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UniProt functional annotation for Q27974 | ||
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| UniProt code: Q27974. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (PubMed:15502813). Plays a role in clathrin-mediated endocytosis in neurons (By similarity). {ECO:0000250|UniProtKB:Q80TZ3, ECO:0000269|PubMed:15502813}. |
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| Catalytic activity: | |
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; |
| Subunit: | |
Interacts with HSPA8/HSC70. Interacts with clathrin heavy chains. {ECO:0000269|PubMed:12741832}. |
| Tissue specificity: | |
Brain. {ECO:0000269|PubMed:7705342}. |
| Ptm: | |
The N-terminus is blocked. {ECO:0000269|PubMed:7705342}. |
| Ptm: | |
Target for coat-associated casein kinase II in vitro. {ECO:0000305|PubMed:7705342}. |
Annotations taken from UniProtKB at the EBI.