UniProt functional annotation for Q02206



	UniProt functional annotation for Q02206

UniProt code: Q02206.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. {ECO:0000269|PubMed:10025404, ECO:0000269|PubMed:10329629, ECO:0000269|PubMed:12072455, ECO:0000269|PubMed:12183366, ECO:0000269|PubMed:12697820, ECO:0000269|PubMed:8980231}.

Subunit: Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin.

Subcellular location: Nucleus {ECO:0000269|PubMed:12697820, ECO:0000269|PubMed:14562095}. Note=Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1.

Miscellaneous: Present with 8570 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. {ECO:0000269\|PubMed:10025404, ECO:0000269\|PubMed:10329629, ECO:0000269\|PubMed:12072455, ECO:0000269\|PubMed:12183366, ECO:0000269\|PubMed:12697820, ECO:0000269\|PubMed:8980231}.


Subunit:		Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:12697820, ECO:0000269\|PubMed:14562095}. Note=Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1.
Miscellaneous:		Present with 8570 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.