UniProt functional annotation for P29355



	UniProt functional annotation for P29355

UniProt code: P29355.

Organism: Caenorhabditis elegans.

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.

Function: Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23 (PubMed:1372395, PubMed:16547100). Involved in sex myoblast migration (PubMed:1372395, PubMed:9073451). Negatively regulates fluid homeostasis probably downstream of egl-15 (PubMed:1372395, PubMed:11689700). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15 (PubMed:16495308). Involved in cytoskeleton dynamics and is recruited by mig-13 to the leading edge of Q neuroblasts and their descendants to signal downstream to activate the wsp-1 pathway and direct migration along the anteroposterior body axis during larval development (PubMed:27780040). Involved in let-23-mediated regulation of fertility independently of let-60/Ras (PubMed:16547100). Negatively regulates daf-2-mediated repression of dauer formation (PubMed:16547100). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870). Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord (PubMed:15990870). May play a role in oocyte development upstream of let-60/Ras and the MAP kinase pathway (PubMed:12169634). {ECO:0000269|PubMed:11689700, ECO:0000269|PubMed:12169634, ECO:0000269|PubMed:1372395, ECO:0000269|PubMed:15990870, ECO:0000269|PubMed:16495308, ECO:0000269|PubMed:16547100, ECO:0000269|PubMed:27780040, ECO:0000269|PubMed:9073451}.

Subunit: Interacts (probably via SH3 domain 2) with soc-1 (via C- terminus) (PubMed:16547100). Interacts with mig-2 (active GTP-bound form) and wsp-1 (PubMed:27780040). Interacts with mig-13; the interaction is direct (PubMed:27780040). {ECO:0000269|PubMed:16547100, ECO:0000269|PubMed:27780040}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:27780040}. Note=Targeted to the leading edge of Q neuroblasts by mig-13. {ECO:0000269|PubMed:27780040}.

Tissue specificity: Expressed in body wall muscles, pharynx, intestine and hypodermis. {ECO:0000269|PubMed:16495308}.

Disruption phenotype: RNAi-mediated knockdown or RNAi-mediated knockdown in body wall muscles causes ectopic membrane extensions from body wall muscles. {ECO:0000269|PubMed:16495308}.

Similarity: Belongs to the GRB2/sem-5/DRK family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Caenorhabditis elegans.
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.



Function:		Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23 (PubMed:1372395, PubMed:16547100). Involved in sex myoblast migration (PubMed:1372395, PubMed:9073451). Negatively regulates fluid homeostasis probably downstream of egl-15 (PubMed:1372395, PubMed:11689700). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15 (PubMed:16495308). Involved in cytoskeleton dynamics and is recruited by mig-13 to the leading edge of Q neuroblasts and their descendants to signal downstream to activate the wsp-1 pathway and direct migration along the anteroposterior body axis during larval development (PubMed:27780040). Involved in let-23-mediated regulation of fertility independently of let-60/Ras (PubMed:16547100). Negatively regulates daf-2-mediated repression of dauer formation (PubMed:16547100). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870). Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord (PubMed:15990870). May play a role in oocyte development upstream of let-60/Ras and the MAP kinase pathway (PubMed:12169634). {ECO:0000269\|PubMed:11689700, ECO:0000269\|PubMed:12169634, ECO:0000269\|PubMed:1372395, ECO:0000269\|PubMed:15990870, ECO:0000269\|PubMed:16495308, ECO:0000269\|PubMed:16547100, ECO:0000269\|PubMed:27780040, ECO:0000269\|PubMed:9073451}.


Subunit:		Interacts (probably via SH3 domain 2) with soc-1 (via C- terminus) (PubMed:16547100). Interacts with mig-2 (active GTP-bound form) and wsp-1 (PubMed:27780040). Interacts with mig-13; the interaction is direct (PubMed:27780040). {ECO:0000269\|PubMed:16547100, ECO:0000269\|PubMed:27780040}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:27780040}. Note=Targeted to the leading edge of Q neuroblasts by mig-13. {ECO:0000269\|PubMed:27780040}.
Tissue specificity:		Expressed in body wall muscles, pharynx, intestine and hypodermis. {ECO:0000269\|PubMed:16495308}.
Disruption phenotype:		RNAi-mediated knockdown or RNAi-mediated knockdown in body wall muscles causes ectopic membrane extensions from body wall muscles. {ECO:0000269\|PubMed:16495308}.
Similarity:		Belongs to the GRB2/sem-5/DRK family. {ECO:0000305}.