PDBsum entry 2tgp

Complex (proteinase/inhibitor)

PDB id: 2tgp

Contents

Protein chains

223 a.a. *

58 a.a. *

Ligands

SO4 ×2

Metals

_CA

Waters ×138

* Residue conservation analysis

PDB id:

2tgp

Name:

Complex (proteinase/inhibitor)

Title:

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors

Structure:

Trypsinogen. Chain: z. Engineered: yes. Trypsin inhibitor. Chain: i. Engineered: yes

Source:

Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Organism_taxid: 9913

Biol. unit:

Octamer (from PQS)

Resolution:

1.90Å R-factor: 0.200

Authors:

R.Huber,W.Bode,J.Deisenhofer,P.Schwager

Key ref:

M.Marquart et al. (1983). The geometry of the reactive site and of the peptide groups in trypsin, Trypsinogen and its complexes with inhibitors. Acta crystallogr ,Sect b, 39, 480.

Date:

27-Sep-82 Release date: 18-Jan-83

Supersedes:

1tgp

Protein chain

P00760  (TRY1_BOVIN) -  Serine protease 1 from Bos taurus

Seq: 246 a.a.

Struc: 223 a.a.

Protein chain

P00974  (BPT1_BOVIN) -  Pancreatic trypsin inhibitor from Bos taurus

Seq: 100 a.a.

Struc: 58 a.a.

Enzyme reactions

• Enzyme class: Chain Z: E.C.3.4.21.4 - trypsin.
• Reaction: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.