UniProt functional annotation for P0A7L0



	UniProt functional annotation for P0A7L0

UniProt code: P0A7L0.

Organism: Escherichia coli (strain K12).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.

Function: One of the primary rRNA binding proteins, it binds very close to the 3'-end of the 23S rRNA. Forms part of the L1 stalk. It is often not seen in high-resolution crystal structures, but can be seen in cryo_EM and 3D reconstruction models. These indicate that the distal end of the stalk moves by approximately 20 angstroms (PubMed:12859903, PubMed:16272117). This stalk movement is thought to be coupled to movement of deacylated tRNA into and out of the E site, and thus to participate in tRNA translocation (PubMed:12859903, PubMed:16272117). Contacts the P and E site tRNAs. {ECO:0000269|PubMed:12859903, ECO:0000269|PubMed:16272117}.

Function: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

Subunit: Part of the 50S ribosomal subunit. Cross-links to the P and E site tRNAs.

Mass spectrometry: Mass=24598.9; Method=MALDI; Evidence={ECO:0000269|PubMed:10094780};

Similarity: Belongs to the universal ribosomal protein uL1 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Escherichia coli (strain K12).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.



Function:		One of the primary rRNA binding proteins, it binds very close to the 3'-end of the 23S rRNA. Forms part of the L1 stalk. It is often not seen in high-resolution crystal structures, but can be seen in cryo_EM and 3D reconstruction models. These indicate that the distal end of the stalk moves by approximately 20 angstroms (PubMed:12859903, PubMed:16272117). This stalk movement is thought to be coupled to movement of deacylated tRNA into and out of the E site, and thus to participate in tRNA translocation (PubMed:12859903, PubMed:16272117). Contacts the P and E site tRNAs. {ECO:0000269\|PubMed:12859903, ECO:0000269\|PubMed:16272117}.



Function:		Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.


Subunit:		Part of the 50S ribosomal subunit. Cross-links to the P and E site tRNAs.
Mass spectrometry:		Mass=24598.9; Method=MALDI; Evidence={ECO:0000269\|PubMed:10094780};
Similarity:		Belongs to the universal ribosomal protein uL1 family. {ECO:0000305}.