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UniProt functional annotation for P15514 | ||
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| UniProt code: P15514. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. |
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| Subunit: | |
The immature precursor interacts with CNIH. {ECO:0000269|PubMed:17607000}. |
| Subcellular location: | |
Membrane; Single-pass membrane protein. |
| Induction: | |
By phorbol 12-myristate 13-acetate (PMA). |
| Miscellaneous: | |
AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity. |
| Similarity: | |
Belongs to the amphiregulin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.