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UniProt functional annotation for Q7TS63 | ||
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| UniProt code: Q7TS63. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated. {ECO:0000269|PubMed:18329245}. |
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| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:18329245}. Cytoplasm, cytosol {ECO:0000269|PubMed:18329245}. |
| Tissue specificity: | |
Detected in spleen and thymus but not in liver, muscle, heart, kidney, brain, bone marrow or pancreas. Expressed in CD19+, CD4+ and CD8+ lymphocytes but not in CD11b+ lymphocytes or peritoneal macrophages (at protein level). {ECO:0000269|PubMed:18329245}. |
| Developmental stage: | |
Up-regulated during the transition from CD4-/CD8- to CD4+/CD8+ thymocytes. {ECO:0000269|PubMed:18329245}. |
Annotations taken from UniProtKB at the EBI.