  77  CYS B  80  0
SHEET    2  N2 5 ARG B  43  ILE B  47  1  O  ARG B  43   N  GLU B  77
SHEET    3  N2 5 THR H1662  PHE H1666  1  O  THR H1662   N  ARG B  43
SHEET    4  N2 5 THR H1803  GLY H1806  1  O  THR H1803   N  THR H1663
SHEET    5  N2 5 TYR H2010  ILE H2011  1  O  TYR H2010   N  PHE H1804
SHEET    1  N310 ARG B 400  PHE B 402  0
SHEET    2  N310 THR B 731  PRO B 736 -1  N  LEU B 732   O  PHE B 402
SHEET    3  N310 LYS B 702  THR B 707  1  O  LYS B 702   N  THR B 731
SHEET    4  N310 TYR B 677  THR B 681  1  O  TYR B 677   N  LYS B 702
SHEET    5  N310 ALA B 767  PRO B 770  1  O  ALA B 767   N  VAL B 678
SHEET    6  N310 ALA B 820  MET B 826  1  O  GLN B 821   N  ALA B 767
SHEET    7  N310 LEU B 862  ILE B 869  1  O  LEU B 862   N  ALA B 820
SHEET    8  N310 VAL B 922  LEU B 926  1  O  VAL B 922   N  CYS B 865
SHEET    9  N310 HIS B 639  LYS B 643 -1  N  HIS B 639   O  ASP B 925
SHEET   10  N310 TRP B 649  TYR B 651 -1  N  TRP B 649   O  LYS B 643
SHEET    1  N4 2 THR B 497  ILE B 503  0
SHEET    2  N4 2 ILE B 509  PRO B 515 -1  N  ILE B 509   O  ILE B 503
SHEET    1  N5 2 THR B 872  ARG B 873  0
SHEET    2  N5 2 PHE B 896  SER B 897  1  O  PHE B 896   N  THR B 872
SHEET    1  N6 2 GLU B 981  ILE B 982  0
SHEET    2  N6 2 THR H 963  LEU H 964 -1  N  THR H 963   O  ILE B 982
SHEET    1  N710 VAL B1624  LEU B1625  0
SHEET    2  N710 VAL B1572  VAL B1575  1  O  VAL B1572   N  VAL B1624
SHEET    3  N710 LEU B1536  SER B1540  1  O  VAL B1538   N  ILE B1573
SHEET    4  N710 ALA B1638  GLY B1645  1  O  ALA B1638   N  LEU B1536
SHEET    5  N710 LYS B1649  VAL B1656 -1  N  LYS B1649   O  GLY B1645
SHEET    6  N710 GLY B1402  ALA B1410 -1  N  ILE B1403   O  VAL B1656
SHEET    7  N710 ILE B1019  VAL B1027 -1  N  ILE B1019   O  VAL B1404
SHEET    8  N710 GLY B1381  GLN B1389 -1  N  ALA B1382   O  VAL B1027
SHEET    9  N710 ILE B1326  ASP B1333 -1  N  ILE B1326   O  MET B1388
SHEET   10  N710 VAL B1243  SER B1249  1  O  VAL B1243   N  ILE B1326
SHEET    1  N8 2 ILE B1060  LEU B1067  0
SHEET    2  N8 2 ARG B1070  ASP B1077 -1  N  ARG B1070   O  LEU B1067
SHEET    1  N9 2 ILE B1103  LEU B1105  0
SHEET    2  N9 2 VAL B1185  GLY B1187 -1  N  VAL B1185   O  LEU B1105
SHEET    1 N10 2 LYS B1119  ILE B1126  0
SHEET    2 N10 2 THR B1172  LEU B1179 -1  N  THR B1172   O  ILE B1126
SHEET    1 N11 3 LEU B1131  ALA B1136  0
SHEET    2 N11 3 TYR B1163  LEU B1167 -1  N  TYR B1163   O  ALA B1136
SHEET    3 N11 3 VAL B1152  GLU B1156 -1  N  VAL B1152   O  LEU B1167
SHEET    1 N12 2 ILE B1604  ILE B1605  0
SHEET    2 N12 2 LEU B1631  LYS B1632 -1  N  LEU B1631   O  ILE B1605
SHEET    1 N13 2 SER B1723  LYS B1724  0
SHEET    2 N13 2 LEU B1731  THR B1732 -1  N  LEU B1731   O  LYS B1724
SHEET    1 N14 2 ARG H   7  HIS H  13  0
SHEET    2 N14 2 LEU H  16  VAL H  22 -1  N  LEU H  16   O  HIS H  13
SHEET    1 N15 4 LEU H 267  GLY H 272  0
SHEET    2 N15 4 LEU H 156  PHE H 160  1  O  LEU H 156   N  LEU H 267
SHEET    3 N15 4 HIS H 500  ASP H 503  1  O  HIS H 500   N  LEU H 156
SHEET    4 N15 4 ARG H 526  VAL H 529  1  O  ARG H 526   N  HIS H 500
SHEET    1 N16 5 SER H 417  PHE H 420  0
SHEET    2 N16 5 MET H 338  SER H 342 -1  N  LEU H 339   O  PHE H 420
SHEET    3 N16 5 ASN H 376  SER H 380 -1  N  ASN H 376   O  SER H 342
SHEET    4 N16 5 GLU H 367  VAL H 371 -1  N  GLU H 367   O  SER H 380
SHEET    5 N16 5 VAL H 488  LYS H 489  1  O  VAL H 488   N  LEU H 370
SHEET    1 N17 2 ILE H 577  GLU H 580  0
SHEET    2 N17 2 LYS H 568  LYS H 571 -1  N  LYS H 568   O  GLU H 580
SHEET    1 N18 9 THR H 616  ALA H 620  0
SHEET    2 N18 9 LEU H 592  VAL H 594  1  O  LEU H 593   N  THR H 616
SHEET    3 N18 9 PHE H 799  LEU H 800  1  O  PHE H 799   N  LEU H 592
SHEET    4 N18 9 ILE H 763  GLY H 768  1  O  PHE H 767   N  PHE H 799
SHEET    5 N18 9 ILE H 728  TRP H 732  1  O  ILE H 728   N  ILE H 763
SHEET    6 N18 9 TYR H 702  LEU H 705  1  O  LEU H 703   N  ILE H 728
SHEET    7 N18 9 ILE H 676  GLY H 682  1  O  PHE H 678   N  TYR H 702
SHEET    8 N18 9 PHE H 647  ILE H 652  1  O  PHE H 647   N  ILE H 676
SHEET    9 N18 9 THR H 616  ALA H 620  1  O  ILE H 617   N  GLY H 648
SHEET    1 N19 3 GLY H 739  HIS H 740  0
SHEET    2 N19 3 PRO H 853  ILE H 857 -1  N  ILE H 854   O  HIS H 740
SHEET    3 N19 3 ILE H 843  ARG H 847 -1  N  ILE H 843   O  ILE H 857
SHEET    1 N20 2 THR H 906  VAL H 907  0
SHEET    2 N20 2 GLN H 910  ALA H 911 -1  N  GLN H 910   O  VAL H 907
SHEET    1 N21 2 PHE H 931  ILE H 932  0
SHEET    2 N21 2 SER H 937  TRP H 938 -1  N  SER H 937   O  ILE H 932
SHEET    1 N22 9 ALA H1125  LYS H1128  0
SHEET    2 N22 9 VAL H1181  SER H1185 -1  N  VAL H1181   O  LYS H1128
SHEET    3 N22 9 VAL H1194  VAL H1201 -1  N  VAL H1194   O  SER H1185
SHEET    4 N22 9 GLU H1204  LEU H1214 -1  N  GLU H1204   O  VAL H1201
SHEET    5 N22 9 ILE H1218  GLU H1225 -1  N  ILE H1218   O  LEU H1214
SHEET    6 N22 9 VAL H1234  PHE H1242 -1  N  VAL H1234   O  GLU H1225
SHEET    7 N22 9 ILE H1251  GLU H1253 -1  N  ILE H1251   O  PHE H1242
SHEET    8 N22 9 PHE H1158  GLN H1161  1  O  THR H1160   N  SER H1252
SHEET    9 N22 9 MET H1164  SER H1167 -1  N  MET H1164   O  GLN H1161
SHEET    1 N2310 ILE H1285  GLU H1291  0
SHEET    2 N2310 VAL H1371  ASN H1383 -1  N  VAL H1371   O  GLU H1291
SHEET    3 N2310 GLY H1387  ARG H1398 -1  N  LYS H1388   O  ASN H1383
SHEET    4 N2310 LYS H1401  ARG H1413 -1  N  LYS H1401   O  ARG H1398
SHEET    5 N2310 LEU H1350  MET H1359 -1  N  LEU H1350   O  TYR H1412
SHEET    6 N2310 VAL H1605  PHE H1612 -1  N  GLY H1607   O  LYS H1358
SHEET    7 N2310 VAL H1649  ILE H1657 -1  N  LEU H1651   O  PHE H1612
SHEET    8 N2310 ARG H1635  ARG H1643 -1  N  LYS H1636   O  ILE H1657
SHEET    9 N2310 ALA H1621  ILE H1632 -1  N  LYS H1623   O  ARG H1643
SHEET   10 N2310 LYS H1530  TYR H1545 -1  N  LYS H1530   O  ILE H1632
SHEET    1 N24 6 PHE H1450  LEU H1452  0
SHEET    2 N24 6 THR H1498  GLY H1509 -1  N  GLY H1502   O  LEU H1452
SHEET    3 N24 6 PHE H1480  GLU H1492 -1  N  SER H1482   O  GLY H1509
SHEET    4 N24 6 THR H1463  PHE H1474 -1  N  LEU H1464   O  VAL H1491
SHEET    5 N24 6 PHE H1423  HIS H1434 -1  N  GLN H1424   O  VAL H1472
SHEET    6 N24 6 SER H1525  THR H1526 -1  N  SER H1525   O  GLN H1432
SHEET    1 N2514 PHE H1450  LEU H1452  0
SHEET    2 N2514 THR H1498  GLY H1509 -1  N  GLY H1502   O  LEU H1452
SHEET    3 N2514 PHE H1480  GLU H1492 -1  N  SER H1482   O  GLY H1509
SHEET    4 N2514 THR H1463  PHE H1474 -1  N  LEU H1464   O  VAL H1491
SHEET    5 N2514 PHE H1423  HIS H1434 -1  N  GLN H1424   O  VAL H1472
SHEET    6 N2514 VAL H1371  ASN H1383 -1  N  VAL H1371   O  GLN H1424
SHEET    7 N2514 GLY H1387  ARG H1398 -1  N  LYS H1388   O  ASN H1383
SHEET    8 N2514 LYS H1401  ARG H1413 -1  N  LYS H1401   O  ARG H1398
SHEET    9 N2514 LEU H1350  MET H1359 -1  N  LEU H1350   O  TYR H1412
SHEET   10 N2514 VAL H1605  PHE H1612 -1  N  GLY H1607   O  LYS H1358
SHEET   11 N2514 VAL H1649  ILE H1657 -1  N  LEU H1651   O  PHE H1612
SHEET   12 N2514 ARG H1635  ARG H1643 -1  N  LYS H1636   O  ILE H1657
SHEET   13 N2514 ALA H1621  ILE H1632 -1  N  LYS H1623   O  ARG H1643
SHEET   14 N2514 LYS H1530  TYR H1545 -1  N  LYS H1530   O  ILE H1632
SHEET    1 N26 2 ASN H1716  HIS H1720  0
SHEET    2 N26 2 SER H1761  ARG H1765 -1  N  SER H1761   O  HIS H1720
SHEET    1 N27 2 ILE H1737  VAL H1742  0
SHEET    2 N27 2 LYS H1745  LYS H1750 -1  N  LYS H1745   O  VAL H1742
SHEET    1  O1 5 VAL C  26  ARG C  27  0
SHEET    2  O1 5 VAL I1886  VAL I1893  1  O  ASN I1890   N  VAL C  26
SHEET    3  O1 5 GLN I1897  ASP I1903 -1  N  GLN I1897   O  VAL I1893
SHEET    4  O1 5 TYR I1852  ILE I1857 -1  N  TYR I1852   O  ASP I1903
SHEET    5  O1 5 CYS I1966  PRO I1968 -1  N  CYS I1966   O  ILE I1857
SHEET    1  O2 5 GLU C  77  CYS C  80  0
SHEET    2  O2 5 ARG C  43  ILE C  47  1  O  ARG C  43   N  GLU C  77
SHEET    3  O2 5 THR I1662  PHE I1666  1  O  THR I1662   N  ARG C  43
SHEET    4  O2 5 THR I1803  GLY I1806  1  O  THR I1803   N  THR I1663
SHEET    5  O2 5 TYR I2010  ILE I2011  1  O  TYR I2010   N  PHE I1804
SHEET    1  O310 ARG C 400  PHE C 402  0
SHEET    2  O310 THR C 731  PRO C 736 -1  N  LEU C 732   O  PHE C 402
SHEET    3  O310 LYS C 702  THR C 707  1  O  LYS C 702   N  THR C 731
SHEET    4  O310 TYR C 677  THR C 681  1  O  TYR C 677   N  LYS C 702
SHEET    5  O310 ALA C 767  PRO C 770  1  O  ALA C 767   N  VAL C 678
SHEET    6  O310 ALA C 820  MET C 826  1  O  GLN C 821   N  ALA C 767
SHEET    7  O310 LEU C 862  ILE C 869  1  O  LEU C 862   N  ALA C 820
SHEET    8  O310 VAL C 922  LEU C 926  1  O  VAL C 922   N  CYS C 865
SHEET    9  O310 HIS C 639  LYS C 643 -1  N  HIS C 639   O  ASP C 925
SHEET   10  O310 TRP C 649  TYR C 651 -1  N  TRP C 649   O  LYS C 643
SHEET    1  O4 2 THR C 497  ILE C 503  0
SHEET    2  O4 2 ILE C 509  PRO C 515 -1  N  ILE C 509   O  ILE C 503
SHEET    1  O5 2 THR C 872  ARG C 873  0
SHEET    2  O5 2 PHE C 896  SER C 897  1  O  PHE C 896   N  THR C 872
SHEET    1  O6 2 GLU C 981  ILE C 982  0
SHEET    2  O6 2 THR I 963  LEU I 964 -1  N  THR I 963   O  ILE C 982
SHEET    1  O710 VAL C1624  LEU C1625  0
SHEET    2  O710 VAL C1572  VAL C1575  1  O  VAL C1572   N  VAL C1624
SHEET    3  O710 LEU C1536  SER C1540  1  O  VAL C1538   N  ILE C1573
SHEET    4  O710 ALA C1638  GLY C1645  1  O  ALA C1638   N  LEU C1536
SHEET    5  O710 LYS C1649  VAL C1656 -1  N  LYS C1649   O  GLY C1645
SHEET    6  O710 GLY C1402  ALA C1410 -1  N  ILE C1403   O  VAL C1656
SHEET    7  O710 ILE C1019  VAL C1027 -1  N  ILE C1019   O  VAL C1404
SHEET    8  O710 GLY C1381  GLN C1389 -1  N  ALA C1382   O  VAL C1027
SHEET    9  O710 ILE C1326  ASP C1333 -1  N  ILE C1326   O  MET C1388
SHEET   10  O710 VAL C1243  SER C1249  1  O  VAL C1243   N  ILE C1326
SHEET    1  O8 2 ILE C1060  LEU C1067  0
SHEET    2  O8 2 ARG C1070  ASP C1077 -1  N  ARG C1070   O  LEU C1067
SHEET    1  O9 2 ILE C1103  LEU C1105  0
SHEET    2  O9 2 VAL C1185  GLY C1187 -1  N  VAL C1185   O  LEU C1105
SHEET    1 O10 2 LYS C1119  ILE C1126  0
SHEET    2 O10 2 THR C1172  LEU C1179 -1  N  THR C1172   O  ILE C1126
SHEET    1 O11 3 LEU C1131  ALA C1136  0
SHEET    2 O11 3 TYR C1163  LEU C1167 -1  N  TYR C1163   O  ALA C1136
SHEET    3 O11 3 VAL C1152  GLU C1156 -1  N  VAL C1152   O  LEU C1167
SHEET    1 O12 2 ILE C1604  ILE C1605  0
SHEET    2 O12 2 LEU C1631  LYS C1632 -1  N  LEU C1631   O  ILE C1605
SHEET    1 O13 2 SER C1723  LYS C1724  0
SHEET    2 O13 2 LEU C1731  THR C1732 -1  N  LEU C1731   O  LYS C1724
SHEET    1 O14 2 ARG I   7  HIS I  13  0
SHEET    2 O14 2 LEU I  16  VAL I  22 -1  N  LEU I  16   O  HIS I  13
SHEET    1 O15 4 LEU I 267  GLY I 272  0
SHEET    2 O15 4 LEU I 156  PHE I 160  1  O  LEU I 156   N  LEU I 267
SHEET    3 O15 4 HIS I 500  ASP I 503  1  O  HIS I 500   N  LEU I 156
SHEET    4 O15 4 ARG I 526  VAL I 529  1  O  ARG I 526   N  HIS I 500
SHEET    1 O16 5 SER I 417  PHE I 420  0
SHEET    2 O16 5 MET I 338  SER I 342 -1  N  LEU I 339   O  PHE I 420
SHEET    3 O16 5 ASN I 376  SER I 380 -1  N  ASN I 376   O  SER I 342
SHEET    4 O16 5 GLU I 367  VAL I 371 -1  N  GLU I 367   O  SER I 380
SHEET    5 O16 5 VAL I 488  LYS I 489  1  O  VAL I 488   N  LEU I 370
SHEET    1 O17 2 ILE I 577  GLU I 580  0
SHEET    2 O17 2 LYS I 568  LYS I 571 -1  N  LYS I 568   O  GLU I 580
SHEET    1 O18 9 THR I 616  ALA I 620  0
SHEET    2 O18 9 LEU I 592  VAL I 594  1  O  LEU I 593   N  THR I 616
SHEET    3 O18 9 PHE I 799  LEU I 800  1  O  PHE I 799   N  LEU I 592
SHEET    4 O18 9 ILE I 763  GLY I 768  1  O  PHE I 767   N  PHE I 799
SHEET    5 O18 9 ILE I 728  TRP I 732  1  O  ILE I 728   N  ILE I 763
SHEET    6 O18 9 TYR I 702  LEU I 705  1  O  LEU I 703   N  ILE I 728
SHEET    7 O18 9 ILE I 676  GLY I 682  1  O  PHE I 678   N  TYR I 702
SHEET    8 O18 9 PHE I 647  ILE I 652  1  O  PHE I 647   N  ILE I 676
SHEET    9 O18 9 THR I 616  ALA I 620  0  O  ILE I 617   N  GLY I 648
SHEET    1 O19 3 GLY I 739  HIS I 740  0
SHEET    2 O19 3 PRO I 853  ILE I 857 -1  N  ILE I 854   O  HIS I 740
SHEET    3 O19 3 ILE I 843  ARG I 847 -1  N  ILE I 843   O  ILE I 857
SHEET    1 O20 2 THR I 906  VAL I 907  0
SHEET    2 O20 2 GLN I 910  ALA I 911 -1  N  GLN I 910   O  VAL I 907
SHEET    1 O21 2 PHE I 931  ILE I 932  0
SHEET    2 O21 2 SER I 937  TRP I 938 -1  N  SER I 937   O  ILE I 932
SHEET    1 O22 9 ALA I1125  LYS I1128  0
SHEET    2 O22 9 VAL I1181  SER I1185 -1  N  VAL I1181   O  LYS I1128
SHEET    3 O22 9 VAL I1194  VAL I1201 -1  N  VAL I1194   O  SER I1185
SHEET    4 O22 9 GLU I1204  LEU I1214 -1  N  GLU I1204   O  VAL I1201
SHEET    5 O22 9 ILE I1218  GLU I1225 -1  N  ILE I1218   O  LEU I1214
SHEET    6 O22 9 VAL I1234  PHE I1242 -1  N  VAL I1234   O  GLU I1225
SHEET    7 O22 9 ILE I1251  GLU I1253 -1  N  ILE I1251   O  PHE I1242
SHEET    8 O22 9 PHE I1158  GLN I1161  1  O  THR I1160   N  SER I1252
SHEET    9 O22 9 MET I1164  SER I1167 -1  N  MET I1164   O  GLN I1161
SHEET    1 O2310 ILE I1285  GLU I1291  0
SHEET    2 O2310 VAL I1371  ASN I1383 -1  N  VAL I1371   O  GLU I1291
SHEET    3 O2310 GLY I1387  ARG I1398 -1  N  LYS I1388   O  ASN I1383
SHEET    4 O2310 LYS I1401  ARG I1413 -1  N  LYS I1401   O  ARG I1398
SHEET    5 O2310 LEU I1350  MET I1359 -1  N  LEU I1350   O  TYR I1412
SHEET    6 O2310 VAL I1605  PHE I1612 -1  N  GLY I1607   O  LYS I1358
SHEET    7 O2310 VAL I1649  ILE I1657 -1  N  LEU I1651   O  PHE I1612
SHEET    8 O2310 ARG I1635  ARG I1643 -1  N  LYS I1636   O  ILE I1657
SHEET    9 O2310 ALA I1621  ILE I1632 -1  N  LYS I1623   O  ARG I1643
SHEET   10 O2310 LYS I1530  TYR I1545 -1  N  LYS I1530   O  ILE I1632
SHEET    1 O24 6 PHE I1450  LEU I1452  0
SHEET    2 O24 6 THR I1498  GLY I1509 -1  N  GLY I1502   O  LEU I1452
SHEET    3 O24 6 PHE I1480  GLU I1492 -1  N  SER I1482   O  GLY I1509
SHEET    4 O24 6 THR I1463  PHE I1474 -1  N  LEU I1464   O  VAL I1491
SHEET    5 O24 6 PHE I1423  HIS I1434 -1  N  GLN I1424   O  VAL I1472
SHEET    6 O24 6 SER I1525  THR I1526 -1  N  SER I1525   O  GLN I1432
SHEET    1 O2514 PHE I1450  LEU I1452  0
SHEET    2 O2514 THR I1498  GLY I1509 -1  N  GLY I1502   O  LEU I1452
SHEET    3 O2514 PHE I1480  GLU I1492 -1  N  SER I1482   O  GLY I1509
SHEET    4 O2514 THR I1463  PHE I1474 -1  N  LEU I1464   O  VAL I1491
SHEET    5 O2514 PHE I1423  HIS I1434 -1  N  GLN I1424   O  VAL I1472
SHEET    6 O2514 VAL I1371  ASN I1383 -1  N  VAL I1371   O  GLN I1424
SHEET    7 O2514 GLY I1387  ARG I1398 -1  N  LYS I1388   O  ASN I1383
SHEET    8 O2514 LYS I1401  ARG I1413 -1  N  LYS I1401   O  ARG I1398
SHEET    9 O2514 LEU I1350  MET I1359 -1  N  LEU I1350   O  TYR I1412
SHEET   10 O2514 VAL I1605  PHE I1612 -1  N  GLY I1607   O  LYS I1358
SHEET   11 O2514 VAL I1649  ILE I1657 -1  N  LEU I1651   O  PHE I1612
SHEET   12 O2514 ARG I1635  ARG I1643 -1  N  LYS I1636   O  ILE I1657
SHEET   13 O2514 ALA I1621  ILE I1632 -1  N  LYS I1623   O  ARG I1643
SHEET   14 O2514 LYS I1530  TYR I1545 -1  N  LYS I1530   O  ILE I1632
SHEET    1 O26 2 ASN I1716  HIS I1720  0
SHEET    2 O26 2 SER I1761  ARG I1765 -1  N  SER I1761   O  HIS I1720
SHEET    1 O27 2 ILE I1737  VAL I1742  0
SHEET    2 O27 2 LYS I1745  LYS I1750 -1  N  LYS I1745   O  VAL I1742
LINK         C   LYS A 179                 N   GVL A 180     1555   1555  1.33
LINK         C   GVL A 180                 N   THR A 181     1555   1555  1.33
LINK         C   LYS B 179                 N   GVL B 180     1555   1555  1.33
LINK         C   GVL B 180                 N   THR B 181     1555   1555  1.33
LINK         C   LYS C 179                 N   GVL C 180     1555   1555  1.33
LINK         C   GVL C 180                 N   THR C 181     1555   1555  1.33
SITE     1 AC1 18 PRO G 595  GLY G 596  MET G 597  THR G 598
SITE     2 AC1 18 PRO G 599  ASN G 650  ILE G 652  GLY G 682
SITE     3 AC1 18 LYS G 706  THR G 733  GLY G 737  GLY G 738
SITE     4 AC1 18 SER G 769  GLY G 770  GLY G 802  SER G 803
SITE     5 AC1 18 LEU G1054  ALA G1059
SITE     1 AC2 18 PRO H 595  GLY H 596  MET H 597  THR H 598
SITE     2 AC2 18 PRO H 599  ASN H 650  ILE H 652  GLY H 682
SITE     3 AC2 18 LYS H 706  THR H 733  GLY H 737  GLY H 738
SITE     4 AC2 18 SER H 769  GLY H 770  GLY H 802  SER H 803
SITE     5 AC2 18 LEU H1054  ALA H1059
SITE     1 AC3 18 PRO I 595  GLY I 596  MET I 597  THR I 598
SITE     2 AC3 18 PRO I 599  ASN I 650  ILE I 652  GLY I 682
SITE     3 AC3 18 LYS I 706  THR I 733  GLY I 737  GLY I 738
SITE     4 AC3 18 SER I 769  GLY I 770  GLY I 802  SER I 803
SITE     5 AC3 18 LEU I1054  ALA I1059
CRYST1  230.600  230.600  784.300  90.00  90.00  90.00 P 41 21 2    24
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.004337  0.000000  0.000000        0.00000
SCALE2      0.000000  0.004337  0.000000        0.00000
SCALE3      0.000000  0.000000  0.001275        0.00000
      
PROCHECK
Go to PROCHECK summary
 References