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PDBsum entry 2qzf
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Immune system
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PDB id
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2qzf
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References listed in PDB file
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Key reference
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Title
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Interaction of decay-Accelerating factor with coxsackievirus b3.
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Authors
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S.Hafenstein,
V.D.Bowman,
P.R.Chipman,
C.M.Bator kelly,
F.Lin,
M.E.Medof,
M.G.Rossmann.
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Ref.
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J Virol, 2007,
81,
12927-12935.
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PubMed id
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Abstract
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Many entero-, parecho-, and rhinoviruses use immunoglobulin (Ig)-like receptors
that bind into the viral canyon and are required to initiate viral uncoating
during infection. However, some of these viruses use an alternative or
additional receptor that binds outside the canyon. Both the
coxsackievirus-adenovirus receptor (CAR), an Ig-like molecule that binds into
the viral canyon, and decay-accelerating factor (DAF) have been identified as
cellular receptors for coxsackievirus B3 (CVB3). A cryoelectron microscopy
reconstruction of a variant of CVB3 complexed with DAF shows full occupancy of
the DAF receptor in each of 60 binding sites. The DAF molecule bridges the
canyon, blocking the CAR binding site and causing the two receptors to compete
with one another. The binding site of DAF on CVB3 differs from the binding site
of DAF on the surface of echoviruses, suggesting independent evolutionary
processes.
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