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UniProt functional annotation for Q8CGF7 | ||
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| UniProt code: Q8CGF7. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner (By similarity). {ECO:0000250}. |
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| Subunit: | |
Binds RNA polymerase II, HD and SF1 (By similarity). Binds formin. Interacts (via the second WW domain) with TREX1 (via proline- rich region). {ECO:0000250, ECO:0000269|PubMed:15485897, ECO:0000269|PubMed:17355961, ECO:0000269|PubMed:8605874}. |
| Subcellular location: | |
Nucleus {ECO:0000250}. |
| Domain: | |
The FF domains preferentially binds peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5) and mediate interaction with HTATSF1 and probably bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II. {ECO:0000269|PubMed:15485897}. |
| Domain: | |
The WW domains bind Pro-rich domains. {ECO:0000269|PubMed:15485897}. |
| Sequence caution: | |
Sequence=AAH39185.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.