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PDBsum entry 2qzh
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Immune system PDB id
2qzh

 

 

 

 

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Contents
Protein chain
129 a.a. *
* Residue conservation analysis
PDB id:
2qzh
Name: Immune system
Title: Scr2/3 of daf from the nmr structure 1nwv fitted into a cryoem reconstruction of cvb3-rd complexed with daf
Structure: Complement decay-accelerating factor. Chain: a. Fragment: scr2/3 domains. Synonym: cd55 antigen. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Authors: S.Hafenstein,V.D.Bowman,P.R.Chipman,C.M.Bator Kelly,F.Lin,M.E.Medof, M.G.Rossmann
Key ref: S.Hafenstein et al. (2007). Interaction of decay-accelerating factor with coxsackievirus B3. J Virol, 81, 12927-12935. PubMed id: 17804498
Date:
16-Aug-07     Release date:   30-Oct-07    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P08174  (DAF_HUMAN) -  Complement decay-accelerating factor from Homo sapiens
Seq:
Struc: 		381 a.a.
129 a.a.*
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.?
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
J Virol 81:12927-12935 (2007)
PubMed id: 17804498  
 
 
Interaction of decay-accelerating factor with coxsackievirus B3.
S.Hafenstein, V.D.Bowman, P.R.Chipman, C.M.Bator Kelly, F.Lin, M.E.Medof, M.G.Rossmann.
 
  ABSTRACT  
 
Many entero-, parecho-, and rhinoviruses use immunoglobulin (Ig)-like receptors that bind into the viral canyon and are required to initiate viral uncoating during infection. However, some of these viruses use an alternative or additional receptor that binds outside the canyon. Both the coxsackievirus-adenovirus receptor (CAR), an Ig-like molecule that binds into the viral canyon, and decay-accelerating factor (DAF) have been identified as cellular receptors for coxsackievirus B3 (CVB3). A cryoelectron microscopy reconstruction of a variant of CVB3 complexed with DAF shows full occupancy of the DAF receptor in each of 60 binding sites. The DAF molecule bridges the canyon, blocking the CAR binding site and causing the two receptors to compete with one another. The binding site of DAF on CVB3 differs from the binding site of DAF on the surface of echoviruses, suggesting independent evolutionary processes.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
20631132 M.Gullberg, C.Tolf, N.Jonsson, M.N.Mulders, C.Savolainen-Kopra, T.Hovi, M.Van Ranst, P.Lemey, S.Hafenstein, and A.M.Lindberg (2010).
Characterization of a putative ancestor of coxsackievirus B5.
  J Virol, 84, 9695-9708.  
19555476 J.W.Gow, S.Hagan, P.Herzyk, C.Cannon, P.O.Behan, and A.Chaudhuri (2009).
A gene signature for post-infectious chronic fatigue syndrome.
  BMC Med Genomics, 2, 38.  
19321620 S.Hafenstein, V.D.Bowman, T.Sun, C.D.Nelson, L.M.Palermo, P.R.Chipman, A.J.Battisti, C.R.Parrish, and M.G.Rossmann (2009).
Structural comparison of different antibodies interacting with parvovirus capsids.
  J Virol, 83, 5556-5566.
PDB codes: 3iy0 3iy1 3iy2 3iy3 3iy4 3iy5 3iy6 3iy7
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.

 

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