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PDBsum entry 2reb
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DNA binding protein
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PDB id
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2reb
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References listed in PDB file
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Key reference
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Title
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The structure of the e. Coli reca protein monomer and polymer.
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Authors
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R.M.Story,
I.T.Weber,
T.A.Steitz.
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Ref.
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Nature, 1992,
355,
318-325.
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PubMed id
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Abstract
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The crystal structure of the recA protein from Escherichia coli at 2.3-A
resolution reveals a major domain that binds ADP and probably single- and
double-stranded DNA. Two smaller subdomains at the N and C termini protrude from
the protein and respectively stabilize a 6(1) helical polymer of protein
subunits and interpolymer bundles. This polymer structure closely resembles that
of recA/DNA filaments determined by electron microscopy. Mutations in recA
protein that enhance coprotease, DNA-binding and/or strand-exchange activity can
be explained if the interpolymer interactions in the crystal reflect a
regulatory mechanism in vivo.
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Secondary reference #1
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Title
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Structure of the reca protein-Adp complex.
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Authors
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R.M.Story,
T.A.Steitz.
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Ref.
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Nature, 1992,
355,
374-376.
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PubMed id
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Secondary reference #2
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Title
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The structure of the e. Coli recA protein monomer and polymer: erratum
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Authors
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R.M.Story,
I.T.Weber,
T.A.Steitz.
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Ref.
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nature, 1992,
355,
567.
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