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UniProt functional annotation for P71408 | ||
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| UniProt code: P71408. |
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| Organism: | |
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori). |
| Taxonomy: | |
Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter. |
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| Function: | |
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. {ECO:0000255|HAMAP- Rule:MF_01458}. |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000255|HAMAP-Rule:MF_01458}; Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01458}; |
| Subunit: | |
Homohexamer. {ECO:0000255|HAMAP-Rule:MF_01458}. |
| Subcellular location: | |
Cell inner membrane {ECO:0000305|PubMed:8892813}; Multi-pass membrane protein {ECO:0000305|PubMed:8892813}; Cytoplasmic side {ECO:0000305|PubMed:8892813}. |
| Disruption phenotype: | |
A homozygous disruption strain was not identified, suggesting this gene may be essential. {ECO:0000269|PubMed:8892813}. |
| Similarity: | |
In the central section; belongs to the AAA ATPase family. {ECO:0000255|HAMAP-Rule:MF_01458}. |
| Similarity: | |
In the C-terminal section; belongs to the peptidase M41 family. {ECO:0000255|HAMAP-Rule:MF_01458}. |
Annotations taken from UniProtKB at the EBI.