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UniProt functional annotation for Q8VHN2 | ||
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| UniProt code: Q8VHN2. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. |
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| Subunit: | |
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane. {ECO:0000250}. |
| Tissue specificity: | |
Expressed in the hippocampus, the corpus callosum, in the facial and trigeminal nuclei of the brainstem and the ventral horn of the spinal cord. {ECO:0000269|PubMed:11735224, ECO:0000269|PubMed:11823786}. |
| Similarity: | |
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.